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Biomedical subjects

J Roujeau

Publications and source records attributed to J Roujeau.

At least 19 recordsLinked to original sources

[Mortality due to tuberculosis. Statistical concepts].

The mortality statistics due to tuberculosis drawn up by INSERM for the years 1968-1973 show the rate to be 0.86% in the Paris region. A study based on autopsy results of 7,400 adults gave a rate of 3.3%. The causes of this discrepancy are analysed.

Age Factors

[Diaphyseal bone tuberculosis].

The authors report a case of diaphyseal bony tuberculosis, in which the diagnosis was not made for a long time as bony tuberculosis is considered exceptional and owing to the presence of a staphylococcus which oriented the diagnosis towards osteomyelitis. Bony tuberculosis certainly affects more easily immigrant patients, in whom one may see multifocal forms, but also affects those who, by their environment, might imagine they are protected, and it is not exceptional to see unifocal forms.

Femur

[The necropsy, contribution to the knowledge of the undesirable effects of medications and toxic agents].

All the examples quoted demonstrate that in the field of toxicology, pathologic anatomy still offers the means of establishing the first links between macroscopic and microscopic lestions and physiology. The current trend in this disciplin is to look beyond the clinical symptom or morphologic disturbance and seek the causal biochemical interactions. Through the methods of systematic autopsy and electron microscopy of biopsy specimens, pathologic anatomy continues to provide the alarm signal for the pharmacologic warning system our modern environment demands.

Autopsy

[Results of concentrated irridiation in glioblastomas, astrocytomas and brain tumours of the adult (author's transl)].

Concentrated irradiation (two series of 1,800 rads in 2 sessions and 3 days) separated by a rest period of 3 to 4 weeks has been used to treat 214 adult patients with brain tumors between 1965 and 1972. These included 108 glioblastomas, 18 astrocytomas and 88 brain metastases from different origins. Early side effects are moderate or inexistent provided synthetic ACTH or corticoid steroids have been given several days before irradiation. Survival is related, at least, in the first 2 groups of primary tumor to local failure. For brain metastases, death could be related to others reasons. In spite of the fact that comparison is made with a previous series of 121 cases it seems that this type of irradiation gives the same survival rates. Moreover it has specific advantages as reducing duration of hospitalization and the number of treatment sessions.

Adult