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Biomedical subjects

J Schädelin

Publications and source records attributed to J Schädelin.

At least 19 recordsLinked to original sources
PubMed1990

[Cat-scratch disease].

Cat scratch disease is a self-limited but chronic lymphadenitis which has acquired new interest by the description of a responsible pathogen, an intracellularly located gram-negative rod. Due to its low pathogenicity for laboratory animals, the definite proof for causality is still lacking. Severe systemic courses, mainly in immune suppressed patients, can however be identified more positively by detection of this pathogen. A routine diagnostic test is likely to be developed in the near future and therapeutic guidelines for the minority of severe, progressive forms may be drawn up.

Cat-Scratch Disease↗
PubMed1988

Preventive therapy of herpes labialis associated with trigeminal surgery.

Acyclovir was shown to limit herpes simplex reactivation in a controlled trial to prevent herpes labialis after surgical intervention for trigeminal neuralgia. Of 14 patients receiving acyclovir, unambiguous herpes labialis developed in only one, compared with 12 of 16 in the placebo group.

Acyclovir↗
PubMed1985

[Prevalence of antibodies against HTLV-III in various regions in Switzerland].

Acquired immune deficiency syndrome (AIDS) has been etiologically linked with the human T-cell lymphotropic virus HTLV-III. In a study on the prevalence of antibodies to this virus in Switzerland, sera from 941 individuals were collected in 5 major urban areas (Basel, Berne, Geneva, Lausanne and Zurich) in 1983 and 1984. All sera were tested by ELISA and the majority also by Western blot. We found an antibody prevalence of 100% among 22 cases of AIDS, of 94% among 48 cases of AIDS-related complex (ARC), and of 57% among 14 homosexual contacts of AIDS patients. Among 55 sera collected from i.v. drug addicts in 1984, 53% were positive, whereas the rate had been 36% among 103 sera collected in 1983. The rate was 19% among 227 sera collected from asymptomatic active homosexuals in 1984, against 10% among 40 sera collected in 1983. 8% positives were found among 98 patients with various types of viral hepatitis. In addition, 4% of 84 sera of individuals from Equatorial Africa were positive. No positives were found among 15 sera of individuals from other African regions, among 32 sera of persons from various regions of Asia, and among 203 Swiss blood donors. These results demonstrate the high and increasing rate of HTLV-III infection among groups at risk for AIDS, and suggest that HTLV-III-related diseases will be a serious problem in the years ahead.

Acquired Immunodeficiency Syndrome↗
PubMed1985

[Antibiotic therapy in bronchopulmonary infections].

The causative agent of lower respiratory tract infection cannot always be determined even with invasive techniques. In most clinical situations an empirical choice of antibiotics is indicated, if only for early institution of therapy. Next to the often misleading clinical picture, consideration of the epidemiological setting and specific risk of underlying diseases is of value in selecting empirical therapy.

Anti-Bacterial Agents↗
PubMed1982

[Ventricle rupture in myocardial infarction].

22 patients with rupture of the heart after myocardial infarction in the years 1974-1978 were compared with a matched sample of other patients with infarction. No increase in rupture rate was observed under present-day intensive care methods over the time period, nor did early heparin administration in one of the institutions involve increased risk of subsequent rupture.

Aged↗
PubMed1982

[Toxic shock syndrome in pyogenic arthritis].

Two cases are reported of toxic shock syndrome in patients with pyogenic arthritis due to Staph. aureus with proven production of enterotoxin F and pyogenic exotoxin C. An ischemic complication of both lower extremities in one of the patients may be related to the use of a heparin-dihydroergotamine combination for postoperative prophylaxis of deep vein thrombosis.

Adult↗
PubMed1982

[Acquired immunologic deficiency syndrome, opportunistic infections and homosexuality. Presentation of 3 cases studied in Switzerland].

Three cases of multiple opportunistic infections in previously healthy homosexual males were observed in 3 different University Hospitals in Switzerland. Two of the patients died. Infections were multiple, with P. carinii pneumonia (3 cases), chronic mucocutaneous ulcers probably due to Herpes simplex virus (2 cases), mucosal candidiasis (2 cases) and disseminated infections due to cytomegalovirus (1 case) and Mycobacterium avium (1 case). All patients had depressed cellular immunity with marked lymphopenia. These cases are similar to those recently observed in the United States, but two of the patients had never been to the USA although both had vacationed in Haïti where the syndrome has been described. These patients illustrate that this new syndrome should also be suspected outside the USA when a patient (especially a male homosexual) presents with persistent fever of unknown origin and develops opportunistic infections without obvious underlying disease.

Adult↗
PubMed1981

[Practical problems in the prevention of endocarditis].

Prophylactic antibiotic coverage of all interventions with a high risk of bacteremia is accepted practice in patients with valvular heart disease. A true cost-benefit ratio, however, has not been possible to demonstrate due to the low risk involved in these procedures, and therefore the current recommendations rely on experimental work with laboratory animals. Full application of these findings in patients is difficult and even so incapable of preventing the majority of cases of infective endocarditis.

Animals↗
PubMed1977

[Intramuscular injections and activity of serum creatine phosphokinase. Histopathological study in animal experiments].

In healthy Labrador dogs a single intramuscular injection of benzoctamin, diazepam and pethidin leads to a distinct increase in serum-creatine-phosphokinase (SCK) activity, whilst a single intramuscular injection of physiologic saline has no effect whatsoever. Intravenous injection of an identical dose of the above-mentioned drugs leaves SCK activity unchanged. Muscle specimens of the injection site, excised 5 days after intramuscular injection of the same drugs, display muscle cell necrosis, macrophage proliferation and reparative changes. The impressive histological alterations point to the striated muscle cell as a probable source of the increase in SCK activity (MM fraction).

Animals↗