Wegener's granulomatosis presenting as ophthalmoplegia and optic neuropathy.
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Adult↗
Biomedical subjects
J S Greene
Publications and source records attributed to J S Greene.
Effect of irradiation on guinea pig ABR thresholds.
A significant number of patients undergo irradiation to the temporal bone for malignancies. Conflicting reports exist regarding the effects of irradiation on hearing thresholds. Although radiation-induced otitis media and osteoradionecrosis of the ossicles with resultant conductive hearing loss are well-documented, there is disagreement regarding the effect of irradiation on sensorineural hearing. Previous animal models, relying only on behavioral tests and reflex thresholds, have failed to reveal consistent threshold shifts after irradiation. However, with the advent of auditory brainstem response (ABR) testing, a reliable objective measurement of hearing in animals is available. Hearing thresholds were determined bilaterally by ABR testing in 21 albino guinea pigs. The left temporal bones of sixteen animals were then irradiated with a total dose ranging from 5750 to 7000 cGy over 7 weeks. The right ears of these animals, plus both ears of five nonirradiated guinea pigs, served as controls. Follow-up threshold ABRs were obtained immediately post-irradiation (RT), and at 6 and 12 months post-RT. Average thresholds in all groups increased over time: 60 dB in the control group; 53 dB in the control ears of the irradiated animals; and 46 dB in the irradiated ears. There were no statistically significant increases in ABR thresholds for irradiated ears vs. control ears. At the 6-month followup, hearing was actually better in the irradiated ears than the control ears and this difference between ears was significantly greater than the difference at baseline (p < 0.026). Overall, there was no evidence that irradiation produces changes in ABR thresholds.
Animals↗
Signal-averaged electrocardiography: a new technique for determining which patients may be at risk for sudden cardiac death.
Signal-averaged electrocardiography is a useful diagnostic tool and screening test for those patients at risk for the development of VT. It is also useful in the evaluation of the patient after MI and the patient with unexplained syncope. The prognostic value of the signal-averaged ECG process is gaining popularity. More investigation is needed, especially in the areas of technique and significance of abnormalities, before the signal-averaged ECG becomes a routine test in diagnosing dysrhythmias. The signal-averaged ECG provides the health care team with a new, non-invasive test. Knowledge of its use and application can provide the clinician with additional information that can aid in the screening process for patients at risk for sudden cardiac death.
Death, Sudden↗
Corneal injuries.
The article on corneal injuries illustrates the means by which mechanical, chemical, and radiant energies interrupt the normal anatomy and physiology of the cornea. Methods of diagnosis and management of such problems, including those caused by contact lenses, are presented.
Burns, Chemical↗
Absence of a tachycardic response to intraperitoneal hemorrhage.
Five cases of intraperitoneal hemorrhage associated with hypotension and the lack of a tachycardic response are presented. All patients were young, previously healthy women without a history of myocardial disease. None of our patients fits into the category of "irreversible shock." Although relative bradycardia associated with hypotension is often considered a preterminal event, each of our patients recovered after laparotomy. In hypovolemic shock due to intraperitoneal bleeding, the lack of a tachycardic response may occur earlier and perhaps more often than has been suggested, and may delay definitive treatment by confusing the clinical picture. Orthostatic vital signs may be helpful in distinguishing those with true hypovolemia.
Adult↗
Retropharyngeal abscess: a previously unreported symptom.
Four cases of retropharyngeal abscess are presented. All patients were older than the usual age group and all complained of pain in the back of the neck or shoulder precipitated or aggravated by swallowing. All recovered. The clinical features of retropharyngeal abscess are discussed, and the possible importance of this previously undescribed symptom in distinguishing retropharyngeal abscess from other less serious disease entities is proposed.
Abscess↗