Biomedical subjects

J Rodin

Publications and source records attributed to J Rodin.

At least 19 recordsLinked to original sources

PubMed1995

Drive for thinness in black and white preadolescent girls.

This study examined racial differences in drive for thinness, a motivational variable implicated in the etiology of eating disorders. Subjects included 613 black and white preadolescent girls from one of three National Heart, Lung, and Blood Institute (NHLBI) Growth and Health Study centers. Instruments included the Drive for Thinness Scale, a Criticism about Weight scale, the Self-Perception Profile for Children, a Sexual Maturation index, and 3-day food diaries. Black girls reported significantly greater drive for thinness than white girls. Drive for thinness was significantly associated with adiposity in both groups; additional predictors included criticism about weight for black girls and dissatisfaction with physical appearance for white girls. Correlations between drive for thinness and nutrient intakes were not significant. The finding of a greater drive for thinness among young black girls is provocative, given the higher prevalence of obesity and the lower prevalence of anorexia nervosa among black women. Longitudinal follow-up will examine the significance of drive for thinness in the development of weight and eating disorders in this cohort.

Black or African American↗

PubMed1995

The relationship between weight and psychological functioning among adolescent girls.

This study investigated whether Body Mass Index (BMI) was associated with various aspects of psychological functioning in a sample of largely Caucasian adolescent girls. Three hundred sixty-five adolescent girls ranging from ages 14 through 19 were assessed for general psychological functioning utilizing the Symptom Checklist-90-Revised (SCL-90-R), and functioning specific to eating, shape and weight utilizing the Eating Disorders Inventory (EDI). Excess weight was associated with higher scores on the Bulimia, Body Dissatisfaction and Drive for Thinness subscales of the EDI. Excess weight was not, however, associated with general psychopathology or any of the subscales of the SCL-90-R. The results suggest that excess weight may carry risk for pathology specifically related to eating, shape and weight in adolescent girls, but not for general forms of psychopathology.

Adolescent↗

PubMed1995

Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice.

We have previously demonstrated that the C57BL/6J (B/6J) mouse will develop severe obesity, hyperglycemia, and hyperinsulinemia if weaned onto a high-fat, high-sucrose (HH) diet. In the present study, we compared the effects of fat and sucrose separately and in combination on diabetes- and obesity-prone B/6J and diabetes- and obesity-resistant A/J mice. After 4 months, the feed efficiency ([FE] weight gained divided by calories consumed) did not differ across diets in A/J mice, but B/6J mice showed a significantly increased FE for fat. That is, B/6J mice gained more weight on high-fat diets without consuming more calories than A/J mice. The increase in FE was related to adipocyte hyperplasia in B/6J mice on high-fat diets. Fat-induced obesity in B/6J mice was unrelated to adrenal cortical activity. In the absence of fat, sucrose produced a decreased in FE in both strains. Animals fed a low-fat, high-sucrose (LH) diet were actually leaner than animals fed a high-complex-carbohydrate diet. Fat was also found to be the critical stimulus for hyperglycemia and hyperinsulinemia in B/6J mice. In the absence of fat, sucrose had no effect on plasma glucose or insulin. These data clearly show that across these two strains of mice, genetic differences in the metabolic response to fat are more important in the development of obesity and diabetes than the increased caloric content of a high-fat diet.

Adipose Tissue↗

PubMed1994

Limited effects of HIV counseling and testing for women. A prospective study of behavioral and psychological consequences.

OBJECTIVES: To assess the consequences of human immunodeficiency virus (HIV) counseling and testing for seronegative women in terms of sexual behavior and psychological outcomes. DESIGN: The design is prospective and longitudinal, using repeated measures. Participants were interviewed at recruitment, 2 weeks later (when tested women received results), and 3 months later. SETTING: Four community health clinics in southern Connecticut; all provide HIV counseling and testing and other specialized and primary health care services. STUDY PARTICIPANTS: A sequential sample of women were recruited for two study groups: those seeking HIV counseling and testing (n = 152), and a comparison group never tested for HIV (n = 78), matched by clinic, race, and age. MAIN OUTCOME MEASURES: A composite measure of sexual risk was developed, based on sexual activity, condom use, and partner risk factors. Psychometrically valid and reliable measures of general psychological functioning and acquired immunodeficiency syndrome (AIDS)--specific psychological indicators were also used. RESULTS: Average level of sexual risk was lower for tested than nontested women at all three interviews. For both groups, there was no significant change in sexual risk from baseline to 3-month follow-up. At the individual level, there was no difference in the number of women who decreased or increased sexual risk. For tested women, intrusive thoughts about AIDS and estimated chance of getting AIDS decreased after counseling and testing. CONCLUSIONS: Behavioral and psychological consequences of HIV counseling and testing for women at risk for HIV were limited. These results have implications for further prevention interventions.

