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Biomedical subjects

J Schönebeck

Publications and source records attributed to J Schönebeck.

At least 19 recordsLinked to original sources
PubMed1983

Blood concentration of lignocaine after application of 2% lignocaine gel in the urethra.

In 35 patients undergoing topical anaesthesia with lignocaine (lidocaine) gel (2% Xylocaine gel) the concentration of lignocaine base was measured in repeated venous blood samples. Twenty patients (group I) were given 20 ml of 2% lignocaine gel (400 mg lignocaine) and 5 patients (group II) received 40 ml (800 mg lignocaine) endourethrally. These 2 groups of patients underwent either dilation of the urethra or urethrocystoscopy. Ten patients (group III) undergoing transurethral resection of the prostate or a bladder tumour, were given 20 ml of gel (400 mg lignocaine) plus spinal anaesthesia with 2 ml of 5% lignocaine (100 mg lignocaine) with 7.5% glucose (Xylocaine "heavy"). The mean peak blood concentrations of lignocaine in these 3 groups were 0.06, 0.15 and 0.36 micrograms/ml respectively. Patients undergoing urethral dilatation had significantly higher blood concentrations than cystoscopy patients. The blood concentrations in group III were not higher than the expected value when spinal anaesthesia and lignocaine gel were given simultaneously. There was no statistically significant difference in the blood concentration between patients undergoing different types of transurethral resection (prostate and cancer of the bladder). Lignocaine applied endourethrally gives an extremely low blood concentration which is far below the level which can cause general toxic symptoms.

Administration, Topical↗
PubMed1980

Antibiotics to patients with urinary infections in connection with transurethral prostatectomy.

79 male patients with bladder neck obstruction and urinary tract infection were randomly divided into two groups prior to transurethral prostatectomy. One group (37 patients) was treated preoperatively and for 10 days postoperatively with cephazolin-cephalexin, and the other group (42 patients) was treated with methenamine hippurate in the same way. In the first group, 2 patients developed chills postoperatively without untoward effect on their general condition. In the second group, 7 patients developed postoperative sepsis with systemic symptoms while on therapy with methenamine hippurate: therapy was then changed to cephazolin--cephalexin and the patients were cured. Urinary cultures 4--9 weeks postoperatively did not show bacterial growth in 21/37 treated with cephalosporins and in 11/42 treated with methenamine hippurate. This difference is statistically significant (P = 0.0082).

Aged↗
PubMed1978

Pathogenicity in mice of strains of Candida albicans with different in vitro sensitivity to 5-fluorocytosine.

The pathogenicity in mice of 7 strains of Candida albicans with different in vitro susceptibility to 5-fluorocytosine (5-FC) was investigated. Resistant strains were not less virulent than susceptible strains. This is contradictory to findings reported for candida strains resistant to polyene antibiotics, which were less pathogenic than susceptible strains. The implications of these findings are discussed.

Animals↗
PubMed1975

Acute hypertension and perirenal haematoma--a new aspect of Page's syndrome.

Chronic hypertension induced by perirenal constrictive processes is known from experimental studies as well as from clinical experience. In this report we present 2 cases of acute hypertension induced by massive perirenal haematoma, in 1 case as a complication following pyeloplasty, in the other as a complication following percutaneous renal biopsy. Since the shock may be masked by the hypertension (and operation thereby postponed) it is essential to be aware of this syndrome.

Acute Disease↗
PubMed1975

Incidence, morbidity and complications of renal and ureteral calculi in a well defined geographical area.

In a well defined geographical area with only one hospital, the incidence of upper urinary tract stone was found to be 180 per 100 000 inhabitants, a figure not substantially higher than that reported more than 30 years ago. The male/female ratio was 3.6:1. The mean frequency of recurrence was 40% and the mean frequency of infection 12%. Hyperparathyroidism was found in 1.4% of all cases. Thirty-five per cent of the patients required hospital treatment and 19% needed operation. Renal pelvic stone was more common in the female (22%) than in the male (8.5%) patients. Spontaneous passage of stone occurred in 87.5% of the men and in 81.5% of the women. No seasonal variation in the onset of acute pain was demonstrable.

Adolescent↗