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Biomedical subjects

J S Kuipers

Publications and source records attributed to J S Kuipers.

15 recordsLinked to original sources
PubMed1981

A comparison of cefamandole, cefoxitin, cefuroxime, cefotaxime and cefoperazone: an in vitro test on a number of beta-lactamase producing strains of 9 species and 1 genus of bacteria.

The sensitivity of a number of beta-lactamase producing strains of Enterobacter aerogenes, Enterobacter cloacae, Enterobacter species, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa and Serratia marcescens to cefamandole, cefoxitin, cefuroxime, cefotaxime and cefoperazone was determined in vitro. All bacterial cultures were examined for beta-lactamase production using the chromogenic cephalosporin compound 87/312. All strains were typed by means of antibiotic and chemotherapeutic sensitivities. Only non-identical strains were used. A tray method was used to determine the quantity of antimicrobial product necessary for a complete growth inhibition at various culture dilutions. The results showed that all strains of H. influenzae, especially in the dilution 2.10(6), were sensitive to the five cephalosporins. The other species and genus of bacteria had a varying sensitivity to the five cephalosporins. Cefoperazone had potent activity against Ps. aeruginosa. Differences between the five cephalosporins with regard to the effect of culture dilution were only small.

Bacteria↗
PubMed1979

A comparison of the in vitro activities of sulfamethoxazole and sulfadiazine combinations with trimethoprim.

The sensitivity of 125 strains of 13 species or genera of bacteria to sulfamethoxazole (SMZ), sulfadiazine (SDZ), trimethoprim (TMP), SMZ + TMP and SDZ + TMP was determined by means of trays. A comparison of all combinations of the different concentrations used shows that SMZ + TMP is in 1 case and SDZ + TMP in 4 cases more effective against the 13 species or genera tested than the other combinations. SMZ and SDZ were equally effective in synergistic action (as shown by the FIC indices) against the various kinds of bacteria.

Bacteria↗
PubMed1976

Combinations of antimicrobial agents: II. The in vitro sensitivity of 52 strains of proteus species to sulphafurazole, polymyxins and combinations of sulphafurazole and polymyxins.

The sensitivity of 52 strains of Proteus species to sulphafurazole, polymyxins and the combinations of sulphafurazole and polymyxins was determined by means of discs and trays. It was found that 2 and 6 strains, respectively, were sensitive to discs containing 100 mug sulphafurazole and 300 mug polymyxin B, respectively, 41 strains were sensitive to the combination of discs containing 100 mug sulphafurazole and 50 mug colistin, respectively, and 38 strains were sensitive to the combination of discs containing 100 mug sulphafurazole and 300 mug polymyxin B, respectively. The tray method proved that 2 and 5 strains were sensitive to 25 and 200 mug sulphafurazole, respectively, and that 1, 2 and 3 strains were sensitive to 25, 50 and 100 mug polymyxin B, respectively. Also 41 strains were sensitive to the combination of 100 mug sulphafurazole and 25 mug colistin and 38 strains were sensitive to the combination of 25 mug sulphafurazole and 6.3 mug polymyxin B. There was good agreement between the results of the disc and of the tray studies. The synergism between sulphonamides and polymyxins may offer therapeutic possibilities.

Drug Synergism↗
PubMed1976

Combinations of antimicrobial agents. III. The in vitro sensitivity of 12 strains of Pseudomonas aeruginosa and 12 strains of proteus species ot sulphamethoxazole + trimethoprim (co-trimoxazole), polymyxins and combinations of co-trimoxazole and polymyxins.

The sensitivity of 12 strains of Pseudomonas aeruginosa and of 12 strains of Proteus species to co-trimoxazole, polymyxins and combinations of co-trimoxazole and polymyxins was determined by disc and tray methods. It was found that all strains were sensitive to the combinations of co-trimoxazole and polymyxins. The disc study of the strains of Ps. aeruginosa revealed a typical image with many strains. The tray study gave a typical image with two strains of Proteus species. The two images are briefly discussed. The synergistic action of co-trimoxazole and polymyxins may well offer therapeutic possibilities.

Drug Combinations↗
PubMed1975

Combinations of antimicrobial agents. I. The in vitro sensitivity of 100 strains of Pseudomonas aeruginosa to polymyxin B, colistin, carbenicillin, gentamicin and doxycycline and to various combinations of these antibiotics.

The MICs for 100 strains of Pseudomonas aeruginosa were determined for polymyxin B, colistin, carbenicillin, gentamicin and doxycycline and various combinations of these antibiotics. This study was carried out by means of a tube dilution method. Additive actions were observed in the combinations of polymyxin B plus carbenicillin, polymyxin B plus gentamicin, polymyxin B plus doxycycline, carbenicillin plus doxycycline and gentamicin plus doxycycline. A synergistic action was observed for the combinations of colistin plus carbenicillin, colistin plus gentamicin, colistin plus doxycycline and carbenicillin plus gentamicin. In none of the combinations was any antagonistic action encountered. Numerous reasons for using combined antibiotic treatment are listed. The results were obtained exclusively in in vitro investigations.

Carbenicillin↗
PubMed1970

Bactericidal properties of Tego 103 S and Tego 103 G.

The bactericidal activity of Tego 103S was compared with that of chlorhexidine in ethanol, and Tego 103G with Halamid. The activity was determined on Pseudomonas aeruginosa, Staphylococcus aureus and Achromobacter anitratus by various methods. Tego 103S in 1% solution was less active than chlorhexidine 0.5% in 70% ethanol, and Tego 103G in 1% solution was less active than Halamid 0.3%. The presence of serum did not noticeably influence the activity of the Tego preparations.

Alcaligenes↗