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Biomedical subjects

J S Fox

Publications and source records attributed to J S Fox.

8 recordsLinked to original sources
PubMed1991

Cardiovascular effects of cromakalim (BRL 34915) in healthy volunteers.

1. The effect of oral doses of cromakalim 0.5, 1.0, 1.5 and 2.0 mg on several cardiovascular parameters was studied in healthy male volunteers. 2. In the first study, no dose of cromakalim reduced systolic or diastolic blood pressure in the supine or standing position. Reductions of diastolic blood pressure after exercise (P less than 0.01) were observed 4 h after administration of 2.0 mg. 3. There was a trend towards increased heart rate after 2.0 mg at all time intervals, and significant changes were observed in supine and standing heart rate at 2 and 4 h (P less than 0.01). No significant change was observed in exercise heart rate. 4. In the second study small increases in forearm blood flow were observed from 3 h to 5 h after oral administration of 1.0 and 2.0 mg of cromakalim. Forearm vascular resistance was significantly reduced after 2.0 mg (P less than 0.025) when compared with placebo. No change was observed in forearm venous capacitance after either dose of cromakalim, or placebo. Supine heart rate was significantly increased 4 h after 2.0 mg of cromakalim (P less than 0.025). 5. These results show that oral administration of cromakalim decreases diastolic blood pressure and forearm vascular resistance. A hypotensive effect is probably attenuated by reflex tachycardia.

Administration, Oral↗
PubMed1989

Vaginal myxoma presenting as acute urinary retention.

Vaginal myxoma is an extremely rare tumor. We report a case in which the initial complaint was acute urinary retention. The tumor had grown quite rapidly over a 4-month period. It was resected easily and did not recur over the next 5 years.

Acute Disease↗
PubMed1986

Pseudoobstruction of the colon.

A previously unreported complication of extraperitoneal node dissection, pseudoobstruction of the colon, is described as a case report, and its etiology and treatment are discussed.

Adult↗
PubMed1985

Assessment of delayed-type hypersensitivity in man: a comparison of the "Multitest" and conventional intradermal injection of six antigens.

Recall of delayed type hypersensitivity (DTH) as a test for cell-mediated immune competence was assessed in 254 subjects using the Multitest device which delivers seven skin-test antigens intradermally; 77 subjects were tested concurrently by Multitest and a conventional panel of six antigens. Similar results were obtained with Multitest and the conventional panel (R = 0.65). Reproducibility of Multitest between three observers, who independently assessed the aggregate size of reactions (the reaction score) in 45 subjects, was high (R = 0.89). Twenty-four subjects were tested twice 3 months apart; the correlation for the reaction score was high (R = 0.88), demonstrating the suitability of Multitest for serial studies of immune function. Anergy was infrequent (1%) among 110 healthy male controls but was more frequent (8%) among a group of 101 healthy male homosexuals (P less than 0.05). The response rate to particular test antigens differed for the three Australian groups tested and a previously studied French group. Hence there is a need to establish normal profiles of DTH responsiveness for different geographic areas, as well as among subjects of known age and sex, when assessing cell-mediated immunity by the level of DTH responsiveness to multiple skin test antigens.

Adolescent↗
PubMed1979

Episiotomy.

Explore the source record for details and available documents.

Episiotomy↗
PubMed1976

Computed tomography in the diagnosis of pseudotumor cerebri.

The authors reviewed 17 patients with the clinical diagnosis of benign intracranial hypertension (pseudomotor cerebri). All of these patients underwent CT scans of the head which were interpreted as normal. Comparison of mean ventricular size with that of a group of control subjects showed no significant difference. On the basis of this study and others cited, there would appear to be almost no instances in which invasive neuroradiological procedures would be required to confirm the diagnosis of pseudotumor cerebri.

Adolescent↗
PubMedDate not supplied

Computer-assisted measurement of peripheral blood flow.

An automated system for the measurement of peripheral blood flow using venous occlusion plethysmography based on the low-cost Apple II microcomputer, together with purpose-built compressor unit and data acquisition interface, has been developed. The computer performs the dual role of controlling the timing of inflation and deflation of the occluding cuffs and recording the resulting increase in limb circumference. Ten 8 s epochs of data are acquired and analysed per session. Flow rate is computed using a least squares fit between 0.5 and 4.0 s after cuff inflation, giving on-line indication of blood flow. Venous capacitance and digital systolic pressure may be measured using additional algorithms. The system has been used for the investigation of circulatory disorders and in the assessment of drugs acting on the peripheral circulation.

Blood Pressure↗