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Biomedical subjects

J S Lawson

Publications and source records attributed to J S Lawson.

At least 19 recordsLinked to original sources
PubMed1992

Lithium treatment: a comparison of once- and twice-daily dosing.

The effects of once- and twice-daily dosing with lithium carbonate were compared in a non-blind, cross-over study on 20 consecutive patients with mood disorders. Mental status, side effects and target organ function were examined after a minimum of a 1-month treatment with each regimen. Eighteen patients completed the study and 2 withdrew because of side effects. There were no significant differences between the 2 groups on the Hamilton Rating Scale for Depression, the Bech-Rafaelsen Mania Scale, the UKU Side Effects Scale or in serum lithium, electrocardiogram and urine volumes. Most blood tests showed no significant difference between the 2 treatment schedules except for white blood cells, ionized calcium and phosphate concentration. The once-daily regimen was associated with a higher white cell count, increased serum phosphate and elevated serum ionized calcium. We conclude that patients are able to tolerate once-daily dosing with lithium carbonate as well as twice-daily dosing.

Adolescent↗
PubMed1991

Recreating the village: the development of groups to improve social relationships among mothers of newborn infants in Australia.

There is a clear link between social relationships and health in terms of both morbidity and mortality. The study was conducted during 1989 and 1990 among mothers of newborn infants from a middle-ranking socioeconomic status suburb in Sydney (Ryde). Thirty-four per cent of the study group had a moderate level of social isolation and 16 per cent had a high level of social isolation. These mothers strongly valued participation in the groups: virtually all original participants remained with the group both during a five-week formal period with a nursing staff member as the leader and during months and up to five years of continued meetings. The outcomes appear to be favourable in terms of the development and continuation of strong interpersonal relationships among members of the group and by improved confidence and knowledge about infant rearing. The development of groups of mothers adds no cost to the provision of health services and provides a sound and practical way of reducing social isolation and increasing mothercraft skills in an Australian suburb.

Australia↗
PubMed1991

Decentralizing health services in Australia.

During the past 15 years the district health services in some parts of Australia have been reorganized, with the development of coordinated programmes that provide services across hospital and community boundaries as well as continuity of care over prolonged periods. Some financial resources have been redirected from institutions to community-based services. The process has been so successful that district reorganization has now been implemented throughout New South Wales (population, 5.5 million) and elsewhere in Australia.

Australia↗
PubMed1991

Health care for a thousand million.

Despite many difficulties and setbacks, China has made immense progress in health development during the past four decades. A continuing determination to reach all the people with preventive measures, primary care and hospital facilities should ensure that success is maintained in this field.

China↗
PubMed1990

Electrode placement in ECT: cognitive effects.

Forty patients suffering from a major depressive disorder, for whom electroconvulsive therapy (ECT) was clinically indicated, were assigned to one of three electrode placement groups: bitemporal (BT), right unilateral (RU) or bifrontal (BF). Comparisons of these groups in terms of cognitive status showed that the BF placement, which avoided both temporal regions, spared both verbal and nonverbal functions. These differential effects, which were independent of the degree of clinical depression, were not, however, evident three months after the last ECT.

Adult↗
PubMed1990

Prophylactic medication for unipolar depressive illness: the place of lithium carbonate in combination with antidepressant medication.

A meta-analysis of the controlled clinical trials comparing the efficacy of combined lithium-imipramine therapy with each drug alone in the prevention of relapse in patients with unipolar depressive illness shows the combination to be superior to lithium alone (for any relapse, p less than 0.05; for specifically depressive relapse, p less than 0.025) and imipramine alone (for any relapse, p less than 0.025; for specifically depressive relapse, p less than 0.05). The issue of statistical power in studies of this kind is discussed. A single case of unipolar depressive illness is described, in which combined lithium-tranylcypromine therapy was superior to either drug alone. A combination of lithium and an antidepressant should be considered for any patient suffering from this condition who fails to remain well on either drug alone.

Antidepressive Agents↗
PubMed1990

Vasopressin in chronic psychiatric patients with primary polydipsia.

Twelve chronic in-patients with primary polydipsia were studied, during free drinking and after fasting, by concurrent measurements of plasma AVP, serum sodium and osmolality, and urine volume, AVP, osmolality, and creatinine. A majority of the patients showed inappropriately high levels of AVP: plasma AVP estimations demonstrated that seven had Type I SIADH and two had Type II SIADH. Urinary AVP estimations confirmed inappropriately raised AVP in seven of the subjects tested, and there was a significant agreement between the plasma and urine diagnoses. Although able to concentrate their urine in response to fluid deprivation, the patients showed a decreased renal sensitivity to AVP. Despite the mitigating effect of decreased renal sensitivity to AVP, the SIADH seen in these patients appears to contribute to the development of water intoxication caused by polydipsia.

Adult↗
PubMed1989

Capillary gas chromatography of trihexyphenidyl, procyclidine and cycrimine in biological fluids.

