Biomedical subjects
Publications and source records attributed to J Rubenstein.
We report a case of fracture of the ulnar sesamoid of the metacarpophalangeal joint of the thumb. The role of arthrography and stress X-rays in delineating the pathological anatomy of this injury is discussed.
The presence of tibio-talar slant is reported in an adult patient with Down syndrome. No previous description of this deformity in connection with Down syndrome has been found.
Fifty-nine patients with end-stage renal disease undergoing long-term dialysis were studied prospectively for joint disease. Radiographic assessment allowed division of patients into 3 groups: group 1 included 12 patients with renal osteodystrophy and erosions of the metacarpophalangeal, proximal interphalangeal, distal interphalangeal, shoulder, wrist, and knee joints; group 2 had 11 patients with renal osteodystrophy without articular erosions; group 3 included 36 patients without osteodystrophy or erosions. Clinical manifestations were frequent in patients of group 1 and included episodes of arthralgias of the metacarpophalangeal, wrist, proximal interphalangeal, and knee joints. Patients of groups 1 and 2, particularly those of group 1, had a longer mean duration of dialysis and a higher mean serum alkaline phosphatase level compared with group 3 patients. The study indicates that there is a relatively high incidence (20%) of erosive arthropathy in dialysis patients. Renal osteodystrophy, more specifically, secondary hyperparathyroidism, and duration of dialysis are important factors in the development of this articular disorder.
The knees of 11 volunteers were examined by magnetic resonance (MR) imaging. The imaging was done with a 0.15 T resistive magnet using spin-echo pulse sequences. Normal anatomy was well displayed. The visualized structures included the menisci, cruciate ligaments, articular cartilage, cortical and cancellous bone, muscles, tendons, subcutaneous and intraarticular fat, and blood vessels. To obtain optimal visualization of the anterior cruciate ligaments, various positionings of the subjects and angulation of the imaging planes were tried. Rotation of the sagittal scanning plane away from the longitudinal axis of the body was found to be most satisfactory. The results obtained so far are very promising and demonstrate the real potential of MR imaging in the knee, which we believe lies in its ability to visualize the menisci and cruciate ligaments without use of contrast agents.
One hundred fifty war veterans with ankylosing spondylitis were entered into a prospective study in 1947. In 1957, 142 were traced, and they have been reviewed periodically. Eighty-one of these patients were still alive in 1980. Information was obtained from 67 (83%) of the survivors and 51 were reexamined. This report is based on the clinical findings in these 51 patients, who have a mean disease duration of 38 years. Forty-seven (92%) were functioning well. The disease in 21 (41%) had progressed to cause severe spinal restriction. Of those, 12 had peripheral joint involvement early in their course and 9 had iritis. Seventy-four percent of the patients who had mild spinal restriction after 10 years did not progress to having more severe restriction. Eighty-one percent of the patients who had severe spinal restriction in 1980 were severely restricted within the first 10 years. Hips that were normal after 10 years of disease did not become diseased subsequently. This study suggests that a predictable pattern of ankylosing spondylitis emerges within the first 10 years of the disease.
Cross-sectional cuts through the acetabulum of a cadaveric pelvis were obtained to evaluate the bony anatomy. There are six slices of 1 cm thickness which define the acetabulum. This information has been important to us primarily to assess acetabular fractures with computerized tomography.
Twenty-four patients have been evaluated to demonstrate the role of computerized tomography (CT) in assessment of acetabular fractures. CT is important in defining the articular dome, intraarticular and femoral head abnormalities, associated sacroiliac damage and soft-tissue injury. The CT examination can be obtained with minimal additional discomfort to the patient.
Cross-sectional cuts through the acetabulum of a cadaveric pelvis were obtained to evaluate the bony anatomy. There are six slices of 1 cm thickness which define the acetabulum. This information has been important to us primarily to assess acetabular fractures with computerized tomography.
Twenty-four patients have been evaluated to demonstrate the role of computerized tomography (CT) in assessment of acetabular fractures. CT is important in defining the articular dome, intraarticular and femoral head abnormalities, associated sacroiliac damage and soft-tissue injury. The CT examination can be obtained with minimal additional discomfort to the patient.
Explore the source record for details and available documents.
The therapeutic advantages and liabilities that accrue to the indigenous therapist (be he professional or paraprofessional) because of the indigenous state were explored, utilizing the five-year experience of ten indigenous therapists in Boston's North End. The current and historical proximity of therapists who live in the same neighborhood as their patients do provides both with increased access to, longitudinal knowledge about, and a blurred role concept of the other that may help or hinder the therapeutic process. Similarities in culture and values can foster alliance formation, differentiation of psychopathology, and therapeutic interventions, but also may interfere when therapy abuts culturally shared blind spots. These data are relevant to the private general psychiatrist as an indigenous therapist in non-metropolitan America.
Explore the source record for details and available documents.
The C1300 murine neuroblastoma system has been studied to determine its relevance as a chemotherapy model to the human disease. Studies using combination therapy revealed that BCNU/cyclophosphamide combination therapy increased the median lifespan 300% in A/J mice bearing the C1300 tumor. Cyclophosphamide/imidazole carboxamide and adriamycin/imidazole carboxamide combinations were less active, increasing median lifespans 189% and 144%, respectively. Vincristine/bleomycin were inactive even when the schedule was adjusted to coincide with the time of maximum mitoses following vincristine injections. These results suggest the BCNU/cyclophosphamide combination chemotherapy may be effective in human disease.
Concordance of differential visual and manipulative responsiveness to novel stimuli at 6 months of age was found when differential attractiveness and familiarity of the stimuli were controlled. This finding corroborates the findings of an earlier study in which the same object was used as the familiarization object for all subjects. The data indicate that concordance at 6 months of age is not an artifact of the test procedure. A hypothesis suggested by the comparison of these findings with others in the literature is that the opportunity to manipulate a wide variety of objects in the natural environment may contribute to the concordance of visual and manipulative responsiveness to novel stimuli at this age.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.