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Biomedical subjects

J S Haller

Publications and source records attributed to J S Haller.

At least 55 records · Page 3Linked to original sources

"The artful science:" medicine's self-image in the 1890's.

Carried on the coattails of the century's scientific and technological revolution, Anglo-American medicine acquired a self-image and sense of purpose that belied its fragile roots. The growth of the laboratory, the popularity of the inductive method, the beginnings of government and private support for medical education, the envy of the German university experience and the new-found importance of medical societies fell in easy step with Victorian pride and the national imperative. America's medical education system grew at a slower pace, inhibited by a laissez-faire bias which reinforced the weaker aspects of its egalitarian society. The fabric for America's medical reform lay in the European clinical experience of its better educated physicians, and the transference of their enthusiasm and reform zeal into the university and medical society environment. By the 1890s, the artful science of medicine had combined the benefits of a century's scientific endeavors with the age-old instinct for useful application.

History, 19th Century↗

The value of neuroradiology in infantile spasms.

The results of neuroradiologic studies of 71 children with infantile spasms treated with ACTH were correlated with the developmental outcome at follow-up (mean 62 months, range 14 to 207 months). Fifty-two (73%) patients had an abnormal NRS on initial evaluation; 49% had cerebral atrophy, 18% had congenital anomalies, and 6% had hydrocephalus. Twenty patients were normal on initial clinical evaluation. At follow-up only the eight (40%) with normal NRS were normal. Twelve (60%) who had unexpected abnormalities on NRS were retarded at follow-up. CAT scanning is necessary to predict the developmental outcome in developmentally normal children with infantile spasm. Eight of nine patients with normal NRS in the early treatment group were developmentally normal at presentation and follow-up. Ten patients who were developmentally normal before spasms began, and had normal NRS but were in the late treatment group, were retarded at initial evaluation and follow-up. This finding suggests that early treatment of children who have a normal NRS and normal development at onset of spasm prevents mental retardation.

Adrenocorticotropic Hormone↗

The effect of ACTH therapy upon infantile spasms.

Fifty-five infants with infantile spasms and hypsarrhythmia, who were treated with ACTH using 80 units im every other day for a mean period of ten months, were studied retrospectively and showed better results than infants using so-called nonsteroidal anticonvulsants or ACTH and steroids in other doses and with other time intervals. The study showed that the treatment with ACTH within the first month of onset of spasms produced a higher incidence of spasm-free state while on treatment, a shorter duration of spasms while on treatment, and a higher incidence of spasm-free state while on treatment, a shorter duration of spasms while on treatment, and a higher incidence of a spasm-free state when off treatment, compared to a similar regimen of ACTH begun after seizures had persusted for more than a month. The value of early treatment of infantile spasms suggests that the treatment of this disease should be regarded as a medical emergency.

Adrenocorticotropic Hormone↗