Long-term audiovisual scalp EEG monitoring is an essential diagnostic tool for the evaluation of paroxysmal disorders. The definitive classification of both nonepileptic and epileptic events is often possible only with the use of this technique. Assessment of response to treatment and the noninvasive presurgical localization of seizure foci are other important uses. The optimization of both clinical semiology and electrophysiologic data obtained from such studies is the subject of significant research efforts. Outcomes studies and advanced EEG analysis research should ultimately serve to minimize the cost of this valuable technique as well as maximizing its utility.

Adult↗

PubMed1999

EEG source modeling. The first word.

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Action Potentials↗

PubMed1999

EEG source modeling. The last word.

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Electroencephalography↗

PubMed1999

Intracranial EEG in temporal lobe epilepsy.

Intracranial EEG monitoring before epilepsy surgery, while becoming less commonly performed in patients with unilateral mesial temporal lobe epilepsy, is still widely used when bilateral independent temporal lobe seizures are suspected or when extratemporal foci cannot be ruled out by noninvasive means. Additionally, many epilepsy centers are reporting excellent surgical outcome in patients with neocortical temporal lobe epilepsy, when resections are guided by intracranial EEG studies. This article reviews the indications, technical aspects, risks, and interpretation of intracranial EEG in patients with temporal lobe seizures. It also considers intracranial EEG features predictive of surgical outcome.

Brain↗

PubMed1999

Intracranial EEG. The last word.

Explore the source record for details and available documents.

Brain↗

PubMed1999

Visual and quantitative ictal EEG predictors of outcome after temporal lobectomy.

PURPOSE: We investigated whether visual and quantitative ictal EEG analysis could predict surgical outcome after anteromesial temporal lobectomy (AMTL) in which mesial structures, basal, and temporal tip cortex were resected. METHODS: We retrospectively reviewed 282 presurgical scalp-recorded ictal EEGs (21- to 27-channel) from 75 patients who underwent AMTL. We examined the pattern of seizure onset (frequency, distribution, and evolution) and estimated the principal underlying cerebral generators by using a multiple fixed dipole model that decomposes temporal lobe activity into four sublobar sources (Focus 1.1). We correlated findings with a 2-year postoperative outcome. RESULTS: Sixteen patients had seizures with a well-lateralized, regular 5 to 9-Hz rhythm at onset, that most often had a temporal or subtemporal distribution. All patients became seizure free after surgery. In 51 patients, seizure onset was remarkable for lateralized slow rhythms (<5 Hz), which sometimes appeared as periodic discharges, were often irregular and stable only for short periods (<5 s), and had a widespread lateral temporal distribution. Among these a favorable surgical outcome was encountered in patients with seizures having prominent anterior-tip sources ( 16 of 17 seizure free), whereas those with dominant lateral or oblique sources had a less favorable outcome (three of 14 and 13 of 18, respectively). Irregular, nonlateralized slowing characterized seizure onsets in eight patients. Three patients became seizure free after surgery. CONCLUSIONS: Both visual and quantitative sublobar source analysis of scalp ictal EEG can predict surgical outcome in most cases after AMTL and complement non-invasive presurgical evaluation.

Electrodes, Implanted↗

PubMed1999