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Biomedical subjects

J Sany

Publications and source records attributed to J Sany.

At least 199 records · Page 11Linked to original sources
PubMed1981

[Serum beta-2-microglobulin in multiple myeloma. Practical value].

The concentration of serum, beta-2-microglobulin (S beta 2m) and the ratio measured S 2m/theoretical S beta 2m M/TH were evaluated in 69 patients with multiple myeloma (MM) and compared with healthy subjects and with patients with a benign monoclonal gammapathy. The concentration of S beta 2m and the ratio S beta 2m M/TH are higher in multiple myeloma than in controls and are strongly correlated with the plasma cell mass On the other hand, no difference was noted concerning the S beta 2m and the ration S beta 2m M/TH between benign monoclonal gammopathy and multiple myeloma at stage I of Durie and Salmon. Under chemotherapy, the variations in concentrations of S beta 2m and of the ratio S beta 2m M/TH are strongly correlated with those of the tumour mass. Beta 2m is not very useful for the differential diagnosis between benign monoclonal gammapathy and multiple myeloma. Beta 2m is very useful in the prognosis of MM, permitting one to assess accurately the tumour mass and the response to treatment, particularly in cases of deficiency of the usual markers.

Beta-Globulins↗
PubMed1981

[Osteoarticular manifestations of brucellosis. Current aspects].

The authors report 118 cases of brucella osteoarthritis, of which 61 were observed over the last ten years. The most frequent localisations are spinal (53.4%), sacro-iliac (34.5%) and coxofemoral (15.5%). The clinical aspects are not very specific. The general signs, frequent during coxitis and to a lesser degree in spondylodiscitis, are rare during sacro-iliac involvement. The radiological appearance is mainly characteristic in the spine. The diagnosis is usually made in the laboratory, depending on a search for specific antibodies and delayed hypersensitivity tests. Treatment requires the use of intra-tissular and intra-cellular penetrating antibiotics (tetracycline and rifampicin) administered for a long period. The course usually leads to a cure without sequelae.

Arthritis, Infectious↗
PubMed1981

[Effect of the manner of the response to chemotherapy on the prognosis of myeloma. Preliminary study].

The tumor mass regression following the first course of treatment (T1), the time to greater than or equal to 50% tumor regression (TR 50%) and the time to maximum regression (t) were assessed in 29 out of 55 multiple myelomas (MM) successfully treated with alkylating agents. According to t, TR 50% and T1 values, 3 distinctive categories of responsive patients were separated: 1) fast responsive patients (= t less than or equal to 2 months, 48% of cases); 2) intermediate responsive patients (= 3 less than t or 12 months, 38%); 3) and slow responsive patients (= t greater than 12 months, 14%). The first remission duration was shown to be highly related to t (p less than .001), TR 50% (p less than .01) and T1 (p less than .05), the shortest remissions being observed in fast responsive patients. In relapse, the tumor doubling time (TD) was correlated with t, TR 50% and T1 (p = .05), the shortest TD being observed in fast responsive patients. It was shown that pure Bence-Jones and hypercalcemic myelomas were the fastest responsive patients.

Aged↗
PubMed1980

Myeloma bone marrow acid phosphatase staining: a correlative study of 38 patients.

Acid phosphatase (AP) activity of plasma cells was studied in 38 patients with multiple myeloma (MM). The average activity per cell was strong (mean score = 2.42; maximum score = 4) and the percentage of positive cells was greater than 90% in over 71% of patients. The average AP activity per cell was higher prior to treatment (3.06 +/- 0.53) compared to relapse (2.48 +/- 0.77) and remission (1.81 +/- 1.02 (p less than 0.05 and p less than 0.01, respectively). In correlation of AP activity with clinical features at the time of the study, the only significant difference was between kappa and lambda subtype. Patients with lambda MM had a higher average AP activity per cell in remission (2.71 +/- 0.43) as opposed to kappa MM (1.17 +/- 1.06, p less than 0.05 for difference). AP activity was not significantly correlated with degree of bone involvement. However, activity seemed to be a good marker of disease activity.

Acid Phosphatase↗
PubMed1980

[Lumbar intraspinal tumors seen in a rheumatological context].

On the basis of a 50 case study, the authors insist on the difficulty of diagnosing lumbar intraspinal tumors seen in a rheumatological context. The increase in pain and spine and spine stiffness at night are the most significant semiological characteristics. A generally slight neurological deficiency is noted in 29 cases (58%) and 21 patients (41%) have a clinical picture identical to that of discal hernias. X-rays of the lumbar spine show signs of bone erosion in 24% of cases. Lumbar puncture furnishes major indications in 85.5% of cases. Contrast testing almost always demonstrates the presence of a tumor. Lumbar intraspinal tumors include a very wide variety of histological types, among which neurinomas, ependymomas and extra-dural malignant tumors are the most frequent.

Adolescent↗
PubMed1980

[Value of successive chemotherapy in multiple myeloma of bone. Prospective study over 4 years].

