Search PubMed⌕ Search

Biomedical subjects

J Rovira

Publications and source records attributed to J Rovira.

At least 55 records · Page 3Linked to original sources
PubMed1992

[Economic evaluation of prophylaxis with recombinant granulopoiesis stimulating factor].

BACKGROUND: The aim of the study was to economically evaluate the prophylactic use of the recombinant factor of the stimulation of granulocyte colonies (rG-CSF) for the prevention of episodes of febrile neutropenia (EFN) following antineoplasic chemotherapy. METHODS: The methods of economic evaluation used were those of cost analysis and cost-effectivity analysis. The probability of occurence of EFN was estimated by the application of the Delphi method and the costs were calculated. RESULTS: The costs of EFN for the patients with solid tumors is situated between 236,000-377,000 pesetas according to hospitalary centers. For patients with acute leukemia the value was estimated as between 391,000-667,000 pesetas. The results of the cost analysis indicate that the net cost per patient prophylactically treated is between 4,000-64,000 pesetas. The results of the cost-effectivity analysis indicate that the cost per case of no incidence of EFN is between 20,000-320,000 pesetas. CONCLUSIONS: Episodes of febrile neutropenia carry expansive hospital and antibiotic clinical treatment. The prophylactic use of new medication for patients between the first and second cycle of chemotherapy, in agreement with the estimates calculated, does not save health care costs but may improve the quality of life in these patients and permit the continuation of a therapeutic schedule without interruption which may improve the life expectancy of the patient.

Antineoplastic Agents↗
PubMed1992

[Role of the amniotic fluid in gastroschisis. An experimental study].

The short and thick bowel found in gastroschisis has been attributed to contact with amniotic fluid, among other factors. We designed an original animal model in order to isolate the effect of amniotic fluid on the fetal bowel. We created experimental gastroschisis in fetal rabbits. Extruded bowel was kept out of the amniotic sac in half of the operated fetuses. At term, seven days after surgery, 21 surviving fetuses--12 intra-amniotic (GIA) and nine extra-amniotic (GEA)--and 16 control littermates were harvested for study. Five parameters were measured in each animal: body weight, intestinal weight, intestinal length, bowel diameter and bowel wall thickness. We found no statistically significant difference in body weight, intestinal weight or bowel wall thickness. An enormous difference was found in intestinal length among the three groups. Bowel diameter was significantly different in the extreme groups (GIA and controls), with the intestine being more dilated in GIA than in GEA and controls. Gastroschisis in the absence of amniotic fluid has not been as damaging to the fetal intestine as "natural" intraamniotic gastroschisis.

Abdominal Muscles↗
PubMed1991

[Otological assessment in patients operated on for cleft palate].

Tympanometry and otoscopy has been carried out to determine the presence of middle ear disease on patients with cleft palate and the influence of corrective surgery. This explorations have been evaluated preoperatively and at one and six months postoperative follow-up. There is a high incidence of otitis media with effusion in patients with cleft palate, almost 60 per 100 in our study. The influence of cleft palate surgery repair has not revealed as a mayor factor on its resolution, although a visible benefit has been observed in the long term controls. We recommend a otorhinolaryngological follow-up in these patients.

Acoustic Impedance Tests↗
PubMed1989

Adrenocortical tumors in childhood: a report of four cases.

In the last 10 years, four children with adrenocortical tumors were treated in our hospital. Three of them had symptoms of adrenogenital virilizing syndrome, and another, nonfunctional, was found during a routine examination. A diagnosis of adrenocortical tumor was established given the symptoms, hormonal tests, and radiologic studies. Two of the tumors were located in the left side, and the histologic diagnosis was pleomorphic cortical adenoma; the ones that affected the right side were adenocarcinomas. All the patients were treated by surgery and none received chemotherapy. At both presurgical and postsurgical stages, the patients were treated with cortisol. All four children have had a favorable course, with normal growth and the disappearance of public hair and hirsutism; however, macrogenitals still persist.

Adenoma↗
PubMed1989

Agenesis of the trachea.

We report a case of agenesis of the trachea type III of Floyd that survived for 2 days with an esophageal intubation. Surgical treatment consisted of a distal esophageal binding, cervical esophagostomy in double-barrelled shotgun, and gastrostomy. Death occurred on the third day after surgery.

Esophagostomy↗
PubMed1989

Segmental dilatation of the duodenum.

In this article two cases of idiopathic duodenal dilation are described. These cases meet the present criteria for segmental dilations of the intestine. The onset of the clinical features was acute in one case and chronic in the other. However, the radiological images were similar in both cases and provided the diagnosis. Surgical treatment consisted of duodenal resection and tapering and was curative in one case. The other patient died shortly after surgery. The duodenal specimens showed normal three-layer duodenal architecture in the pathology study. The intramural nervous plexi were unimpaired. Angiodysplasia was found in one case. Vascular abnormalities were also found in 10 other segmentary intestinal dilatations reported in the literature. The surgical implications of this new localization of segmentary intestinal dilatation are analyzed.

