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Biomedical subjects

J Robins

Publications and source records attributed to J Robins.

51 records · Page 3Linked to original sources
PubMed1976

The use of silastic vaginal device containing (15S)-15 methyl prostaglandin F2 alpha methyl ester for early first trimester pregnancy termination.

(15 S) - 15 methyl prostaglandin F2 alpha methyl ester in a silastic vaginal device was administered to 9 gravid women in the first 7 weeks of gestation for elective termination of pregnancy. Continuous intrauterine pressure recording was carried out in one case. Prompt initiation of uterine activity and vaginal bleeding was seen and expulsion of products of conception occurred in under 24 hours in all cases. There were no serious complications and side effects were considered acceptable. Two patients have required subsequent curettage for removal of retained placental tissue. This incidence of failure to complete expulsion, if confirmed in a larger series, is considered to render this technique without modification unacceptable as a routine method for early pregnancy termination.

Abortion, Induced↗
PubMed1975

Midtrimester pregnancy termination by intramuscular injection of a 15-methyl analogue of prostaglandin F2 alpha.

Fifty patients between 12 and 20 weeks' gestation were treated with prostaglandin 15 (S) 15-methyl F2 alpha by repeated intramuscular injection of 250 mug at intervals of not less than 2 hours in order to evaluate its efficacy as an abortifacient. A success rate of 96 per cent was achieved with a mean initiaation-abortion interval of 16.5 +/- S.E.M. 1.12 hours. There were no serious complications. The most common side effects were vomiting in 82 per cent and diarrhea in 66 percent of cases. The abortifacient activity was correlated with serial serum progesterone determinations and continuous intra-amniotic pressure recordings in selected cases.

Abortifacient Agents↗
PubMedDate not supplied

Analysis of semi-parametric regression models with non-ignorable non-response.

In this article we consider the problem of making inferences about the parameter beta zero indexing the conditional mean of an outcome given a vector of regressors when a subset of the variables (outcome or covariates) are missing for some study subjects and the probability of non-response depends upon both observed and unobserved data values, that is, non-response is non-ignorable. We propose a new class of inverse probability of censoring weighted estimators that are consistent and asymptotically normal (CAN) for estimating beta zero when the non-response probabilities can be parametrically modelled and a CAN estimator exists. The proposed estimators do not require full specification of the likelihood and their computation does not require numerical integration. We show that the asymptotic variance of the optimal estimator in our class attains the semi-parametric variance bound for the model. In some models, no CAN estimator of beta zero exists. We provide a general algorithm for determining when CAN estimators of beta zero exist. Our results follow after specializing a general representation described in the article for the efficient score and the influence function of regular, asymptotically linear estimators in an arbitrary semi-parametric model with non-ignorable non-response in which the probability of observing complete data is bounded away from zero and the non-response probabilities can be parametrically modelled.

Data Interpretation, Statistical↗
PubMedDate not supplied

Subclinical effects and fenbendazole treatment of turkey ascaridiasis under simulated field conditions.

Under simulated natural conditions of bird production and parasite challenge, the effects of ascaridiasis and the effectiveness of fenbendazole treatment (6-day regimes in the feed at 16 ppm) were documented. Birds were artificially challenged with ascarid larvae on a daily basis from day 35 to 112, with bird grow out ending on day 119. Experimental groups, on a per pen basis, were infected control, treated with fenbendazole at days 63-69, treated with fenbendazole at days 63-69 and days 91-97, and uninfected control. In the same order as above, and on an experimental group mean bird basis, final weights were 13.34, 13.47, 13.59, and 13.78 kg, average daily gains from day 7 to day 119 were 117.8, 118.9, 120.1, and 121.8 g, and units gained per unit of feed consumed from day 7 to day 119 were 0.337, 0.341, 0.347, and 0.362. Infected control bird mean Ascaridia dissimilis burdens, with all stages combined, ranged from 351.1 on day 63 to 117.2 on day 91, levels seen commonly with naturally infected commercial turkeys. Trial data dearly indicated that moderate A. dissimilis burdens negatively impacted animal performance (average daily gains and feed efficiencies) and that these parasite burdens are effectively removed by fenbendazole treatment.

Analysis of Variance↗
PubMedDate not supplied

Seen and not heard.

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Communication↗