The HLA antigens appear to be involved in the rejection of corneal allografts. A relationship exist between HLA compatibility and the corneal rejection-free transplant survival. Eleven corneal transplants are performed on the basis of the best available HLA A and B match. Rejection-free transplant in this group is compared to a control group. The estimate rejection-free survival is 82%.

Corneal Diseases↗

PubMedDate not supplied

[HLA antigen expression of human cornea. Effect of organ culture preservation].

The aim of this study is to examine the variation of HLA expression on organ-cultured human corneas. Using an indirect immunofluorescence technique and monoclonal antibodies anti-HLA-A, B, C and anti-HLA-DR histocompatibility antigens were detected. In fresh corneas class I antigens were detected on epithelium and stroma but not on endothelium. Class II antigens were not detected on any corneal layer but were present on Langerhans cells within epithelium and stroma. The expression of HLA-A, B, C antigens within the corneal epithelium and the corneal stroma was not altered by 28 days of organ culture. HLA-DR antigens were present on Langerhans cells on corneas that had been in organ culture up to 14 days (present 6/9). After 14-28 days in culture Langerhans cells were not found on most corneas (present 3/12). Corneal preservation in organ culture at 31 degrees C affects expression of HLA antigens particularly of HLA-DR antigens. Combination of HLA matching donor-recipient with an 10-15 days organ cultured corneal button in high-risk patients seems to be of interest.

Cornea↗

PubMedDate not supplied

[The Binder syndrome and goniodysgenesis. Apropos of a case].

A 15 years old boy was deferred to our department with growth hormone deficiency, deafness with middle ear bones involvement, and a facial dysmorphy called Binder syndrome. He presented ocular abnormalities with juvenile glaucoma and iris anterior insertion and goniodysgenesis. All these pathologic features are linked with the development of the neural crests. In our knowledge, it is the first so complete clinical association reported, which emphasizes the important role of the neural crest cells in early organogenesis.

Abnormalities, Multiple↗

PubMedDate not supplied

[Ciprofloxacin: intraocular absorption in man].

The intraocular penetration of Ciprofloxacin in man: authors have studied the penetration of Ciprofloxacin in the aqueous humor of 30 patients (30 eyes). The concentration in the anterior chamber was on average 0.73 mg/l which is 33% of serum level, from 1.30 hours after a single oral dose of 1000 mg till the 4th hour after this dose. The samples were assessed by a microbiological method. These results are over the minimal inhibitory concentration for many bacterial agents found in endophthalmitis. So this antibiotic may be proposed in the treatment of endophthalmitis. Anyway further investigation is mandatory to assess the safety on efficacy of these antibiotics.

Administration, Oral↗

PubMedDate not supplied

[Keratomycoses: practical aspects].

In our daily clinical practice, keratomycosis still remain a challenge for both the ophthalmologist and the laboratory. In this paper simple advices are listed to help us, especially in the topical medical treatment. The emerging role of silver sulfadiazine is pointed out.

Antifungal Agents↗