AIDS Serodiagnosis↗

PubMed1994

Medical, metabolic, and psychological effects of weight cycling.

This article reviews studies on the effects of weight cycling and weight variability on metabolism, psychological status, morbidity, and mortality. Repeated bouts of weight loss and regain, known as weight cycling or yo-yo dieting, are highly prevalent, occur in males and females, and are common in both overweight and nonoverweight individuals. While there has been no consistent demonstration that, as was first thought, weight cycling makes subsequent weight loss more difficult or regain more rapid, it is possible that this does occur under some conditions or in particular individuals. There are stronger and more consistent links between body weight variability and negative health outcomes, particularly all-cause mortality and mortality from coronary heart disease. Weight cycling may also have negative psychological and behavioral consequences; studies have reported increased risk for psychopathology, life dissatisfaction, and binge eating. The bulk of epidemiologic research shows an association of weight variability with morbidity and mortality, although the mechanisms are not clear at present. There is a clear need for further research on the effects of weight cycling on behavior, metabolism, and health. Understanding and promoting weight maintenance is an important priority.

Body Composition↗

PubMed1994

The dieting maelstrom. Is it possible and advisable to lose weight?

An impassioned debate over the virtues and dangers of dieting is polarizing the field and diverts attention from key issues. Dieting clearly has costs and, for some, has the potential for benefit. The primary challenges are (a) to identify individuals who will be helped or harmed by dieting, (b) to reduce the frequency and severity of dieting in those for whom the costs exceed the benefits, (c) to better understand the physiological and psychological reasons why some people can lose and others cannot, and (d) to develop safe and effective means for weight loss and its maintenance and to target these methods to individuals who stand to benefit.

Cognition↗

PubMed1994

Treatment considerations in postmastectomy reconstruction: their relative importance and relationship to patient satisfaction.

Although studies concerning motivation for and satisfaction with breast reconstruction after mastectomy have proliferated, little information is available concerning the relative importance of motivating factors and satisfaction with treatment choice in nonreconstructed and reconstructed mastectomy patients. We studied this by questioning 144 women in four groups: mastectomy patients who had reconstruction; mastectomy patients who did not have reconstruction; and two control groups composed of women who had not had any cancer or who had undergone hysterectomy for uterine cancer. This study was conducted just before the reports of alleged risks of silicone to the patients and reflects the opinions of patients without such bias. This study shows that, although women who opted for reconstruction reported greater concern about appearance than women who did not have reconstruction, both groups described concerns about surgical discomfort and possible complications. Also, women's concerns about appearance did not seem to fall solely into public (others' evaluations) or private (patients' own evaluation) domains. Rather, personal attitudes about appearance may affect interpersonal experiences. Finally, concerns about the possibility of recurrence may reduce patient satisfaction for some women who have reconstruction, so postsurgical education regarding cancer risk may be needed. Reconstructed and nonreconstructed mastectomy patients do not appear to differ in postoperative behaviors promoting personal health. This information, analyzed before the silicone controversy, may serve as a baseline for future research on the impact of the silicone crisis on women's perceptions regarding reconstruction.

Adult↗

PubMed1994

Biobehavioral effects of weight cycling.

An association between weight cycling and mortality and morbidity has been pointed out in epidemiological studies. However, the mechanisms underlying this association are difficult to demonstrate, and earlier studies have been contradictory. In this work we investigated several mechanisms which have been suggested as possible mediators for the association between weight cycling and a number of prevalent diseases. Fat consumption, fat preference, fat distribution and metabolism, lipid profile, oral glucose tolerance test (OGTT), blood pressure and steroid hormone determinations were performed in 28 women with or without a weight cycling history, who were matched for weight and age. No differences were found between cyclers and non-cyclers for any of the behavioral, physiological, metabolical and health parameters measured, with the exception of an increase in subcutaneous abdominal fat in the cyclers. It was concluded that, in generally healthy young women, weight cycling does not differentially increase risk factors that are harmful for health. However adverse effects might still be detectable in situations where women are biologically challenged.

Adipose Tissue↗

PubMed1992

Effect of chronic stress and exogenous glucocorticoids on regional fat distribution and metabolism.

