Careers of non-medical graduates in British medical research.
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Age Factors↗
Biomedical subjects
J Sadler
Publications and source records attributed to J Sadler.
Pharmacokinetics of bretylium in man after intravenous administration.
The pharmacokinetic profile of bretylium was studied in four normal male volunteers using a new sensitive EC-GC procedure for its quantitative in biological fluids. The plasma concentrations and urinary excretion rates following the constant i.v. infusion of a single 4 mg/kg dose of bretylium tosylate declined biexponentially and the data were fitted to a two-compartment model with a renal and a nonrenal route of elimination. The drug had a mean half-life (t1/2 beta) of 7.8 hr and apparent volume of distribution (Vd, beta) of 8.18 liters/kg. The renal clearance, which was 6 times that of the glomerular filtration rate, accounted for almost 84% of the total body clearance and correlated linearly with the subjects' creatinine clearance. The observed side effects of bretylium were mild and similar to those of other adrenergic blocking agents.
Adult↗
The use of basilic vein and brachial artery as an A-V fistula for long term hemodialysis.
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Adolescent↗
The effects of telomerase inhibitors on lymphocyte function.
BACKGROUND: Telomerase is an enzyme that is present in both cancerous cells and lymphocytes. Telomerase inhibitors block tumor cell growth and are being considered for chemotherapy. This study tested whether telomerase inhibitors suppress growth of leukemic cell lines and blood lymphocytes (PBMC). RESULTS: Reverse transcriptase inhibitors azidothymidine (AZT) and 3'-deoxy-2:3'-didehydrothymidine (d4T) decreased growth of all cells while dideoxyinosine (ddI) had no effect on Jurkat cells but increased growth of PBMC. The oligonucleotide (TTAGGG)3, which mimics the telomeric sequence, decreased growth of all cells. Inhibition by AZT, d4T and (TTAGGG)3 was manifested at 48-96 hours after addition to the cultures but not at 24 hours. The inhibition was partially to totally reversible upon inhibitor removal, indicating that the compounds were not cytotoxic but only suppressed cell growth temporarily. CONCLUSIONS: Immunosuppression may result from the use of telomerase inhibitors during chemotherapy but should only be temporary.
Cell Cycle↗