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Biomedical subjects

J Schmidt

Publications and source records attributed to J Schmidt.

At least 397 records · Page 22Linked to original sources
PubMed1995

[Therapeutic complications from insulin antibodies--two case reports].

Immunological complications of insulin therapy are extremely rare, since highly purified insulins, especially human semi- or biosynthetic insulin preparations became available for treatment of diabetes mellitus. Insulin antibodies of the immunoglobulin G or immunoglobulin E class can develop in 10-60%, however, in low titers in patients treated exclusively with human insulin. In rare cases these antibodies assume clinical significance, if the antigenic potential of the insulin used is high enough and if genetic predisposition exists. Two case reports presented here confirm this concept.

Aged↗
PubMed1995

Recurrent cytogenetic aberrations in human ovarian carcinomas.

Successful cytogenetic analysis was performed on short-term cultures of 62 malignant ovarian tumors from 42 patients. Twenty-three tumors from 18 patients revealed clonal chromosome abnormalities. Five cases showed nonclonal chromosome changes. In the remaining 19 cases, a normal female karyotype was found. Numerical or single structural changes were found in only 11 carcinomas from nine patients. Trisomy 12 and 7 were each the sole abnormality in two cases a piece. One tumor showed a trisomy 6 as the only karyotypic change. Four tumors revealed simple translocations and deletions affecting the chromosomes X, 1, 2, 6, and 7. Twelve of the cytogenetically abnormal tumor samples showed complex karyotypes with both numerical and structural aberrations leading to hyperdiploid, near-triploid, and near-tetraploid stemlines. The recurrent numerical imbalances were losses of the chromosomes 1 (N = 5), X (N = 3), and 17 (N = 3), and gains of the chromosomes 12 (N = 5) and 20 (N = 3). Regarding structural rearrangements, the chromosome bands 11p13-14 and 19p13 were the most frequently affected regions. 11p13-14 was rearranged in four tumors. In two cases, a deletion 11p13-14 was found. Two tumors revealed a nonreciprocal translocation involving 11p13-14 and leading to the loss of distal 11p material. The most consistent finding was a 19p+ marker chromosome, which was present in five different ovarian carcinomas. Our results are in accordance with a recent cytogenetic report describing a 19p+ marker and loss of 11p material as consistent cytogenetic aberrations in human ovarian carcinomas.

Adenocarcinoma↗
PubMed1995

[Multiple gastric wall abscesses--a rare differential endosonographic diagnosis of submucous stomach tumors].

We report a rare case of a 52 year old patient with multiple gastric wall abscesses. In 1987 a selective proximal vagotomy was performed. Because of non-specific gastric symptoms in 1993 an endoscopy and an endoscopic ultrasound was performed at another hospital which resulted in the likely diagnosis of multiple leiomyomas. Three months later a control endosonography showed three well demarcated submucosal tumors, partly echo-genic, but with an inhomogeneous echo-pattern. A laparotomy and histological examination of the submucosal gastric tumors revealed multiple gastric abscesses with granulomas after selective proximal vagotomy. Difficulties in the differential diagnosis of submucosal gastric tumors arising from this case are demonstrated and discussed.

Abscess↗
PubMed1995

Bone matrix deposition of T1, a homologue of interleukin 1 receptors.

The mouse T1 glycoprotein is a secreted molecule of the immunoglobulin superfamily with significant homology to interleukin 1 receptors. It is expressed during bone development, and the extracellular diffusible gene product is found associated with newly formed bone but not cartilage matrix. During osteogenic differentiation of mandibular condyles of newborn mice in vitro, T1 gene expression is induced shortly after cultivation and is observed throughout the differentiation process. The temporal expression pattern of the gene is an mandibular condyles indicates that T1 expression is an early marker of osteogenic differentiation. This view is substantiated by the analysis of T1 gene regulation in continuous osteogenic cell lines. Both in differentiating osteoblast-like KM-1K cells derived from mandibular condyles and in MC3T3 cells, T1 gene activity is preferentially associated with early differentiation stages. In mandibular condyles, the secreted extracellular T1 protein is deposited into newly formed osteoid but not into cartilage matrix. This novel bone matrix protein may locally modulate the availability of its ligand.

Animals↗
PubMed1995

[2 sets of monozygotic twins concordant for anorexia nervosa].