It has been proposed that increased glucocorticoid hormones and decreased sex hormones affect regional fat metabolism and distribution. In the present work, it was hypothesized that chronic, uncontrollable stress, known to affect the pituitary-adrenal and pituitary-gonadal axes might, therefore, lead to differences in regional fat accumulation. In comparison with controls, male Sprague-Dawley rats stressed for 28 days, had significantly larger adipocytes. In addition, a tendency for a heavier fat pad and an increased lipoprotein lipase activity in the mesenteric depot was suggested. No significant changes were seen in epididymal, retroperitoneal, and inguinal regions. In order to study if the effects observed could be attributed to increased glucocorticoids, the response to a direct administration of supraphysiological doses of corticosterone, given either in the drinking water or via subcutaneous implantation of corticosterone pellets, was studied. Increased fat accumulation was shown in all fat depots in a dose-response fashion, but was significantly more pronounced in the mesenteric region. It was concluded that mesenteric fat tissue may respond to stress in a different manner from other fat depots. Glucocorticoids seem to be partly, but not solely, responsible for the changes observed in adipose tissue metabolism and distribution following exposure to uncontrollable stress.

Adipose Tissue↗

PubMed1992

Modulation of human natural killer cell activity by exposure to uncontrollable stress.

Changes in natural killer cell (NK) activity and proportions of circulating T and NK lymphocyte subsets were assessed in adult males immediately after exposure to controllable or uncontrollable stress (noise) as well as 24 and 72 h later, in order to track the time course of the effects of stress. The role of control-relevant personality variables as moderators of the stress-immunosuppression relationship was considered. Subjects who perceived they had control over the noise as well as no-noise "control" subjects showed no reduction in NK activity. By contrast, subjects who perceived that they had no control over the stressor showed reduced NK activity immediately after the conclusion of the first 20-min stress session, and the reduced NK activity was found as long as 72 h later. Optimism and one's desire to be in control enhanced the negative impact of uncontrollable noise on NK activity. No differences between conditions were found on number of NK cells or a variety of T cell subsets. The results suggest the importance of perceived control in moderating the short- and long-term effects of stress on NK activity.

Adolescent↗

PubMed1992

Women and AIDS in the United States: epidemiology, natural history, and mediating mechanisms.

The number and proportion of women with the human immunodeficiency virus (HIV)1 and acquired immunodeficiency syndrome (AIDS) have increased rapidly throughout the past decade. Despite these increases, research attention on women with AIDS has been relatively scarce until recently. It is likely that there are important sex differences at all phases of the disease process-from prevention, through viral exposure, diagnosis, and living with HIV, to treatment for AIDS. Therefore, research findings from studies of men may not all be extended reliably to women with HIV and AIDS. In this article, we review the literature on U.S. women in particular and discuss what differentiates these women from their male counterparts with the disease. We begin with an epidemiologic review and description of the natural history of the disease to lay the foundation for a more complete understanding of the biological and psychosocial factors relevant to AIDS in women. The association between psychosocial mechanisms--including stress, control, and social support--and immune-mediated disease outcomes is discussed in detail. Implications for research, prevention, and treatment also are considered.

Acquired Immunodeficiency Syndrome↗

PubMed1992

Relation of level of exercise, age, and weight-cycling history to weight and eating concerns in male and female runners.

We examined the association between level of exercise and degree of weight preoccupation in a large sample of male and female runners, as well as risk factors posited to influence weight and eating concerns in the general population. Subjects were 2,459 males and 1,786 females who had completed a questionnaire on weight and eating concerns in a national running magazine. Eight percent of the males and 24% of the females had symptomatic scores on the Eating Attitudes Test (EAT). Exercise level, defined as weekly running mileage, was positively associated with excessive weight and eating concerns in males but not in females. Both sexes with a history of weight cycling were more likely to have symptomatic EAT scores than those with no such history. These results highlight the importance of studying these concerns in males as well as females and of examining the role of exercise level and weight-cycling history in the development of serious weight preoccupations.

Adolescent↗

PubMed1992

Determinants of change in perceived health in a longitudinal study of older adults.

To determine the factors that are predictive of a negative decline in perceived health in a longitudinal study of 251 men and women aged 62 and older, we developed a "synthetic" cohort of individuals who experienced a decline in perceived health between two time points and a control cohort of those who did not. The longitudinal design of the study made it possible to evaluate the effects of "baseline" predictors, gathered prior to the time interval during which the reported change in perceived health occurred, in addition to measures assessed at the two time points between which the change in health was reported. Hierarchical logistic regression models were used to examine the effect of demographic, psychosocial, and illness measures on change in perceived health. These analyses revealed that increases in new illnesses, increased physician visits, and worsening of preexisting conditions (in subjects who had higher feelings of self-efficacy) were all associated with a decline in perceived health, after controlling for the effects of baseline illnesses and medication use. After accounting for these effects of changes in objective illness indicators, we found that changed psychosocial factors also predicted a decline in perceived health. Lower life satisfaction and higher depression at baseline were predictive of a later decline in perceived health. In addition, data collected at the third consecutive time point were evaluated to assess determinants of a sustained vs transient decline in perceived health. A sustained decline in perceived health was associated with increased depression and decreased self-efficacy.

