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Biomedical subjects

J Sainte Laudy

Publications and source records attributed to J Sainte Laudy.

9 recordsLinked to original sources
PubMed1994

[Importance of the lacrymal levels (total IgE, specific IgE and albumin) for the study of allergic conjunctivitis].

We have explored 67 subjects (41 women and 26 men) suffering from conjunctivitis and rhino-conjunctivitis. Prick tests, blood total and specific IgEs and total and specific IgEs and albumin in tears have shown positive prick tests for usual aero-allergens in 78% of the cases, an increase of albumin level in tears in 69% of the cases due to local inflammation and a local synthesis of IgEs in 33% of the cases. In four cases total and specific IgEs in tears were the only positive parameters in agreement with the clinical findings.

Adolescent↗
PubMed1993

Control of basophil degranulation.

We first present a linear compartmental model describing human basophiol degranulation by means of an antigen concentration. Then we study an optimal control problem associated to this linear compartmental model in presence of high dilutions. For solving this control problem we used the LAPLACE transform.

Antigens↗
PubMed1993

[Apropos of 2 cases of latex allergy with isolated ocular expression].

We present here two cases of latex allergy with ocular manifestations due to the use of condoms and the manipulation of rubber bands. In both cases the in vivo (prick tests) and the in vitro (RAST) testing were positive. In one of these two cases, the immunological tests performed in tears showed a local synthesis of latex specific IgE.

Condoms↗
PubMed1992

Basophil degranulation control.

We first present a global simulation model describing inhibition of human basophil degranulation by means of high dilutions. Then we study an optimal control problem associated to a non-linear compartmental model. This control is associated to an antigen concentration. For solving this control problem we used a dynamic programming method.

Basophil Degranulation Test↗
PubMed1988

[Blood histamine levels in patients infected with the human immunodeficiency virus].

Serum histamine levels are significantly lowered in patients with human immunodeficiency virus (HIV) infection. Treatment with zidovudine has no effect on histaminaemia, but HIV-positive patients with thrombocytopenic purpura who underwent splenectomy are known to have had a rise in serum histamine levels after the operation. This parameter might be used as prognostic factor in the evaluation of patients with HIV infection.

HIV Seropositivity↗
PubMed1983

[Immediate hypersensitivity to lacrimal gland proteins in sicca syndromes].

A biological study was conducted on tears from 20 subjects with a clinical sicca syndrome. Electrophoresis of lacrymal proteins, determination of lacrymal and salivary immunoglobulins G, and a human basophil degranulation test (HBDT) with a lacrymal gland extract as antigen were performed in each patient. Three different groups could be distinguished: a group with normal electrophoresis and normal HBDT corresponding to hyposecretion; a second group with abnormal electrophoresis and negative HBDT corresponding to an inflammatory state of the lacrymal gland; and a third group with abnormal electrophoresis and positive HBDT corresponding to a deficit in synthesis function of the lacrymal gland. These findings demonstrate that HBDT with lacrymal gland extract as antigen is a reliable means of diagnosis of the sicca syndrome.

Adult↗