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Biomedical subjects

J Rybakowski

Publications and source records attributed to J Rybakowski.

At least 127 records · Page 7Linked to original sources
PubMedDate not supplied

The effects of lithium treatment on cation transport processes in erythrocytes of patients with affective illnesses.

The effect of lithium administration on cation transport processes in erythrocytes was investigated in 26 patients with affective illnesses. The measures of ouabain-dependent sodium and potassium transport, Na+K+ATP-ase activity and lithium-sodium countertransport in erythrocytes were taken before and after 14 days of lithium therapy. In eleven patients an additional assay was made, following 3-12 months of continuous lithium administration. A significant increase in sodium and potassium transport as well as Na+K+ATP-ase activity was found after 14 days of lithium therapy, while the intensity of lithium-sodium countertransport markedly decreased. Maintenance treatment with lithium tended to stabilize these changes on the altered level. A role of cation transport in the mechanism of lithium action is discussed. It is suggested that an increment of erythrocyte active cation transport may accompany the normothymic effect of lithium.

Adolescent↗
PubMedDate not supplied

Cation fluxes in erythrocytes of patients with endogenous depression in the course of treatment with antidepressant drugs.

Erythrocyte cation fluxes were measured in 30 patients with endogenous depression, before and after 14 days of treatment with antidepressant drugs, imipramine or nomifensine. Assays were made of active (ouabain-sensitive) transport of sodium and potassium as well as of lithium-sodium countertransport, reflecting sodium exchange diffusion. All the parameters studied increased significantly on 14th day of the thymoleptic treatment. The mean increase in activity of cation fluxes was similar in patients receiving imipramine or nomifensine. Patients with good clinical response to the treatment (as rated by the reduction of the initial intensity of depression on the Hamilton Scale on 21st day of therapy) had greater increase in ouabain-sensitive sodium flux than "non-responders". A possible role of cation transport processes in the mechanism of action of antidepressant drugs is discussed.

Adult↗
PubMedDate not supplied

Ouabain-sensitive sodium and potassium fluxes in red blood cells of patients with endogenous depressive syndromes.

Ouabain-sensitive cation fluxes in red blood cells were measured in 23 patients with endogenous depressive syndromes during acute phase of the illness and during remission period as well as in 17 healthy subjects. The intensities of both sodium and potassium net fluxes during depressive phase were significantly lower than during remission both in patients with depression in the course of manic-depressive psychosis and in patients with unipolar depression. They were also lower than the intensities of fluxes found in control subjects. The values of female patients in remission did not differ from those of control females, while male patients had higher values in remission than control males. It is hypothesized that impaired activity of cation transport may be related to somatic and psychopathologic symptoms of depression and its stimulation may play a role in the mechanism of action of antidepressant drugs.

Adult↗