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Biomedical subjects

J S Finch

Publications and source records attributed to J S Finch.

33 records · Page 2Linked to original sources
PubMed1981

Use of PEEP in acute respiratory distress syndrome in dogs.

This study evaluates the effectiveness of combining mechanical ventilation and 5 cm H2O positive end-expiratory pressure (PEEP) at the onset of adult respiratory distress syndrome (ARDS) in dogs. Five cm H2O PEEP applied at the onset of ARDS in oleic acid injured dogs resulted in a decrease in cardiac output (CO). This decrease was accompanied by beneficial effects including a relatively stable SaO2 and PaO2. Control group dogs (receiving mechanical ventilation only) showed a less dramatic changing in CO, but demonstrated a dramatic drop in saturation, compromising oxygen transport of the tissues. Thus, despite decrease in CO experienced by the PEEP group, oxygen extraction at the tissue level remained high.

Animals↗
PubMedDate not supplied

Clinical investigation of the analgesic potency and respiratory depressant activity of fentanyl, a new narcotic analgesic.

A controlled clinical comparison of fentanyl and morphine in 75 postsurgical patients is presented. In addition, the ability of the two drugs to produce respiratory depression was determined in six healthy volunteers. The results of these studies indicate that 0.2 mg. fentanyl intramuscularly is equianalgesic with 10 mg. morphine intramuscularly, and it would appear that there is no advantage in the use of fentanyl for the relief of postsurgical pain.

Adult↗
PubMedDate not supplied

Analgesic comparison of propiram fumarate with pentazocine, codeine, and placebo in postsurgical pain.

The safety and effectiveness of a single oral dose of 50 mg propiram fumarate as an analgesic was compared in a double-blind clinical trial trial against single doses of standard reference analgesics (50 mg pentazocine hydrochloride or 60 mg codeine sulfate) or placebo. Subjects were adult patients experiencing severe postsurgical pain. Mean pain scores and SPID scores showed all three active drugs to be favored (P less than 0.05) over placebo in patients with severe initial pain. The most common side effects seen were drowsiness, nausea, and dizziness. These were not severe enough to require treatment. Propiram fumarate (50 mg) was shown to be an effective and safe analgesic in the treatment of severe postsurgical pain.

Adolescent↗