General proteolytic activity of highly purified preparations of clostridial collagenase.
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Animals↗
Biomedical subjects
J Rosenbloom
Publications and source records attributed to J Rosenbloom.
Conformation of underhydroxylated collagen synthesized by 3T6 fibroblasts in culture.
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Anaerobiosis↗
Hydroxyproline stabilizes the triple helix of chick tendon collagen.
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Animals↗
Micropreparative equilibrium density centrifugation in the analytical centrifuge.
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Carbon Isotopes↗
Hydroxyproline content determines the denaturation temperature of chick tendon collagen.
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Amino Acids↗
Evidence that chick tendon procollagen must be denatured to serve as substrate for proline hydroxylase.
The ability of chick-embryo proline hydroxylase to hydroxylate [(14)C]proline-labelled procollagen was investigated between 23 degrees and 37 degrees C. The amount of hydroxy[(14)C]proline that could be formed increased sharply between 26 degrees and 30 degrees C. This corresponded to the temperature interval in which the [(14)C]procollagen substrate was thermally denatured, and the results therefore indicate that only denatured molecules can be hydroxylated.
Animals↗
Biosynthesis of collagen in the periodontal ligament.
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Carbon Radioisotopes↗
Metabolism by isolated fibroblasts of abnormal collagens containing analogues of proline or lysine.
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Animals↗
Identification of a soluble intermediate during synthesis of elastin by embryonic chick aortae.
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Journal Article↗
Effects of incorporation of trans-4,5-dehydrolysine on collagen biosynthesis and extrusion in embryonic chick tibiae.
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Alanine↗
Lag between incorporation of proline into protocollagen and synthesis of hydroxyproline during collagen biosynthesis in vitro and in vivo.
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Animals↗
Inhibition of proline and lysine hydroxylation prevents normal extrusion of collagen by 3T6 fibroblasts in culture.
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Journal Article↗
Incorporation of cis-hydroxyproline into protocollagen and collagen. Collagen containing cis-hydroxyproline in place of proline and trans-hydroxyproline is not extruded at a normal rate.
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Alanine↗
Trans-hydroxyproline is not incorporated into collagen.
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Animals↗
Incorporation of 3,4-dehydroproline into protocollagen and collagen. Limited hydroxylation of proline and lysine in the same polypeptide.
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Amino Acids↗
Sequential steps in the synthesis of hydroxylysine and the glycosylation of hydroxylysine during the biosynthesis of collagen.
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Amino Acids↗
Biosynthesis of abnormal collagens with amino acid analogues. II. Inability of cartilage cells to extrude collagen polypeptides containing L-azetidine-2-carboxylic acid or cis-4-fluoro-L-proline.
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Amino Acids↗
Low-tryptophan diet in treatment of psoriasis.
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Adolescent↗