Aged↗

PubMed1992

Pregnancy alters blood pressure responses to psychological and physical challenge.

The purpose of the study was to evaluate the effect of the substantial changes in female reproductive hormones that occur during normal pregnancy on cardiovascular responses to psychological and physical challenges. Twenty-one healthy normotensive women performed serial subtraction, mirror image tracing, and isometric handgrip exercise tasks prior to pregnancy and again during the second trimester of pregnancy. A control group of 34 healthy women who did not intend to become pregnant and were nonpregnant were also tested in the same protocol twice, 6-10 months apart. Results showed that the pregnant women exhibited a reduced diastolic blood pressure response to all three tasks, relative to their pre-pregnancy levels, whereas nonpregnant controls did not change in their diastolic blood pressure response across time. These results are consistent with the hypothesis that elevations in female reproductive hormones diminish blood pressure responses during challenge because of dampened sympathetic nervous system activity.

Adolescent↗

PubMed1991

Food cravings in relation to body mass index, restraint and estradiol levels: a repeated measures study in healthy women.

The study considered the nature and extent of cravings in 108 healthy women between the ages of 20 and 37 who were tested at four time points over a 2-year period. There was substantial consistency over the four widely separated time points (3 months-1 year) in the types of foods craved, with chocolate and ice cream highest on the list, followed by fatty and spicy foods, and sweets. Women with a higher body mass index reported more consistent cravings for salty foods, especially those with high flavor intensity. There were no significant relationships between dietary restraint and the number, frequency or types of cravings. There were also no strong relationships between estradiol levels and the number, frequency or types of cravings women reported in the whole sample. The data suggest that women have a stable core of foods for which they experience cravings, relatively independent of estradiol levels, BMI or degree of dietary restraint.

Adult↗

PubMed1991

Effects of pure sugar vs. mixed starch fructose loads on food intake.

Using a within-subject design, we gave subjects three different 520-530 kcal preloads in the form of puddings in a randomized fashion at weekly intervals. The puddings contained either 50 g of fructose or glucose as the sole carbohydrate source in a protein and fat mixture, or 50 g fructose plus 15 g of starch. Food intake was assessed 2.25 h after the preload was completed. Blood was drawn throughout and assayed for concentrations of glucose and insulin. When the preload contained fructose alone as the sole source of carbohydrate, subjects ate significantly fewer calories and less fat than when the preload contained glucose alone. When starch was added to the fructose preload, there was no significant reduction in calorie and fat intake. Effects on food intake paralleled the rise in plasma insulin levels produced by the different preloads. Implications for use of fructose as an adjunct to weight control efforts are discussed.

Adult↗

PubMed1991

Mothers, daughters, and disordered eating.

We examined features of 77 mothers' attitudes and behavior that relate to disordered eating among their adolescent daughters. Mothers whose daughters reported a level of disordered eating comparable with clinical samples of bulimic patients were compared with mothers whose daughters reported a low level of eating disturbances. As hypothesized, mothers of daughters with disordered eating were more dissatisfied with the general functioning of the family system. Also, mothers whose daughters were eating disordered were themselves more eating disordered and differed in their dieting history compared with mothers of the girls who were not eating disordered. Furthermore, mothers of girls with disordered eating thought their daughters should lose more weight than mothers of girls who were not eating disordered. They also thought that their daughters were less attractive than the girls judged themselves.

Adolescent↗

PubMed1991

Explanatory style and cell-mediated immunity in elderly men and women.

Correlated pessimistic explanatory style--the belief that negative events are caused by internal, stable, and global factors--with lowered immunocompetence in a sample of 26 older adults. Two measures of cell-mediated immunity--T-helper cell/T-suppressor cell ratio and T-lymphocyte response to mitogen challenge--were lower in individuals with a pessimistic style, controlling for the influence of current health, depression, medication, recent weight change, sleep, and alcohol use. A relative increase in the percentage of T-suppressor cells seemed to underlie this immunosuppression. Although the mechanism by which explanatory style might influence immune function remains unknown, we speculate that a pessimistic style might be an important psychological risk factor--at least among older people--in the early course of certain immune-mediated diseases.

Aged↗