Biomedical subjects

J Schaanning

Publications and source records attributed to J Schaanning.

33 records · Page 2Linked to original sources

PubMed1976

Effect of atenolol on ventilatory and cardiac function in asthma.

The effects on ventilatory and cardiac function of atenolol, a new cardioselective beta-adrenoceptor blocking agent, were compared with those of practolol in a double-blind trial in 12 patients with asthma. Both drugs impaired ventilatory function--atenolol insignificantly and practolol significantly. Atenolol was if anything more cardioselective than practolol. Neither drug interfered significantly with the bronchodilator response to inhaled isoprenaline. Atenolol is suitable for use in patients for whom practolol would formerly have been chosen because of its cardioselectivity.

Adrenergic beta-Antagonists↗

PubMed1976

Beta1-blocker (practolol) and exercise in patients with chronic obstructive lung disease.

Ventilatory and circulatory data from 20 patients suffering from chronic obstructive lung disease have been obtained before, during and after exercise at 600 kpm/min for 5 min on a bicycle ergometer. The patients had been given intravenously practolol, 15 mg, or saline alternatively, using a double-blind cross-over technique. A slight postexercise reduction of FEV1 (8%) was noted after practolol medication as compared to placebo, with an accompanying decrease in PaCO2; PaO2 did not differ substantially. No wheezing or inappropriate dyspnea attributable to the medication was noted in any of the patients. The well known beta1-blocking effects on the circulation were confirmed, with maintained Q and reduced HR, together with a lowered systemic BP during and after exercise. There was a significant positive relationship between the postexercise reduction of FEV1 and the concomitant fall in HR. It is concluded that practolol in doses with near maximal circulatory effects had a slight, but clinically insignificant effect on the ventilatory parameters.

Adult↗

PubMed1976

Influence of posture on pulmonary gas exchange and heart rate in chronic obstructive lung disease.

Sixteen subjects with chronic obstructive lung disease were studied in supine and sitting position. VT, VE, VD and VD/VT were definitely higher in the sitting position (p less than 0.001). PaCO2 was slightly lower in the sitting position, whereas Pa¿O2 was the same in both positions. P(A-a)O2 was essentially the same in both positions, but the estimated QS/QT was definitely lower in the sitting position. In patients with low FEV1.0 the heart rate showed a tendency towards higher values in the sitting position.

Adult↗

PubMed1976

Ventilatory and heart rate adjustments during submaximal and maximal exercise in patients with chronic obstructive lung disease.

Thirty-four patients with chronic obstructive lung disease were exercised stepwise up to maximal work load. V02 at maximal work load showed a slightly significant correlation to FEV1, while a closer association with VC as well as Ve and Vt was noted. In most patients Vt during maximal exercise was around 50% of VC, while no such limit was present when Vt was related to FEV1. These patterns were independent of the clinical type of obstructive lung disease. At 300 kpm/min (50 W) Vt/VC% as well as heart rate was negatively correlated to V02 max, but not to FEV1. No significant relationship was seen between V02 or Ve at this exercise level and V02 max, as well as FEV1. The ventilatory pattern during exercise seemed to reflect the patients' ventilatory strain more adequately than pre-exercise FEV1. The negative relationship between heart rate during moderate exercise and V02 max might further reflect this strain.

Bronchitis↗

PubMed1975