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Biomedical subjects

J S Percy

Publications and source records attributed to J S Percy.

64 records · Page 4Linked to original sources
PubMedDate not supplied

In vivo and in vitro effects of gold salts on lymphocyte transformation responses and antibody dependent cell-mediated cytotoxicity.

In vivo, gold salts have been shown to induce disease remission in rheumatoid arthritis. In some patients, this is associated with a return to normal of suppressed lymphocyte responses to mitogens and antigens. This study demonstrates that gold salts will suppress lymphocyte transformation in vitro but do not affect antibody dependent cell-mediated cytotoxicity. This suppression appears to be dose-related. In contrast to previous studies, evidence is provided to suggest that the suppression of lymphocyte responses by gold may at least in part be due to a direct toxic effect of myochrisine on the cultured cells.

Antibody-Dependent Cell Cytotoxicity↗
PubMedDate not supplied

Gold therapy in rheumatoid arthritis. Interim report of the Canadian multicenter prospective trial comparing sodium aurothiomalate and auranofin.

One hundred and twelve patients with classical or definite rheumatoid arthritis (RA) were randomly assigned to receive either sodium aurothiomalate (GSTM) or auranofin (AF). Monthly clinical assessments (morning stiffness, grip strength, articular index, pain, quality of life) and concurrent hematological, biochemical, and urine studies were performed to monitor the efficacy/toxicity (E/T) ratio. Ninety-two patients have completed 3 months; 65, 6 months; 47, 9 months; and 30, 12 months. The groups were numerically balanced at each time period. Analysis of the 0-6 month period suggests that both drugs were equally and significantly beneficial after 3 months and that this was maintained at 6 months. Toxicity was as frequent in both groups but more serious in the GSTM group. The main side effects were gastrointestinal (diarrhea) in the AF group and mucocutaneous in the GSTM group. Half of the withdrawals (14 in each group) were because of side effects in the GSTM group and for inadequate therapeutic efficacy in the AF group. This study suggests that after 6 months of treatment the E/T ratio of AF is greater than or equal to that of GSTM. These conclusions will need to be confirmed during the ongoing longer observation period. A significant clinical difference between the 2 drugs is that in a given patient treated with GSTM, the onset of toxicity coincides with a good therapeutic effect. This relationship does not appear to exist during AF treatment.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Comparison between the surface electromyogram of the quadriceps surrounding the knees of healthy women and the knees of women with osteoarthrosis.

The purpose of this study was to compare the electromyographic (EMG) activity of the quadriceps femoris (QF) muscles of women with osteoarthrosis (OA) of the knee with the EMG activity of the QF muscles of healthy women. To this end, a total of 14 subjects attended a single test session during which full-wave rectified surface electromyograms were recorded from the rectus femoris (RF), vastus lateralis (VL) and vastus medialis (VM) muscles during maximum voluntary isometric quadriceps contractions performed at knee angles of 30 degrees and 60 degrees flexion. A comparison of the resultant normalized peak EMG ratios using independent t-tests demonstrated significantly higher composite QF muscle activation for the osteoarthrotic subjects (p < 0.05). A higher RF activation also differentiated the two groups. The findings raise the possibility of a direct correlation between abnormal activation of the QF and joint status. They also suggest that patients with knee OA may benefit functionally from rehabilitation designed to improve QF coordination and endurance, and not merely strength.

Adult↗