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Biomedical subjects

J Sailer

Publications and source records attributed to J Sailer.

25 records · Page 2Linked to original sources
PubMed1977

[Seroepidemiological investigations on the prevalence of chlamydial antibodies in the human (author's transl)].

1,075 serum samples taken at random from blood donors and 524 samples from patients were investigated with a group-specific antigen for chlamydial antibodies. Antibodies were detected in 9.9% of the blood donors and in 25.7% of the patients, with titers from 1:5 to 1:160 in the former group and up to 1:640 in the latter group. In general, patients had significantly higher titers than blood donors. More attention should therefore be paid to the possible role of Chlamydia in infections of unknown origin.

Antibodies, Bacterial↗
PubMed1977

[Experimental investigations on the immunity development in irradiated mice after local and parenteral immunization with tetanus-toxoid (author's transl)].

Using the "tetanus-mouse" model the differences in immunity development between animals exposed to irradiation (300 R and 400 R) and animals not exposed to irradiation after nasal and subcutaneous vaccination was investigated. Immunization was carried out 1, 3, 6 and 10 days before and after exposure to irradiation. Efficacy of immunization was tested by challenge with 10 X LD50 tetanus-toxin and by antitoxin determination with L+-method. The degree of the immune response was dependent on 1. the irradiation dose, 2. the interval between active immunization and the ensuing or preceding irradiation, 3. the mode of vaccination (local or parenteral) and 4. the vaccination dose.

Animals↗
PubMed1976

[A new possibility of "non-parenteral" (local) vaccination: immunization per wound (author's transl)].

Hitherto the term "non-parenteral" (local) vaccination meant all those modes of vaccination where the vaccine is applied on the skin or the mucous membranes. The most common types of local immunization are oral and nasal vaccination. Using model studies with the mouse immunization per wound was investigated as an alternative mode of vaccination. Immunization was done with tetanus-toxoid, efficiency was tested by challenge with 10 LD50 tetanus toxin. For immunization per wound only slightly higher antigen doses are necessary compared with subcutaneous immunization. A single subcutaneous vaccination with 2 Lf tetanus-toxoid and a single application per wound of 10 Lf resulted in the same efficiency index of 100. Immunization per wound has to be carried out immediately after injury. It seems to be optimal within the first 3 to 5 hours. At a later time the same efficiency index can only be achieved by use of a higher antigen doses. Immunization per wound is possible with all kinds of wound, even with burns. Size of wound and wound-supply do not influence the efficacy of wound-immunization. Immunization per wound does not disturb wound healing. The experiments reported here showed, for the first time, that immunization per wound is as effective as parenteral immunization. The most important advantage of wound-immunization is the speed and ease with which it can be administered, a fact which predestines it for vaccination in emergency cases. In practice it will be useful to combine wound-vaccination with wound-sprays.

Administration, Topical↗
PubMed1975

[Experimental investigations on oral immunization with tetanus-toxoid (author's transl)].

Model-experiments in mice were used for the investigation of oral immunization with tetanus-toxoid. The efficacy of oral toxoid application was tested by challenge and anti-toxin determination. The oral immunization with tetanus-toxoid induced only a sufficient protection, when toxoid was in intensive contact with the mucous membranes of the oral cavity. Local immunization via gastro-intestinal-tract failed. After a single vaccination with 200 Lf tetanus-toxoid onto mucous membranes of the oral cavity the efficiency index was 75. In comparison, a single subcutaneous application of 2 Lf tetanus-toxoid resulted in an efficiency index of 100 and a single intranasal immunization of 100 Lf in an efficiency index of 93. So the application of toxoid subcutaneously or onto nasal mucous membranes induced higher protection than oral application. Temporary development of immunity after immunization via the mucous membranes of the oral cavity was much better than parenteral immunization. 20 per cent of orally immunized animals were immune 5 days p. vacc. At the same time subcutaneously immunized animals failed to develop any protection. The efficiency rates obtained in challenge correlate with antitoxin content in the serum.

Administration, Oral↗
PubMedDate not supplied

The role of multi-slice spiral CT angiography in patient management after endovascular therapy.

OBJECTIVES: To bring out the role of multi-slice spiral CT angiography (MS-CTA) in patient management after endovascular therapy of subclavian artery stenosis. METHODS: Twenty-one consecutive patients with clinically suspected restenosis after endovascular treatment of subclavian artery stenosis or occlusion were included in the study. Eleven patients had been treated with percutaneous transluminal angioplasty (PTA) alone and 10 with PTA and stenting. The mean follow-up period after PTA or stenting was 57 (+/-27 SD) months. CTA was performed using a bolus-triggered high-resolution protocol with biphasic intravenous contrast medium injection. Axial images and curved planar reformations (CPRs) were rated by three readers with regard to patency of supra-aortic vessels. Imaging findings were correlated with a standardized clinical assessment. RESULTS: All examinations were of diagnostic quality. Of 21 referred patients, 7 had significant reobstruction of the treated subclavian artery. Six of the 7 patients with significant restenosis on CTA were treated conservatively (antiplatelet agents), despite 2 of them being symptomatic on the standardized clinical assessment, which showed a sensitivity and specificity of 86% in predicting stenosis. One patient was treated with PTA and stent deployment because of strong subjective suffering. CONCLUSION: MS-CTA is useful for exclusion or quantification of clinically suspected restenosis in carefully selected patients after endovascular therapy where ultrasound is inconclusive and/or contrast-enhanced magnetic resonance angiography is contraindicated.

Angioplasty, Balloon↗