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Biomedical subjects

J Roth

Publications and source records attributed to J Roth.

At least 811 records · Page 45Linked to original sources
PubMed1974

Isolation of P22 specialized transducing phage followong F'-episome fusion.

A P22 specialized transducing phage has been constructed which carries the structural gene for aspartate transcarbamylase (ATCase). This gene (pyrB) was first brought close to the P22 attachment site by fusing an F' pyrB(+) episome to an F' prolac episome which carries a P22 prophage attachment site. A prophage was added to these fused F' episomes and the lysogen was UV-induced. The specialized transducing phage was isolated from the resulting lysate. The phage also carries argI, the structure gene for ornithine transcarbamylase.

Aspartate Carbamoyltransferase↗
PubMed1973

"Big" growth hormone components from human plasma: decreased reactivity demonstrated by radioreceptor assay.

Plasma as well as pituitary immunoreactive human growth hormone (HGH) comprises at least two discrete components which have been designated as "big" HGH and "little" HGH. Using a newly developed radioreceptor assay, which depends on the ability of a substance to compete with labeled HGH for binding sites on cultured human lymphocytes, we find that the big HGH component from both normal and acromegalic subjects has much less activity in the radioreceptor assay than in the radioimmunoassay, whereas the little HGH component has simnilar activity in both assays.

Acromegaly↗