The case reports at hand describe the discordant and the common characteristics of two pairs of monozygotic twins, concordant for anorexia nervosa. The resulting test scores of psychometric questionnaires including the Eating Attitudes Test (EAT) and the Eating Disorders Inventory (EDI) are descriptively presented and compared with each other. Finally the psychodynamic and the psychogenetic implications considering biogenetic findings are discussed.

Adult↗
PubMed1995

[Stochastic models of neuronal activity].

Techniques for modeling of a stochastic activity of neurons are briefly reviewed. Our model is proposed, some experimental results with input Gaussian stochastic processes are discussed, and the concept of e-curves is introduced.

Models, Neurological↗
PubMed1995

[A model of stochastic activity of the neuron].

Techniques for modeling of a stochastic activity of neurons are briefly reviewed. Our model is proposed, some experimental results with input Gaussian stochastic processes are discussed, and the concept of e-curves is introduced.

Action Potentials↗
PubMed1995

[Traction vitreoretinal opticopathy in proliferative diabetic vitreoretinopathy].

UNLABELLED: In patients with proliferative diabetic vitreoretinopathy the authors noticed tractive vitreoretinal distortion of the optic disk to the nasal side. As a result of this distortion a reduction in visual acuity, pallor of the optic disk, and changes in the visual evoked potentials were registered. The disease in called "tractive vitreoretinal opticopathy." METHOD: We examined 15 diabetics with vitreoretinal traction and temporal pallor of the optic disk, as well as a reduction in visual acuity. Six patients were observed retrospectively and 9 patients prospectively before and after vitrectomy. Pre- and postoperative examinations included visual acuity, visual field, fluorescence angiography, and the conduction of visual evoked potentials (VEP). RESULTS: Within a postoperative follow-up of 2-8 months (mean 6.5 months) a return of optical vitality combined with an increase in visual acuity could be seen in 14 of 15 patients. In addition, some of the patients showed an improvement in the amplitudes and a reduction in the latency of the VEP. CONCLUSIONS: The authors assume that the axoplasmatic flow in the optic nerve fibers is reduced according to vitreoretinal traction. Furthermore, the traction may cause elongation of the capillaries, resulting in reduced perfusion of the optic disk. For these reasons early vitrectomy in patients with tractive vitreoretinal opticopathy is recommended.

Adult↗
PubMed1995

[Selected immunopathological aspects of the internal ear].

Basing on the actual world literature authors present some complicated immunopathologic processes taking place in inner ear. Immunological mechanism loss of inner ear hasn't been taken into consideration by clinicists too frequent so far. At the same time diagnostic difficulties were pointed in this information in case of suspicion of inner ear disease basing on immunological process.

Ear, Inner↗
PubMed1995

[Treatment of internal ear diseases of immunological etiology].

Basing on the actual world literature authors present opinions concerning methods of healing damages of internal ear caused by immunological processes. The following methods of healing internal ear damages are mentioned above: using of steroids in high doses for a long time, steroids and cytostatic drugs or cytostatic drugs itself (in case of bad toleration) or steroids parallelly with plasmaphoresis (as supporting method) or plasmaphoresis itself.

Anti-Inflammatory Agents↗
PubMed1994

The effect of different corticosteroids and cyclosporin A on interleukin-4 and interleukin-5 release from murine TH2-type T cells.

By secretion of interleukin-4 and interleukin-5, TH2-type T cells are thought to play an important role in the pathogenesis of asthma. Corticosteroids are currently the most effective therapy available for asthma, but recently it has been demonstrated that cyclosporin A improves lung function in patients with severe corticosteroid-dependent asthma. In order to examine the effects of corticosteroids and cyclosporin A on anti-CD3-induced production of interleukin-4 and interleukin-5 we used the murine TH2-type cell clone D10.G4.1. Interleukin-4/interleukin-5 release was inhibited by all drugs tested with the following IC50 values (nmol/l) for interleukin-4 and interleukin-5, respectively: budesonide (0.32/0.22), beclomethasone (0.65/0.33), dexamethasone (4.70/3.52), 6 alpha-methyl-prednisolone (24.04/17.02), hydrocortisone (34.27/22.55), and cyclosporin A (72.59/242.21). In conclusion, corticosteroids exert strong inhibitory effects on cytokine production by TH2-cells, which may explain, at least partly, its clinical efficacy in asthma. Cyclosporin A also showed a concentration-dependent inhibition; however, in relation to corticosteroids the inhibitory activity of cyclosporin A was found to be weaker.

Adrenal Cortex Hormones↗