Search PubMed⌕ Search

Biomedical subjects

J Salmon

Publications and source records attributed to J Salmon.

154 records · Page 9Linked to original sources
PubMedDate not supplied

[Autoimmune diseases: an aberrant behavior of our immune system?].

If autoimmunization seemed unthinkable at the beginning of this century, this phenomenon is now widely recognized. After a short recall of the immune system mechanism, we describe the recent concept allowing to explain the auto-antibody synthesis and their role in human pathology. The therapeutical strategies of autoimmune diseases are briefly evoked.

Animals↗
PubMedDate not supplied

[Antineutrophil cytoplasmic antibodies (ANCA) in inflammatory diseases of the digestive tract].

Antineutrophil cytoplasmic antibodies have recently been demonstrated in sera of patients with inflammatory bowel disease. We are reporting here our experience among 94 patients with Crohn's disease and 25 with ulcerative colitis. The indirect immunofluorescence assay with alcohol fixed neutrophils has been used. The presence of antineutrophil cytoplasmic antibodies was significantly associated to the ulcerative colitis 61% VS 17% (p < 0.001). The fluorescence had a perinuclear pattern among all but one suffering from ulcerative colitis. Among the patients suffering from ulcerative colitis there was no relationship between the presence of antineutrophil cytoplasmic antibodies and the activity or the localisation of the disease. Among the 9 patients operated for their ulcerative colitis, 4 were ANCA positive and remained so after proctocolectomy. The existence of antineutrophil cytoplasmic antibodies is useful for the diagnosis of some unclassifiable colitis. Their presence may be used as an argument in favour of some disturbances of the immunoregulation of the disease.

Adult↗