Dilatation, Pathologic↗
PubMed1989

Treatment of an enteric fistula with somatostatin in a premature.

The authors present the case of an extremely premature baby affected by severe Necrotizing Enterocolitis (NEC) needing intestinal resection and ileostomy. An enteric fistula developed 3 days after ostomy closure. The baby was started on Total Parenteral Nutrition (TPN), and 7 days later the fistula output remained constant. Somatostatin (SM) was then given intravenously (3.0 micrograms/Kg/hr) and the fistula closed on the 3rd day of treatment. Since SM was introduced in 1986 as an adjunct treatment to TPN in enteric fistulas, the authors believe that theirs is the first report of a successful SM treatment in a premature.

Enterocolitis, Pseudomembranous↗
PubMed1989

[Usefulness and indications for Port-a-Cath in children with acute leukemia].

Duration of treatment for acute leukemia is as long as 2 years. During this time, venous punctures are repeated every few days. The Port-a-Cath system allows a long-lasting but intermittent venous access. Since March 1987, 11 Port-a-Cath systems have been implanted in 11 children (age 3 to 14) with the diagnosis of high risk acute leukemia (9 ALL and 2 AML). The facial vein has been used in five instances, the external jugular vein in five, and the jugular vein in one case. Ten systems have had a good function. Seven are still in use, and the duration ranges from 450 to 47 days. Two children died because of their disease, their catheters still functioning. Two systems have been withdrawn, one for incorrected location and the other for cutaneous necrosis of the puncture site. Two more children developed reversible thrombosis. The Port-a-Cath system is useful in children affected by high risk acute leukemia, ameliorating their life quality and avoiding the need for repeated vein punctures.

Acute Disease↗
PubMed1988

Iatrogenic arteriovenous fistula in infancy.

Iatrogenic arteriovenous fistulas (AVF) in infancy are rare and are usually located at the level of femoral and antecubital vessels. They are generally secondary to multiple diagnostic or therapeutic arterial or venous punctures. The diagnosis is usually easy to make on clinical grounds; however, invasive procedures such as digital subtraction angiography (DSA) can be used to locate the fistula. These iatrogenic AVF may present as direct vascular communications or pseudoaneurysms originating in the venous wall. Surgical treatment is the therapy of choice. The case of an infant with an iatrogenic AVF of the femoral vessels is presented.

Arteriovenous Fistula↗
PubMed1985

Paraneoplasic precocious puberty. Report of a new case with hepatoblastoma and review of the literature.

A new case of precocious puberty secondary to production of human chorionic gonadotropin (HCG) by an hepatoblastoma was studied in an 8-month-old infant. A review was made of the 35 cases of paraneoplasic precocious puberty previously reported in the literature. The most frequent cause is hepatoblastoma, which was responsible for 18 cases. There are nine reports of mediastinal teratoma, six of which were observed in patients with Klinefelter Syndrome. In another six cases, the paraneoplasic syndrome was attributed to intracranial tumoration, and two of these patients showed teratoma with areas of choriocarcinoma, whereas germinoma was suspected for clinical reasons in another three. Lastly, one case of presacral teratoma and one of retroperitoneal carcinoma were reported. The differential characteristics of paraneoplasic precocious puberty are: almost exclusive occurrence in males, because of tumoral production of HCG, moderate or absent increase of testicle size, hyperplasia of Leydig's cells without spermatogenesis, and rapidly progressive signs of puberty.

Carcinoma, Hepatocellular↗
PubMed1983

Intraspinal migration of a rectal foreign body.

This is a description of a rare case of intraspinal foreign body, a clinical thermometer bulb, which after perforating the rectum migrated through the second left sacral foramina and sacral canal up to the epidural space at S1-L5 level. A first attempt to remove it by laparotomy while it was still in the retrorectal space proved unsuccessful. Retrieval was finally achieved by laminectomy.

Child, Preschool↗
PubMed1983

[Study of biliary tract atresia with HIDA Tc 99].

This report has been motivated to assess the permeability of portoenterostomy with isotopic methods (HIDA Tc 99) in two cases of biliary tract atresia. Both cases have followed a good evolution during 1 1/2 and 8 years respectively, with vanishing of the icterus and achieving an acceptable biliary flow. We used the hepatic gammagraphy with HIDA Tc 99 to evaluate biliary drainage and functional status of biliary tract. Also we used other classical biochemical parameters. This isotope is useful to evaluate the effectiveness of portoenterostomy by the amount and quality of biliary flow, and specially drainage ducts. Actually this method is the safest as compared to all the others, specially transparietohepatic cholangiography. The special characteristics os this isotope and the quality of the records allow the study of both function and structure of hepatic parenchyma through the curves activity/time. This curve measures between the periphery of hepatogram and porta hepatis follows a parallel course to bilirubin clearance. By all that we think that this method, with serial determinations, can be a precise parameter of surgical intervention, and it is useful as a early indicator of bad course, allowing an evaluation of cholangitis and the indication to reintervention.

Bile Ducts↗