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Biomedical subjects

J S Scott

Publications and source records attributed to J S Scott.

At least 163 records · Page 9Linked to original sources
PubMed1983

Radiation nephritis in a case of a spindle cell neoplasm in remission after combination treatment with abdominal radiotherapy and chemotherapy.

A 34-year-old woman presented with acute radiation nephritis three months after completion of treatment with cytotoxic chemotherapy and abdominal radiotherapy. This case and similar previous reports suggest a potentiating effect by the chemotherapy of the renal damage by radiation which may cause radiation nephritis to develop at radiation doses normally within renal tolerance.

Abdominal Neoplasms↗
PubMed1980

Maternal estrogen excretion before perinatal death.

As the value of urinary estrogen measurement in prevention of perinatal death has been questioned, a series of 626 consecutive perinatal deaths was studied to identify possible failures of the technique. 101 deaths related to singleton pregnancies during which urinary estrogen excretion had been measured; 32 deaths were preceded by normal estrogen excretion but no antepartum death from chronic placental failure occurred in this group, whereas 28 of the 69 deaths preceded by abnormal excretion were attributed to this cause. Most of these deaths were for various reasons regarded as unavoidable. There was one death possibly due to induction of labor done because of abnormal estrogen excretion. 4 deaths following abnormal results might have been avoided by appropriate action. 13 deaths might have been prevented if the assays had been performed in cases in which indications were present. It is concluded that urinary estrogen excretion is abnormal before fetal death from chronic placental failure. Other techniques to detect risk of fetal death have not undergone such extensive validation.

Estrogens↗
PubMed1980

The utilization of an estrogen assay system in obstetric practice.

Subsequent to reviewing 626 perinatal deaths in relation to estrogen assay, 1500 consecutive pregnancies were analyzed in detail in regard to utilization of urinary estrogen assays. 2710 assays were performed on 456 cases. The perinatal mortality rate in this high-risk group was 8.8 per 1000 compared with the overall hospital rate of 15.1. Estrogen assays give efficient aid to pregnancy management economically; ways in which their contribution could be improved are suggested.

Cost-Benefit Analysis↗
PubMed1980

Pre-eclampsia and changed paternity.

A review of 34, 201 multigravid deliveries found 47 patients who had severe pre-eclampsia after previous normotensive, non-albuminuric pregnancies. In 13 of these patients the affected pregnancy was apparently by a new father compared with 3 matched controls (P less than 0.01). This evidence supports the idea of a paternal immunogenetic factor in pre-eclampsia; immunogenetics.

Adolescent↗
PubMed1980

Suppression of early rhesus sensitization by passive anti-D immunoglobulin: suppression of early rhesus sensitization.

Anti-D immunoglobulin is an effective prophylactic against rhesus isoimmunization. It is generally regarded as ineffective once antibody production has developed though there have been a number of inconclusive reports suggesting it may suppress early sensitization. Anti-D (100 micrograms) was given after delivery of a rhesus (D) positive child to a rhesus (D) negative mother who was shown to have anti-D antibodies at that time by five tests on two separate specimens in two different laboratories and by a weakly positive direct anti-globulin test on the cord blood. In a further pregnancy with a rhesus (D) positive child no antibody was detected by multiple tests including enzyme technique.

Adult↗
PubMed1980

Conservative management of pituitary prolactinomas; evidence for bromocriptine-induced regression.

Thirty-six women with sustained hyperprolactinaemia, 29 showing radiological abnormality of the pituitary fossa, were managed conservatively; 28 accepted bromocriptine treatment which controlled hyperprolactinaemia in all and was associated with improvement in the radiological appearance of the pituitary in 4 cases. Two of the 8 patients who did not accept bromocriptine showed radiological extension of the pituitary lesion; one showed radiological improvement. Bromocriptine should be regarded as a drug to control the pituitary tumour, not merely one which inhibits the endocrine effects.

Adult↗
PubMed1979

Congenital heart block and maternal systemic lupus erythematosus.

The association between infants with congenital heart block (CHB) and the presence or later development of maternal systemic lupus erythematosus or other connective-tissue disease (CTD) was reviewed in 67 cases. In 24 cases CHB was diagnosed at or before birth. Of nine necropsies on affected infants, seven showed endomyocardial fibrosis. The results suggest that one in three mothers who deliver babies with CHB have or will develop CTD. The association is probably explained by placental transfer of a maternal antibody. Awareness of the association may lead to prevention of the birth of children with CHB and better neonatal care of affected children.

Adolescent↗