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Biomedical subjects

J Rosborg

Publications and source records attributed to J Rosborg.

17 recordsLinked to original sources
PubMed2006

Family cluster of cholesteatoma.

OBJECTIVE: We report an extremely rare case of family clustering of cholesteatoma. METHOD: Case reports and a review of the world literature concerning cholesteatoma and heredity are presented. RESULTS: The family consists of parents and seven siblings of whom the mother and three sons have been surgically treated for cholesteatoma. All cholesteatomas in the family are acquired and all have a history of otitis media. Cholesteatomas occur with an incidence of 5/100,000 in Greenland, corresponding to two to three new cholesteatoma patients per year among the 57,000 inhabitants of Greenland. The family is very exceptional and interesting for further research concerning heredity in the pathogenesis of acquired cholesteatoma. CONCLUSION: To our knowledge this is the first report in the world literature of family clustering of acquired cholesteatoma. This case indicates that hereditary factors interplay with other factors in the pathogenesis of cholesteatoma.

Adolescent↗
PubMed1997

Necrotizing external otitis: aminoglycoside and beta-lactam antibiotic treatment combined with surgical treatment.

Necrotizing external otitis is a life-threatening condition that still causes therapeutic problems. A retrospective analysis of 22 patients who were all treated with a short standard course of aminoglycoside and beta-lactam antibiotic with through local debridement was carried out; 50% (11/22) had diabetes mellitus, and all had a positive culture of Pseudomonas aeruginosa. The frequency of recurrence was 14% (3/22), and 95% (21/22) were eventually cured. The treatment course lasted 17 days on average. Side effects caused by the drug treatment were seen in 14% (3/22), but they were mild and transient consisting of a reversible increase of the serum creatinine level. It was concluded that the treatment was short, efficient, safe, and as successful as treatment with quinolones or third-generation cephalosporins which has been reported during the past years. In our opinion, therefore, these drugs should be reserved for cases of treatment failure, development of resistance, or side effects.

Aged↗
PubMed1996

[Clinical criteria for acute maxillary sinusitis in general practice].

The purpose of the investigation was to examine the diagnostic value of various symptoms, clinical findings, erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) in acute maxillary sinusitis using the aspiration of purulent or mucopurulent from the sinus of a patient with a pathological CT-scanning as the golden standard. Of 174 patients with suspected acute maxillary sinusitis seen in general practice we found 70% to have a pathological CT-scanning and 53% to have pus or mucous pus in the sinus aspirate. Only the ESR and CRP level were found to be significantly and independently associated with a positive diagnosis as defined by the golden standard. A clinical criterion based on either an elevated ESR and/or CRP level in a patient with pain related to the maxillary sinus region had sensitivity of 0.82, a specificity of 0.57, a positive predictive value of 0.68 and a negative predictive value of 0.75, and was diagnostically superior to the clinical examination. The investigation also confirms that this disease is most likely overdiagnosed in general practice.

Acute Disease↗
PubMed1995

Predicting acute maxillary sinusitis in a general practice population.

OBJECTIVE: To evaluate the diagnostic value of symptoms, signs, erythrocyte sedimentation rate, and C reactive protein for acute maxillary sinusitis. DESIGN: Prospective cohort study. SETTING: Danish general practice in cooperation with the otorhinolaryngology and neuroradiology department at Aalborg County Hospital. SUBJECTS: 174 patients aged 18-65 years who were suspected by the general practitioner of having acute maxillary sinusitis. MAIN OUTCOME MEASURE: The independent association of symptoms, signs, erythrocyte sedimentation rate, and concentration of C reactive protein in patients with acute maxillary sinusitis defined as purulent or mucopurulent antral aspirate. RESULTS: Only raised erythrocyte sedimentation rate (P = 0.01) and raised C reactive protein (P = 0.007) were found to be independently associated with a diagnosis of acute maxillary sinusitis. The combination of the two variables had a sensitivity of 0.82 and a specificity of 0.57. CONCLUSION: Erythrocyte sedimentation rate and C reactive protein are useful diagnostic criteria for acute maxillary sinusitis.

Acute Disease↗
PubMed1994

[Keloid of the external ear].

Keloid formation is an unpredictable complication to normal scar tissue development. The etiology is unknown, although an individual predisposition may be present. There is a regional propensity for the head, neck and upper torso. The treatment is difficult, and this should be taken into consideration when cosmetic procedures are being contemplated. This type of surgery should be avoided in individuals with previous keloid formation. Four cases of keloid formation, two after ear lobe piercing and two after otoplasty are presented and a satisfying outcome of surgical revision with ensuing steroid medication is reported.

Adolescent↗
PubMed1992

Keloids of the external ear.

Keloid formation is a rare complication of normal scar tissue development, also to the surgeon who performs surgery on the external ear. We are presenting 4 cases of keloid formation which occurred after ear piercing in 2 cases and after otoplasty in another 2 cases. The treatment of keloid formation caused difficulties and is not unequivocal. Therefore we wish to present our experiences as we have seen no cases of keloid formation after otoplasty described in the literature.

Adult↗
PubMed1991

[Congenital dermoid in the rhinopharynx].

An unusual case of congenital dermoid cyst in the rhinopharynx is described. The patient presented considerable respiratory and feeding difficulties after delivery. The importance of meticulous ear, nose and throat investigation in neonates with these symptoms is emphasized.

Dermoid Cyst↗
PubMed1985

Long-term results of septoplastic operations.

161 patients treated with septoplastic operations for nasal stenosis were examined 25-64 months postoperatively. Surgery was inadequate in 32 cases (20%); in 23 this was due to the septum operation itself, in 9 to unsatisfactory or no correction of the alar insufficiency. Preoperative anterior dislocations were corrected in 64 of 76 cases, deflection of the nose in 43 of 75 cases. Late complications were few: anterior dislocations in 3 cases; small columellar retractions in 7 cases; small septal perforations in 4 cases, and saddle nose deformity in 3 cases. 35% of the patients were not satisfied with the result, but in 14 patients (9%) this was not justified according to our examination. In a further 11% the reasons for dissatisfaction were not related to the result of the operation.

Follow-Up Studies↗
PubMed1980

Secretory otitis media. Long-term observations after treatment with grommets.

Ninety children from 1 to 14 years of age with secretory otitis media were treated with grommets and reexamined 4 1/2 to 7 1/2 years after the initial treatment. A total of 173 ears were included. All but one showed unchanged or improved hearing at follow-up, and 93% of all ears had a pure tone average of 20 dB or better. Widespread changes of the tympanic membranes were associated with hearing slightly more impaired than found in association with normal or minor changed membranes. In 21%, the eardrums were normal at otomicroscopy, while tympanosclerosis was the most frequent abnormality, found in 61%. Atrophy and retraction were frequent findings. Seven percent of the ears were still being treated or showed recurrence. Perforations were found in 3%, but there were no cholesteatomas.

Adolescent↗
PubMed1979

Noise-induced hearing loss in Danish brewery workers.

An original computer-fitted diagnosis system for registration of noise-induced hearing loss (NIHL) is presented and compared with the tested persons' subjective hardness of hearing. Among 6 904 brewery workers it was found that people below 40 years only contract little NIHL during the first 5 years of noise exposure. The NIHL after more than 5 years of noise exposure is of the same magnitude as the hearing loss resulting from 10--20 years of age. The NIHL in older age groups was of a minor degree. Permanent use of hearing protectors was associated with good hearing, but the data suggest that good hearing might be the cause and not the effect of the use of hearing protection.

Adult↗