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Biomedical subjects

J Salvaggio

Publications and source records attributed to J Salvaggio.

59 records · Page 4Linked to original sources
PubMedDate not supplied

Effects of asbestos and beryllium on release of alveolar macrophage enzymes.

Rabbit alveolar macrophages were exposed in culture medium to asbestos, beryllium sulfate, and beryllium oxide. The specific activities of the lysosomal hydrolases, acid phosphatase beta-N-acetylglucosaminidase and beta-glucuronidase plus the glycolytic enzyme, phosphohexose isomerase were determined in the medium, whole-cell homogenates, mitochondrial fractions, and supernatant. These hydrolases increased significantly in the medium but not in the mitochondrial fraction of cells exposed to dusts. Asbestos and beryllium sulfate were highly cytotoxic for alveolar macrophages in vitro and the data suggested that these agents were not associated with an increase in enzyme synthesis but rather a direct cytotoxic effect at the macrophage membrane level. For induction of enzyme release in vitro, a higher concentration of beryllium oxide was needed when compared with asbestos and beryllium sulfate. The cytotoxicity and enzyme release induced by these agents may represent an important nonspecific mechanism by which they induce inflammation and perhaps local proliferation of fibroblasts.

Acetylglucosaminidase↗
PubMedDate not supplied

Use of burn intensive care unit gymnasium as an adjunct to therapy.

One primary goal for patients with burns is to prevent loss in range of motion and function in the involved extremities. Because therapies were provided only on weekdays at our facility, the burn team designed a gymnasium that was built in the burn unit where patients can carry out their exercise programs after hours and on weekends. Patients assume responsibility to complete their occupational and physical therapy assignments, in addition to their other scheduled therapy sessions. The development of the burn intensive care unit gymnasium has increased the opportunity for patients to improve their range of motion and overall functional status. We have also noted that patients feel a greater sense of motivation and accomplishment when they are invited to take more control of their recovery. Assuming responsibility for their programs enables patients to achieve their goals, thus increasing their self-esteem after what is often a very devastating injury.

Burn Units↗