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Biomedical subjects

J S Han

Publications and source records attributed to J S Han.

At least 343 records · Page 19Linked to original sources
PubMed1984

Dynorphin: potent analgesic effect in spinal cord of the rat.

Evidences are presented to show a strong and long-lasting analgesic effect after injection of dynorphin into the subarachnoid space of the spinal cord in the rat. Taking the amplitude and time course of the increase of tail flick latency as the indices of analgesia, dynorphin elicited dose-dependent analgesic effect in the range of 2.3-18.6 nmol. Calculating on a molar basis dynorphin was 6-10 times more potent than morphine and 65-100 times more potent than morphiceptin, another mu opiate receptor agonist. Dynorphin analgesia was completely reversed by intrathecal injection of anti-dynorphin IgG and partially reversed by naloxone. Acute tolerance to morphine analgesia did not affect the occurrence of dynorphin analgesia, indicating the absence of cross tolerance between morphine and dynorphin. Evidence from different lines of approach suggests that dynorphin may bind with kappa opiate receptors in the spinal cord to exert its analgesic effect.

Analgesia↗
PubMed1984

Magnetic resonance imaging in the spinal column and craniovertebral junction.

The sensitivity of magnetic resonance imaging (MRI) to tissue alterations is particularly useful in spinal cord imaging. In addition to excellent anatomic display of this compact and complex area, syrinx cavities, tumors, and degenerating disks can be identified before they cause the anatomic distortion often necessary for detection by conventional means.

Astrocytoma↗
PubMed1983

Intracranial metastatic Wilms' tumor in children: a report of two cases.

Two cases are presented of children with intracranial metastasis from Wilms' tumor. Both patients had undergone nephrectomies for Wilms' tumor, one 19 months and the other 32 months prior to clinical presentation of intracranial metastasis. Computed tomographic examination in both cases demonstrated lesions that did not have any particularly unique features. Subsequent craniotomy and removal of the tumor in one case confirmed metastatic intracranial Wilms' tumor.

Brain Neoplasms↗
PubMed1983

Primary amyloid tumor of the lacrimal gland: CT findings.

We present a rare case of primary amyloid tumor originating in the lacrimal gland. The computed tomographic findings are similar to those of an orbital angioma, showing an enhancing soft tissue mass with multiple calcifications simulating phleboliths.

Amyloidosis↗
PubMed1983

NMR imaging of the spine.

The usefulness of nuclear magnetic resonance (NMR) images in the evaluation of spinal disorders below the craniocervical junction was studied. Six normal subjects and 41 patients with various spinal abnormalities were examined. NMR proved capable of demonstrating important normal and pathologic anatomic structures; it was useful in the evaluation of syringohydromyelia and cystic spinal cord tumors, and the bright signal intensity of lipoma was quite impressive. In the evaluation of herniated disk, NMR images offered a new perspective by visualizing abnormal degradation of the signal intensity of the nucleus pulposus itself. NMR images were least valuable in the evaluation of spondylosis and spinal stenosis. Although NMR imaging of the spine is still in a very early developmental stage, the absence of both ionizing radiation and risks associated with contrast material makes it especially attractive as a new diagnostic method. This limited experience with currently available equipment suggests that, with technical refinement, the efficacy of NMR of the spine will increase.

Adolescent↗
PubMed1983

Electroacupuncture analgesia blocked by microinjection of anti-beta-endorphin antiserum into periaqueductal gray of the rabbit.

The possible role of beta-endorphin (beta-EP) in mediating the analgesic effect elicited by electroacupuncture (EA) was assessed by injecting antiserum against beta-EP into the periaqueductal gray (PAG) of the rabbit. Two antisera (HO and UA) were raised in rabbits against human beta-EP, each of which recognized human, porcine, bovine, ovine, camel and rat beta-EP, the only difference being that HO recognized rabbit beta-EP while UA did not. The effect of EA analgesia was found to be seriously attenuated by injecting HO into PAG of the rabbit, while UA was ineffective. The results indicated a PAG pool of beta-EP as an important component in mediating EA analgesia.

Acupuncture Therapy↗
PubMed1982

Computed tomographic observations pertinent to intracranial venous thrombotic and occlusive disease in childhood. State of the art, some new data, and hypotheses.

Selected topics are discussed and new observations recorded regarding computed tomographic (CT) evaluation of intracranial venous thrombotic and occlusive disease in childhood. High density of the vein of Galen and adjacent venous sinuses (relative to brain) can be seen normally in children. A number of potential pitfalls in the diagnosis of superior sagittal sinus thrombosis are also disclosed. A case of cavernous sinus thrombosis with abnormal CT changes in included. In addition, the normal CT appearance of the cavernous sinus is described. In some cases, filling defects occur which appear to correlate with normal cranial nerves. An unusual case of venous sinus occlusion by neoplasm (sarcoma) is presented. Finally, new findings in the Sturge-Weber syndrome are analyzed. Enhancement of the brain in this condition may have its basis in altered circulation resulting from fundamental venous abnormalities.

Adolescent↗