In order to study the response of patients with multiple myeloma of the bones (MM) to various anti-cancer drugs (Melphalan M, Cyclophosphamide Cy, Nitrosourea NU, Vincristine V, Adriamycine A and Prednisone P), 70 MM received the following treatment : 1) Induction therapy : a) M and P or b) M and Cy and P ; 2) Levelling with partial or complete response : V Cy P (in case a) or V M Cy P (in case b) ; 3) Relapse : A and NU. The following results were obtained : 1) Only 42.6% of patients respond to induction therapy ; 2) Fewer than 10% of patients showing a response reach a second levelling with Vincristine ; 3) 50% of those not showing a response reach a levelling between --20 and --50 and have prolonged survival ; 4) Only 20% of non responders are improved by Cy P or A and NU. The median actuarial survival is 42 months. Among the responders two poor prognosis factors must be underlined : hypercalcemia and the speed of response.

Aged↗
PubMed1980

[Cellular immunity during ankylosing spondylitis].

A study of cell immunity was carried out in 23 patients with ankylosing spondylitis, 17 HLA B27 +, 6 HLA B27 --, 5 donors of normal blood carrying HLA B27 antigen and 50 controls, 7 methods were used together for a study of the markers of the blood lymphocyte membranes: rosette E, rapid rosette E, anti HTLA + X, surface immunoglobulins, PEA gamma and BEA gamma rosettes, determination of the monocytes after peroxidase staining. Stimulation of lymphocytes with mitogens (PHA, Con A, PWM) were carried out. There exists an increase in blood lymphocytes carrying HTLA + X in patients with ankylosing spondylitis HLA B27 and also in healthy carriers of the same antigen. During ankylosing spondylitis with HLA B27 --, a statistically significant reduction in T lymphocytes forming E and E rapid rosettes was observed; finally, a rise in the levels of circulating immune complexes detected by the PEG --C4 method was noted. The significance of these facts is discussed.

Adult↗
PubMed1979

[Prostatic osteosis. Retrospective study of 110 cases treated with high-dose estrogens].

On the basis of 110 prostatic osteoses that were histologically proven, constantly painful and demonstrated by X-ray, treated by early estrogenotherapy using very high doses, backed up by a high-dose maintenance estrogenotherapy, the authors study the clinical, radiological, histological and biological profile of this metastatic cancer, as well as the response to treatment. The median actuarial survival time of the patients studied is 18.5 months. No statistically significant prognostic correlation was found. Only patients who are clinically estrogen-sensitive, are suffering from bone metastases without a combined visceral conditions, and have a normal initial rate of alcaline phosphates, tend to have a better prognosis (median actuarial survival 31 months versus 18.5 months for the overall population).

Adult↗
PubMed1979

[Suppressor cells of mitogen responses during rheumatoid polyarthritis].

The suppressor activity of mononuclear cells of the peripheral blood (MCPB) during rheumatoid polyarthritis (RP) was studied using experimental protocole. The MCPB stimulated in vitro by concanavaline A (Con A) are capable of suppressing the mitogenis response of autologus cells; moreover, the short-lived spontaneous suppressor cells disappear during 24 hour in vitro incubation that determines an increase in the proliferative response of the incubated cells for 24 hours. In two of the six RP studied, the suppressor activity generated Con A and the spontaneous suppressor activity are nul. Culture experiments with the MCPB of PR and control subjects show that this defect in suppressor activity is more related to a problem in the generation of suppressor cells than to a deficiency in the response to suppressor signals.

Arthritis, Rheumatoid↗
PubMed1979

[Physiopathology of rheumatoid psoriasis].

The physiopathology of rhumatoid psoriasis (RP) is poorly known. Besides the genetic factors we study immunological disorders from a series of 51 cases. We found mainly an increase of serum IgA, a decrease of IgM, a low level of circulating immune complexes, sometimes IgG type antiglobulin factor (very seldom IgM type, which explains the sero-negativity) seldom antinuclear antibodies; we found also a diminution of T lymphocytes detected by a decrease of E rosette - forming cells and an increase of the lymphocyte subpopulation forming high avidity EA rosettes, whereas the mitogenic response is normal or slightly decreased in the presence of Con A (not significant). A increased frequency of HLA DRW5 and DRW2 was found but too few cases were studied to make possible a definite conclusion. This immunopathologic profile is compared to that of psoriasis with anthropathy. The relevance of immune disorders in the physiopathology of RP is discussed.

Adolescent↗
PubMed1979

[Multiple myeloma of bones. Retrospective study of prognostic factors based on a series of 243 patients].

The authors have made a retrospective study of 243 cases of multiple myelomas, most of them treated with alkylating agents. The average age at the time of diagnosis was 65 years (+ 10). The ratio of the sexes was 1 : 1. Seventy two per cent of the patients had a bone rating of 2 or 3 according to the criteria of Durie and Salmon. Fifty-eight per cent of the patients were anemic (Hg 12 g per cent), with less than 15 per cent being leucopenic or thrombopenic. Hypercalcemia (105 mg 0/00) was noted in 27 per cent of cases. The distribution of immunochemical types is as follows : IgG, 51.5 per cent; IgA, 28 per cent; pure Bence Jones, 20.5 per cent. The respective percentages of kappa and lambda light chains were 64.2 per cent and 35.8 per cent. In this series, nearly 80 per cent of the patients were at phase III according to the classification of Durie and Salmon, and 30.8 per cent at phase B. The median survival, including all phases, increased from 8 months without alkylating agent, to 20 months with melphalan and/or cyclophosphamide. The factors influencing the survival of the patients treated were age, the hemoglobin level, calcemia, renal deficiencies, the immunochemical type, the stage of the disease, and the response to alkylating treatment. The value of these different prognostic factors is discussed.

Adult↗