Biomedical subjects

J Salvá

Publications and source records attributed to J Salvá.

At least 19 recordsLinked to original sources

PubMed2001

Structure and cytotoxicity of new polyhydroxylated sterols from the Caribbean gorgonian Plexaurella grisea.

The gorgonian Plexaurella grisea contains the new steroids 9-hydroxygorgosterol (1), 9,11 alpha,14-trihydroxygorgosterol (2), 5 beta,6 beta-epoxyergost-24(28)-ene-3 beta,7 beta-diol (3), ergost-24(28)-ene-3 beta,5 alpha,6 beta,7 beta-tetrol (4), an unseparable 1:1 mixture of the epimers (25R) and (25S)-26-acetoxy-3 beta,5 alpha-dihydroxyergost-24(28)-en-6-one (5/6), and seven related, known compounds (7-13). The structures of these new compounds were defined by spectroscopic analysis. All the compounds (1-13) isolated from P. grisea were tested against P 388, A 549, and HT 29 tumor cell lines. Compounds 3, 5/6, and 12 exhibited selective activity against the HT 29 cell line (ED(50) = 0.1 microg/ml).

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PubMed2001

New acyclic sesquiterpenes and norsesquiterpenes from the Caribbean Gorgonian Plexaurella grisea.

The gorgonian Plexaurella grisea from Punta Cana, Dominican Republic, contains five new acyclic sesquiterpenes, (3E,5E)-3,7,11-trimethyl-9-oxododeca-1,3,5-triene (3), (3Z,5E)-3,7,11-trimethyl-9-oxododeca-1,3,5-triene (4), (3E)-6-acetoxy-3,11-dimethyl-7-methylidendodeca-1,3,10-triene (5), (3E,5E)-7-hydroxy-3,7,11-trimethyldodeca-1,3,5,10-tetraene (6), and (3E,5E,9E)-8,11-diacetoxy-3,7,11-trimethyldodeca-1,3,5,9-tetraene (7), and two new linear norsesquiterpenes, (2E,4E,7Z)-2,6,10-trimethylundeca-2,4,7,9-tetraenal (8) and (2E,4E)-2,6,10-trimethylundeca-2,4,9-trienal (9), in addition to the known compounds 1, 2, and 10. The structures of the new compounds 3-9 were elucidated by interpretation of spectroscopic data. In general, the new compounds are mildly cytotoxic against tumor cell lines, and although norsesquiterpene 8 was inactive, norsesquiterpene 9 exhibited the greatest and selective activity against the P-388 tumor cell line.

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PubMed2000

Isolation and structure elucidation of new cytotoxic steroids from the gorgonian Leptogorgia sarmentosa.

The gorgonian Leptogorgia sarmentosa contains three new steroids, (20S)-20-hydroxycholestane-3,16-dione (1), (16S, 20S)-16,20-dihydroxycholestan-3-one (2), and (20S)-20-hydroxycholest-1-ene-3,16-dione (3) together with a known related compound (4). Their structures were defined by spectroscopic analysis. The new steroids exhibited significant cytotoxicity against four tumor cell lines (ED50 = 1 microg/ml).

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PubMed1998

New metabolites from the sponge Spongia agaricina.

The sponge Spongia agaricina from Tarifa, Cadiz, Spain, contains two new 9,11-secosterols, [3-0-deacetylluffasterol B (1) and 3-0-deacetyl-22,23-dihydro-24,28-dehydroluffasterol B (2)] and two new sesterterpenoids [12,16-di-epi-12-0-deacetyl-16-0-acetylfuroscalarol (3) and 16-epi-scalarolbutenolide (4)], in addition to the known compounds 5-15. The structures of all compounds were elucidated by interpretation of' spectroscopic data. The metabolites 1-3 showed significant cytotoxicity against four tumor cell lines (C50 1 microgram/mL).

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PubMed1998

New cyclic peroxides from the Philippine sponge Plakinastrella sp.

Three new cyclic peroxides 5-7 and a new carboxylic acid ester 8 were isolated as minor metabolites from the hexane extract of a Plakinastrella species from the Philippines. The structures of compounds 5-8 were elucidated by interpretation of spectral data and by chemical interconversion, and the absolute stereochemistry of peroxide 6 was determined by application of Mosher's method to a derivative. Although the major compounds in the sponge showed activity against Candida albicans prior to decomposition, the minor metabolites 5-8 are essentially inactive.

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PubMed1997

3-Epi-aplykurodinone B, a new degraded sterol from Aplysia fasciata.

The anaspidean mollusk Aplysia fasciata from Río San Pedro (Cádiz, Spain) contains the known degraded sterols aplykurodinone B (2) and aplykurodin B (4) together with the new 3-epi-aplykurodinone B (5). The structure of 5 was elucidated by interpretation of spectral data, and its relative stereochemistry was established using NOEDS experiments. The new compound 5 exhibited cytotoxicity against four tumor cell lines.

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PubMed1992

Identification of the new 10,15-eicosadienoic acid and related acids in the opisthobranch Haminaea templadoi.

The free fatty acids of the Mediterranean opisthobranch Haminaea templadoi were isolated and characterized, revealing the presence of the new 10,15-eicosadienoic acid [1] and several unusual cis delta 6 monoenoic acids, such as (Z)-6-tetradecenoic acid, (Z)-6-pentadecenoic acid, and (Z)-6-heptadecenoic acid. These results reveal some previously unrecognized fatty acids in mollusks.

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PubMed1974