[Chronic pulmonary heart in obstructive lung diseases: new physiopathological aspects].
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Biomedical subjects
Publications and source records attributed to J Rochemaure.
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The retrospective study of 102 epidermoid carcinomas of bronchial radically treated by surgery enables a survey of various prognostic factors, assessing the post-operative evolution over 2 years for 98 patients and over 5 years for 68 others. Some signs are ominous: chest pains or a worsening general condition in the preoperative symptomatology. On the other hand, the effect of the delay between the first symptoms and the intervention has not been demonstrated. Two factors, so far not much valued, have also been studied: the condition of the bronchial section of little prognostic value and, on the other hand, the TNM systematic classification which seems valuable for all operated bronchial cancers.
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The different anatomical zones of the lung show a high degree of variation in metabolic function, involving many protein molecules and complex enzyme systems. Recent data in the literature concerning such activity are described with respect to bradykinin, fibrinolysis, haemostasis, angiotensin, serotonin, catecholamines, prostaglandins, vaso-active amines, the protease-antiprotease system and benzopyrene-hydroxylase.
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Presentation of a case of Wegener syndrome with two remarkable atypisms: multiple visceral localizations and evolution lasting over 17 years without any chemotherapy. Discussion of these abnormalities, particularly of the importance, in this slow evolution, of an early exeresis of the granuloma in the upper airways.
Report of an anatomical-clinical study concerning 173 patients with an average follow-up period of 5 and 1/2 years after the onset of myocardial infarction. They were subdivided into four comparable groups differing only in the quality of the long-term antivitamin K treatment which was administered. A survey of the coronary artery and myocardial lesions was performed for every heart. Acute occlusive coronary artery thromboses were four times less frequent in the correctly treated group then in the other three groups (p less than 0.001). There was no significant difference between the insufficiently treated groups and the untreated group. Recurrent myocardial infarctions were accompanied in 90 per cent of cases by acute occlusive coronary artery thromboses and were four times less frequent when treatment was efficient (p less than 0.001). These results confirm the part played by coronary artery thrombosis in the aggravation of coronary atherosclerosis and justify the attempts at long-term prophylaxis. The provide the proof that antivitamin K administration, at efficient dosage, maintained for a long time, has a significant influence on the cause of death in these patients, by decreasing the number of coronary artery thrombosis. Long-term anticoagulant treatment, in spite of its haemorrhagic complications and limits, should not be given up until a new efficient treatment is available.
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