A sensitive (50-100 pg/ml) method is described for the analysis of the anticholinergic drugs cycrimine, procyclidine and trihexyphenidyl by capillary gas chromatography with flame thermionic detection. Since these anticholinergic drugs are frequently administered in combination with antipsychotic medication for the treatment of mental illness, the potential interference by antipsychotic drugs in this assay was examined. No interference was observed from a series of antipsychotic drugs in the quantitation of cycrimine, procyclidine or trihexyphenidyl. The use of this technique to study trihexyphenidyl pharmacokinetics in man is described.

Antipsychotic Agents↗
PubMed1989

Learning disability in adults: a comparison of two indices of differential cognitive impairment derived from the Wechsler scales.

Two indices descriptive of patterns of differential cognitive impairment have been derived from principal component analyses of the normative data of the Wechsler scales for adults (WAIS-R) and children (WISC-R), respectively. The former index is sensitive to the test-specific cognitive effects of unilateral cerebral damage in adults. The latter accurately describes the pattern of subtest scores produced by learning-disabled children. The present study reviews the available WAIS and WAIS-R data from adults with learning disability in order to determine which of these two indices more precisely delineates their pattern of test performance; the index derived from the children's test appears to be the one best able to do so.

Adult↗
PubMed1989

Osteopenia, pathological fractures, and increased urinary calcium excretion in schizophrenic patients with polydipsia.

Ten male chronic schizophrenic patients with polydipsia and 10 nonpolydipsic controls, matched for gender, diagnosis, duration of illness, age, and race, were studied by dual- and single-photon absorptiometry to estimate bone density of the lumbar spine and radius and by 24-hr urine collections to estimate urinary electrolyte excretion. Bone density was normal in the control group, but was abnormally low in the polydipsic group, which had a markedly increased incidence of fractures. Electrolyte excretion was normal in the control group and in the polydipsic group when water intake was restricted to normal amounts; increased urinary sodium and calcium excretion occurred in proportion to polydipsia. As polydipsia is associated with a number of physiological changes, the cause of the osteopenia is unclear; we suggest that a negative calcium balance caused by increased urinary calcium excretion induced by extracellular space expansion may play an important role in the causation of the skeletal changes.

Adult↗
PubMed1989

Day care: can it prevent readmission to a psychiatric hospital?

This report concerns the readmission rate for patients involved in Day Care programs at Kingston Psychiatric Hospital. Readmissions were counted for a 3 year period, and results compared with groups of patients who did not attend Day Care. Seventy-three percent of the Day Care Group were readmitted within 3 years as compared to 45% of the main Control Group; however, the Day Care Group had the lowest mean number of readmissions, 1.08, as compared to the Control Group, with 1.25. The relative merits of these two ways of measuring admission rates is discussed in relation to the search for valid outcome criteria. The results were interpreted to indicate that Day Care and related support services help ensure that readmission only occurs in the event of a serious exacerbation of the psychiatric state.

Adult↗
PubMed1986

Environmental control systems in chronic care hospitals and nursing homes.

Fifteen severely disabled people residing in institutions were provided with a simple environmental control system which performed five different functions. The disabled people used the equipment an average of ten times a day. Two hours of nursing care by nursing staff would have been required to perform these functions. The cost of the equipment was $1.35 a day. Both the residents and the nursing staff reacted favorably to this innovation. The main benefits which resulted were a heightened sense of independence on the part of the disabled people and a reduction of frustration levels of both the residents and the nursing staff. A considerable savings in nursing care was also achieved.

Attitude↗
PubMed1979

Optimum dosage of an oral contraceptive. A report from the study of seven combinations of norgestimate and ethinyl estradiol.

A statistically designed study was carried out to determine an optimum combination of norgestimate and ethinyl estradiol as an oral contraceptive, based on efficacy, safety, and side-effect patterns. A total of 1,991 patients were studied for more than two years while they were receiving various dosage combinations of these steroids. There were seven dosage combinations studied as part of a statistically orthogonal experimental design, augmented by three combinations near the center. The data arising from these studies were used to fit approximate functions relating the amount of norgestimate and ethinyl estradiol to the rate of spotting and breakthrough bleeding, gastrointestinal disturbance, and pregnancies. These functions, in turn, helped to identify an optimum dosage (0.125 mg. of norgestimate plus 0.035 mg. of ethinyl estradiol) in the entire range of combinations studied.

Adolescent↗
PubMed1979

Glass laceration injuries and prevention.

Accidents involving glass in doors, sidelights, specially vulnerable windows, and shower screens are an important cause of injury, and occasionally death. Most of the injuries are superficial cuts and abrasions, but many involve deep lacerations of tendons, nerves and muscles. The accidents occur mainly in children and young adults with the highest rate being among males aged from 15 to 19 years. The number and severity of these injuries could be reduced through the wider use of appropriate forms of safety glazing: laminated glass or toughened glass in new installlations, and the application of a plastic safety film to existing glass.

Adolescent↗