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Biomedical subjects

J S Barkin

Publications and source records attributed to J S Barkin.

At least 145 records · Page 8Linked to original sources
PubMed1981

Therapeutic percutaneous aspiration of pancreatic pseudocysts.

The therapeutic efficacy and safety of percutaneous aspiration of chronic pancreatic pseudocysts was evaluated. Eight patients underwent aspiration a total of ten times. Permanent resolution was obtained in two patients and a third nonsurgical candidate was offered an alternative therapeutic modality. This procedure is simple, rapid, and safe and could become the initial approach to selected patients with a chronic pancreatic pseudocyst.

Adult↗
PubMed1981

The safety of combined endoscopy, biopsy and dilation in esophageal strictures.

The evaluation and management of esophageal strictures ordinarily involves the three procedures of endoscopy, biopsy, and dilation at different times. The safety of performing these procedures in a single sitting was evaluated. The study included 48 patients (ages 44-85) with radiographically confirmed esophageal strictures located in the upper third (3/48), middle third (18/48), and lower third (27/48) of the esophagus. The strictures were determined to be due to peptic esophagitis of varying severity (28/48) or carcinoma (20/48). Dilation immediately followed endoscopy and biopsy with an average of three mercury-weighted dilators passed at this sitting. The size and type of dilators were determined clinically by the endoscopic estimation of esophageal lumen diameter. Anesthesia included topical Cetacaine and intravenous diazepam (5-15 mg.). All patients experienced symptomatic improvement immediately following the procedures. No complications were encountered. These data indicate that endoscopy, biopsy and dilation of esophageal strictures may safely be performed in a single sitting. Other advantages may include shortened hospital stay, earlier diagnosis and relief of symptoms and increased cost effectiveness.

Adult↗
PubMed1980

Endoscopic therapy of the "sump" syndrome.

Choledochoduodenostomy may be followed by the "sump syndrome." This previously required surgical intervention. We describe the successful application of endoscopic therapy in two patients with this syndrome.

Cholangitis↗
PubMed1980

Choriocarcinoma of the stomach.

A 23-year old woman with primary choriocarcinoma of the stomach presented with abdominal pain and massive hepatomegaly. Serum levels of CEA and serum and urine levels of beta-HCG were markedly elevated. Immunoperoxidase staining for CEA and HCG reveal both to be present in morphologically typical carcinoma cells. This suggests that serum beta-HCG may be a useful tumor marker of gastric carcinoma.

Adult↗
PubMed1979

Significance of a dilated pancreatic duct on CT examination.

The infrequency of reports demonstrating dilatation of the pancreatic ducts in patients with chronic pancreatitis by CT, despite its frequent demonstration on endoscopic retrograde cholangiopancreatography (ERCP), prompted a review of 500 cases performed at the University of Miami School of Medicine/Jackson Memorial Hospital for suspected pancreatic disease. Pancreatic duct dilatation was demonstrated in 10 patients. An equal occurrence was documented in patients with chronic pancreatitis and with carcinoma. Therefore, the presence of dilated pancreatic duct only confirms the presence of pancreatic disease. No etiology should be favored by the isolated finding of a dilated duct on CT scanning.

Chronic Disease↗
PubMed1979

Radiation therapy of a pancreatic fistula.

A patient with a pancreatic cutaneous fistula subsequent to laparotomy was unresponsive to medical management including intravenous hyperalimentation. Radiation therapy resulted in progressive diminution of volume from the fistula with subsequent complete closure. Radiation thus offers another therapeutic modality for pancreatic fistulas.

Female↗
PubMed1978

Circulating carcinoembryonic antigen in pancreatic carcinoma.

Circulating CEA levels were determined in 102 patients wtih histologically proven pancreatic carcinoma and 26 patients with chronic pancreatitis. In the group with pancreatic carcinoma eleven patients had resectable tumors, the mean CEA in the nonjaundiced patients was 10 +/- 5 ng/ml while the mean value in jaundiced patients in this group was 27 +/- 40. Thirty-four patients with nonmetastatic locally unresectable disease had a mean serum CEA of 25 +/- 52 with a range of 1 to 250 ng/ml. Twenty-one percent had values of 5 ng/ml or less. The mean value in 57 patients with metastatic disease was 97 +/- 194 with a range of 0.05 to 1000 ng/ml and 19 percent had values of 5 ng/ml or less. Survival of patients with locally unresectable or metastatic carcinoma was significantly longer in those patients who had a normal CEA at the time of diagnosis. Circulating CEA in the metastatic group was much lower in patients with nonhepatic metastases as well as in those with well differentiated adenocarcinoma histology. Twenty-three patients with chronic pancreatitis and normal serum bilirubin had a mean CEA value of 5.3 +/- 4 ng/ml with 65% of values being 5 ng/ml or less but the CEA ranged from 4.6 to 27 in three who were jaundiced.

Adenocarcinoma↗
PubMed1978

Initial levels of CEA and their rate of change in pancreatic carcinoma following surgery chemotherapy and radiation therapy.

CEA levels and their rate of change in 41 patients with pancreatic carcinoma following surgery, chemotherapy and radiation therapy were determined. Surgical resection, though not curative, was associated with a decrease in CEA level, with approximately half these levels returned to normal. No correlation with survival was noted. CEA levels are increased by obstructive jaundice. Radiation alone or in combination with 5-Fluorouracil did not change CEA levels in patients with locally unresectable pancreatic carcinoma. CEA levels progressively increased in patients with widespread metastatic pancreatic carcinoma, who expired from their disease.

Alkaline Phosphatase↗
PubMed1978

Fluoroscopically guided thin needle aspiration biopsy of the abdomen and retroperitoneum.

The results of 49 transabdominal and translumbar thin needle percutaneous aspiration biopsies in patients suspected of having malignant disease are reported. A correct diagnosis was obtained in 40 cases. Placement of the Chiba needle was accomplished by fluoroscopically controlled biplane radiography during constrast examinations. No complications were encountered. The technique allows cytologic diagnosis of malignancy without high risk exploratory surgery, prolonged hospitalization, or delay of treatment. Use of fluoroscopic needle guidance and biplane radiography for confirmation of position using various contrast examinations as markers is felt to be superior to either CT or ultrasound. The technique is readily available in all radiology departments.

Abdominal Neoplasms↗
PubMed1978

Cancer of the colon as a late sequel of pelvic irradiation.

A patient, who developed carcinoma of the rectum nine years following therapeutic radiation for pelvic malignancy is presented. The relationship of radiation to carcinoma of the colon is reviewed. This relationship makes rigorous follow-up of patients with radiation induced chronic proctocolitis essential.

Carcinoma↗