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J Sassard

Publications and source records attributed to J Sassard.

257 records · Page 15Linked to original sources
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Vasopressin and oxytocin in genetically hypertensive rats of the Lyon strain.

To investigate the role of arginine vasopressin (AVP) in genetic hypertension, we measured 24-h urinary volume, osmolality, and 24-h AVP excretion, as well as pituitary and pineal AVP and oxytocin levels, in genetically hypertensive (LH), normotensive (LN), and low blood pressure (LL) 5-and 45-week-old female rats of the Lyon strains. We also determined vascular sensitivity to AVP, norepinephrine, and angiotensin II in 6- and 21-week-old rats. AVP secretion was increased in both LH and LL rats compared with LN controls. Previous reports of increased AVP secretion in spontaneously hypertensive rats have suggested that AVP might play a role in high blood pressure. The existence of a similar increase in LL rats indicates that genetic hypertension of LH rats is not related directly to their increased AVP secretion. Furthermore, the vascular sensitivity to AVP was not specifically enhanced in 21-week-old LH rats compared with LN and LL controls. This study provides evidence against a major role of vasopressin in the genesis and maintenance of high blood pressure in this model of experimental hypertension, and emphasizes that the choice of controls in such investigations is of crucial importance.

Angiotensin II↗
PubMedDate not supplied

[Pharmacokinetics of 35S-furosemide in experimental kidney failure in the rat].

Pharmacokinetics of 35S-Furosemide were determined after a single intravenous administration (2,5 mg/kg) in rats with experimental renal insufficiency due to figure in S-ligation of the kidney or subcutaneous injection of uranyl nitrate (10 mg/kg) in uninephrectomized animals. In the rat the pharmacokinetics of Furosemide obeyed to a two-compartment model. The distribution parameters were not markedly altered by renal insufficiency while the elimination ones were decreased proportionally to the renal impairment. Since these data are in close agreement with those observed in humans such an experimental study allows to predict the changes exhibited by patients with impaired renal function. Therefore the use of rats with renal insufficiency might be of value to design the safest protocol which has to be used for the pharmacokinetic study of drugs with low therapeutic index in patients with renal diseases.

Animals↗
PubMedDate not supplied

[Clinical significance of plasma renin, testosterone, 17-alpha-hydroxyprogesterone and ACTH activities in the treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. A review of 31 cases].

Measurements of urinary steroids do not allow a precise supervision of the evolution and treatment of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Thirty-one cases with a 2 year follow-up allowed a trial of estimation of the progress that could be obtained with plasmatic dosages of renine, testosterone, A.C.T.H. and 17-hydroxyprogesterone (17-O.H.P.) activities. The best way for reaching diagnosis is presently 17-O.H.P. However, the amplitude and variability of nyctemeral changes of 17-O.H.P. as well as A.C.T.H. activities do not allow to use these two dosages for a precise supervision of therapeutic effects. On the contrary, the dosage of testosterone allows the appreciation of the risk of virilization and its reliability gives a precise control of the effects of steroid therapy. The dosage of the renine activity disclosed unknown or not well controlled sodium-losses, and allowed to adjust the dosage of 9-alpha-fluorohydro-cortisone, while limiting glucocorticosteroids. It gave also evidence of the usefulness of prolonged steroid therapy until the end of the growth period.

Adolescent↗