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Biomedical subjects

J Salisbury

Publications and source records attributed to J Salisbury.

46 records · Page 3Linked to original sources
PubMed1987

Ruptured abdominal aortic aneurysm in Marfan's syndrome.

A rare case of ruptured abdominal aortic aneurysm in Marfan's syndrome is described. The patient was treated successfully with a straight aortic tube graft. Histology of the aneurysm wall showed changes typical of cystic medial necrosis.

Adult↗
PubMed1986

Treatment of common and plantar viral warts with human lymphoblastoid interferon-alpha--pilot studies with intralesional, intramuscular and dermojet injections.

Pilot studies with human lymphoblastoid interferon-alpha(Wellferon), utilizing the intralesional, intramuscular and dermojet routes, have been performed in 39 patients with common and plantar viral warts resistant to conventional therapy. Clinical efficacy, local and systemic toxicity, and effects on haematological and clinical chemistry parameters has been measured. Our results indicate that the intralesional route is the most favourable as it combines an acceptable therapeutic ratio with a procedure that may be performed quickly and with no prior preparation of the lesion.

Adolescent↗
PubMed1986

Acropustulosis of infancy.

Acropustulosis of infancy is a syndrome characterized by recurrent pruritic acral vesicopustules. It occurs primarily in black male infants and hitherto has been described mainly in the North American literature. We describe four cases seen in London. This entity, therefore, should be recognized in the U.K., particularly in the differential diagnosis of infantile scabies.

Foot Dermatoses↗
PubMed1985

A nucleus-basal body connector in Chlamydomonas reinhardtii that may function in basal body localization or segregation.

We have isolated a nucleus-basal body complex from Chlamydomonas reinhardtii. The complex is strongly immunoreactive to an antibody generated against a major protein constituent of isolated Tetraselmis striata flagellar roots (Salisbury, J. L., A. Baron, B. Surek, and M. Melkonian, J. Cell Biol., 99:962-970). Electrophoretic and immunoelectrophoretic analysis indicates that, like the Tetraselmis protein, the Chlamydomonas antigen consists of two acidic isoforms of approximately 20 kD. Indirect immunofluorescent staining of nucleus-basal body complexes reveals two major fibers in the connector region, one between each basal body and the nucleus. The nucleus is also strongly immunoreactive, with staining radiating around much of the nucleus from a region of greatest concentration at the connector pole. Calcium treatment causes shortening of the connector fibers and also movement of nuclear DNA towards the connector pole. Electron microscopic observation of negatively stained nucleus-basal body complexes reveals a cluster of approximately 6-nm filaments, suspected to represent the connector, between the basal bodies and nuclei. A mutant with a variable number of flagella, vfl-2-220, is defective with respect to the nucleus-basal body association. This observation encourages us to speculate that the nucleus-basal body union is important for accurate basal body localization within the cell and/or for accurate segregation of parental and daughter basal bodies at cell division. A physical association between nuclei and basal bodies or centrioles has been observed in a variety of algal, protozoan, and metazoan cells, although the nature of the association, in terms of both structure and function, has been obscure. We believe it likely that fibrous connectors homologous to those described here for Chlamydomonas are general features of centriole-bearing eucaryotic cells.

Calcium↗
PubMed1985

Implications of a sclerotherapy program for the medical and surgical care of bleeding in portal hypertension.

The results of endoscopic sclerotherapy are promising and, at first sight, this technique offers a relatively simple and widely available method of achieving definitive control and preventing rebleeding from the esophageal varices. While it is an attractive option to operation, there is a small but significant group of patients, both at initial presentation and follow-up examination, in whom sclerotherapy is inappropriate. It remains to be determined whether shunt operation or a gastric vascularization procedure is superior. It must be remembered that surgical intervention may be required for a number of nonvariceal complications which may arise in patients with portal hypertension. Despite the apparent simplicity of endoscopic sclerotherapy, the management of these patients unquestionably requires a team of physicians, surgeons and nurses with back-up facilities from other personnel who are experienced in this problem, if mortality is to be kept to a minimum. The management of bleeding esophageal varices requires considerably more than a simple injection of sclerosant into a varix and a chronic sclerotherapy program imposes a large and inevitably increasing workload on a gastroenterologic unit.

Anesthesia↗
PubMedDate not supplied

Effect of perfusate albumin on organ viability and vascular responses in the in vitro dual-perfused rat liver.

Inclusion of albumin in the perfusate has been previously shown to be detrimental to liver function, but its effect on hepatic vascular reactivity remains unknown. The aim of this study was to determine the effects of albumin on hepatic arterial vascular reactivity and liver viability in the isolated dual-perfused rat liver. A total of 12 rat livers were perfused with Krebs-Bülbring buffer without (Group 1) and with (Group 2) addition of 1% bovine serum albumin (BSA) through the hepatic artery and portal vein for up to 5 h. Hepatic arterial responses to acetylcholine and sodium nitroprusside were studied at 30-min intervals. Liver viability was assessed by bile volume production, release of aspartate serine aminotransferase (AST) and lactic acid dehydrogenase (LDH), and histological examination. Hepatic arterial responses to acetylcholine were significantly attenuated in Group 2. No significant differences in sodium nitroprusside responses were noted. However, bile volume production in Group 2 was significantly decreased compared to Group 1. Effluent AST and LDH release increased significantly in Group 1 but not in Group 2. Histological results showed that sinusoidal endothelial cells and hepatocytes were well preserved without significant deterioration in either group, although there was a marked decrease in vasodilatation to acetylcholine in Group 2. This data suggested that the presence of albumin in the perfusate did not improve retention of smooth muscle reactivity and reduced endothelium-dependent vasodilatation and bile volume production during perfusion. However, improved liver parenchymal cell function was observed.

Acetylcholine↗