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J S Collins

Publications and source records attributed to J S Collins.

77 records · Page 5Linked to original sources
PubMedDate not supplied

Eradication of Helicobacter pylori: the results of a pilot study of 3, 5 & 7 day triple antibiotic regime with bismuth for one month.

In a prospective study designed to assess the effect of duration of antibiotic therapy on the helicobactericidal and ulcer healing efficacy of bismuth therapy, groups of patients, 10 in each group, with H. pylori-positive duodenal ulcer received a triple therapy regimen consisting of colloidal bismuth subcitrate 120 mg 4 times daily for 28 days with metronidazole 400 mg 3 times daily and tetracycline 500 mg 3 times daily for the first 3, 5 or 7 days of therapy. H. pylori infection was assessed by urease test, culture and histology performed before and 4 or more weeks after completion of therapy. Three patients (30 per cent) were H. pylori-negative after therapy in the 3 day compared with 5 (50 per cent) in the 5 day and 9 (90 per cent) in the 7 day treatment groups (3 vs 7, P = 0.01; 5 vs 7, P = 0.14). Healed ulcers were seen in 7 (70 per cent) of the 3 day, in 6 (60 per cent) of the 5 day, and in 10 (100 per cent) of the 7 day treatment groups (5 vs 7, P = 0.04). Bismuth triple therapy incorporating metronidazole and tetracycline for 7 days is associated with superior H. pylori eradication and ulcer healing rates than bismuth triple incorporating antibiotics for 3 or 5 days.

Adult↗
PubMedDate not supplied

Long-term semi-quantitative follow-up of Helicobacter pylori associated gastritis.

Helicobacter pylori infection has been implicated with the development of gastric carcinoma and lymphoma. We studied the long-term effects of H. pylori infection on gastric mucosa. Ten patients with Helicobacter pylori infection underwent repeat endoscopy and antral biopsies 8 years later. Gastric mucosal features (polymorphs, monocytes, intestinal metaplasia, atrophy and lymphoid aggregates) were graded from mild to severe (0 to 3) based on the Sydney system of gastritis classification. At repeat biopsy, 1 patient was negative for H. pylori after eradication therapy. Two patients (20 per cent) had spontaneous disappearance of H. pylori. One of these had intestinal metaplasia which progressed to low grade dysplasia. Polymorphs decreased with eradication of H. pylori (P < 0.05). Lymphoid aggregates increased with continued H. pylori infection but decreased with eradication of H. pylori (P < 0.05). Monocytes, intestinal metaplasia and atrophy remained unchanged. Persistent H. pylori infection appears to increase lymphoid aggregates and may promote its evolution into gastric lymphoma while eradication of H. pylori may result in a reduction of polymorphs and lymphoid aggregates.

Adult↗
PubMedDate not supplied

The role of TNF and its receptors in Alzheimer's disease.

Tumor necrosis factor (TNF) is an important proinflammatory cytokine that is upregulated in Alzheimer disease (AD) patients and involved with AD genes. Several TNF promoter polymorphisms that increase expression are associated with inflammatory and infectious diseases. We previously reported results that detected a AD associated region near the TNF gene. Using family-based association tests we also reported an association between AD and a TNF haplotype in sibling-pair families, and a significant increase in the mean age of onset for a group of African-American AD patients carrying this same haplotype. Previous reports have shown that that the chromosome 1p and chromosome 12p regions are linked to late-onset AD. These two regions harbor TNF receptors (TNFR) 2 and 1, respectively, and binding to them mediates biological effects of TNF. We found a significant asssociation of a TNFR2 exon 6 polymorphism with late-onset AD in families with no individuals possessing the APOE E4E4 genotype under a dominant model. We found no significant association of three polymorphisms in the TNFR1 gene to AD. These results provide further evidence for the involvement of TNF in the pathogenesis of AD.

Alzheimer Disease↗
PubMedDate not supplied

Fat suppression in combination with multiple overlapping thin-slab 3-D acquisition MR angiography: proposed technique for improved vessel visualization.

PURPOSE: To study the parameters of the 1331 fat saturation pulse (saturation pulse flip angle (SPFA) and interpulse delay (tau)) in order to identify values that provide optimal vessel visibility. METHODS: Carotid bifurcations of three healthy subjects were studied. RESULTS: The optimal values for the SPFA and tau were 60 degrees (7.5 degrees, -22.5 degrees, 22.5 degrees, -7.5 degrees) and 2.0-3.0 msec, respectively. At these values there was a 1.56-fold increase (SD = +/- .12, P less than .01) in the contrast-to-noise ratio between the left internal carotid artery and fat compared to the study without fat saturation. A 3.0-fold increase was noted for the smaller left occipital artery. Additionally, there was no statistically significant reduction in the vessel-muscle contrast-to-noise ratio nor in the absolute vessel signal-to-noise ratio at these values. CONCLUSION: Implementation of fat saturation into carotid MR angiography markedly improves visualization of vascular anatomy without increasing imaging time.

Adipose Tissue↗