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Biomedical subjects

J Salducci

Publications and source records attributed to J Salducci.

At least 37 records · Page 2Linked to original sources
PubMed1991

Manometric and radiologic investigations and biofeedback treatment of chronic idiopathic anal pain.

In 12 patients suffering from chronic idiopathic anal pain, the rectosphincteric function was studied using manometric and x-ray techniques. The results of manometric investigations were compared with those obtained in 12 healthy volunteers. In all patients, the resting pressure in the anal canal was significantly higher than in control subjects. In 10 patients, defecography revealed abnormalities of the pelvic muscles. We treated the patients by using biofeedback techniques, consisting of voluntary modifications of the state of contraction of the external sphincter. In all cases, pain disappeared after a mean of eight biofeedback training sessions. When noxious manifestations had disappeared, manometry showed a significant decrease in the anal canal resting pressure. Our results indicate 1) that chronic idiopathic anal pain is associated with abnormal anorectal manometric profiles, probably resulting from a dysfunctioning of the striated external anal sphincter, and 2) that biofeedback training is an effective treatment for chronic idiopathic anal pain.

Adult↗
PubMed1990

Primary malignant melanoma of the esophagus.

This report describes a case of primary malignant melanoma of the esophagus in a 66-year-old man treated by esophagogastrectomy. Radiographic, endoscopic, echoendoscopic and histological features are given and a short review of the literature is presented.

Aged↗
PubMed1989

[Treatment of achalasia by pneumatic dilatation].

Between 1979 and 1988, 60 patients with achalasia were treated by pneumatic dilatation under general anaesthesia, using the Rider-Moeller apparatus. The diagnosis rested on clinical, radiological, manometric and endoscopic criteria. These 60 patients underwent a total of 99 dilatations: 63.3 per cent were dilated once and 37.7 per cent were dilated several times. Forty seven of the 60 patients were followed up for more than 12 months (mean: 44 months): 2 of them (4.2 per cent) had to be operated upon, while 45 (95.7 per cent) are asymptomatic. Immediate complications were perforation in one case and cardial fissure in another; both were treated medically and cured. There was no oesophagitis or peptic stenosis, and no patient died. These results are compared with those found in the literature. The authors underline the simplicity, safety and effectiveness of pneumatic dilatation and suggest that it should be used as first-line treatment of achalasia, surgery being performed only when dilatation fails.

Adolescent↗
PubMed1989

Non-cholinergic neural excitation of the human rectum induced by acetorphan, an inhibitor of enkephalinase.

We have studied the effects of acetorphan, an inhibitor of enkephalinase, on the electrical activity of human rectum. Acetorphan activated the rectum of healthy volunteers by inducing bursts of spike potentials, this activation might become cyclical. In contrast, this drug failed to modify the motility of the aganglionic portion of the rectum in one case of Hirschsprung's disease, indicating that the effect of acetorphan involves the intramural plexuses. Activation of the rectum persisted in spite of the blockade of the cholinergic excitatory pathways by atropine, which confirms the existence of an excitatory non-cholinergic mechanism for the rectum. Our results also suggest that the neurotransmitter responsible for this effect is continuously released by the nervous structures implicated in the control of rectal motility. Immunohistochemical data show that the rectum is supplied by a rich enkephalinergic innervation.

Adult↗
PubMed1989

[Celiac disease, autoimmune cirrhosis, chronic pancreatitis: apropos of a triple association].

We report the case of a 60 year old lady suffering from celiac disease and autoimmune cirrhosis who developed exocrine pancreatic insufficiency with canalicular lesions consistent with chronic pancreatitis. Celiac disease is known to be associated with either pancreatic insufficiency or liver disease, but association of all three diseases has not yet been described. We suggest that chronic pancreatitis be added to the list of idiopathic inflammatory pancreatitis of possible autoimmune origin, enabling to explain the pathophysiology of all three disorders with one hypothesis.

Autoimmune Diseases↗
PubMed1987

Effects of morphine on electrical activity of the rectum in man.

1. The effects of morphine on the electrical activity of the human rectum were investigated. 2. In healthy volunteers, morphine (0.04-0.16 mg/kg, i.v.) induced spike activity that could become cyclical. 3. All the effects of morphine were antagonized by naloxone (0.03-0.2 mg/kg, i.v.), but not blocked by atropine (0.007-0.014 mg/kg, i.v.). 4. In patients with spinal cord injury, morphine was observed to have similar excitatory effects. Spinal cord transection was complete in all patients, so that participation of supraspinal nervous structures in these effects could be ruled out. The sacral parasympathetic nervous centres could not have been involved in two patients in whom the medullary cone was also destroyed. The thoracolumbar sympathetic nervous centres were not completely destroyed in any of the patients, however, so that the possibility that these centres may have been involved cannot be entirely ruled out. 5. Morphine failed to activate an aganglionic rectum in a patient with Hirschsprung's disease, indicating that it had no direct effect on smooth muscle cells. It is therefore probable that morphine may have an effect on the intrinsic innervation.

Action Potentials↗
PubMed1984

[Retrograde endoscopic cholangiography after biliary surgery].

Retrograde cholangiography was conducted in 310 patients early or late after biliary system surgery. Principal indications for the investigation were angiocholitis (37% of cases), isolated jaundice (30%) or acute hepatic colic (17%). Biliary tract lesions were excluded in 7% of patients while in the remaining 93% it was possible to determine the precise cause of the disorder. In 30% of cases the disorder was unrelated to the previous operation or the lithiasic disease, whereas in 63% it was related to the latter (remaining or reformed stone, odditis) or to the surgical procedure (stenosis, common bile duct ligature or injury to main bile duct). These results, and those reported in the ligature, suggest that retrograde cholangiography can provide a precise diagnosis and ensure adapted therapy after biliary surgery.

Adult↗
PubMed1983

[Ajmaline-induced hepatitis. A case report with ultrastructural study].

The authors report the case of a patient with ajmaline hepatitis. The clinical presentation suggested angiocholitis; serum bilirubin concentration and the activity of alkaline phosphatase were markedly increased; serum transaminase activity was moderately increased; the prothrombin time remained normal. After interruption of the drug, the outcome was favorable, with complete recovery within 2 months. Histologic examination of a liver specimen obtained early after the onset of jaundice showed inflammatory cells in the portal tracts and mild hepatocytic lesions. Electron microscopy disclosed dilatation of the endoplasmic reticulum. The microfilamentous network of the hepatocytes was reduced and disorganized. Biliary canaliculi were enlarged with absent or blunted microvilli. There was evidence for passage of bile products from the biliary caniculi into the space of Disse. These aspects are reminiscent of those observed in animals after the administration of cytochalasin B. It is suggested that ajmaline may, in some patients, trigger an immune response which then alters the microfilamentous network of the hepatocytes, and may, thereby, produce cholestasis.

Aged↗