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Biomedical subjects

J Ring

Publications and source records attributed to J Ring.

At least 541 records · Page 30Linked to original sources
PubMed1980

[Kerion celsi. Clinical aspects and pathogenesis of deep trychophytosis of the scalp].

Kerion Celsi (scalp ringworm) is a highly inflammatory, suppurative fungal infection of the scalp caused by zoophilic dermatophytes transmitted from animals to man. The clinical picture extends to patchy infiltrated suppurative lesions in which hairs are broken or eliminated completely. Diagnosis is performed by detection of the organisms in or around the hairs involved and through culture. Kerion Celsi is treated with griseofulvin orally in combination with local symptomatic and antimycotic therapy. In the beginning systemic glucocorticoids might possibly be of help reducing the risk of scar formation and irreversible alopecia.

Child↗
PubMed1980

[Problems of intravenous gammaglobulin therapy (author's transl)].

The presently available i.v. gammaglobulines (GG) can be classified into two groups. Degraded GG are produced by pepsin or plasmin digestion. Intact GG are obtained by beta-propiolactone treatment, acidification at pH or precipitation with polyethylenglycol-hydroxyethylstarch (PEG/HES). The various products have different characteristics with regard to their biological activity (certain functions of complement activation and opsonization are connected with the Fc structure) as well as their elimination (intact GG have longer intra- and extravasal half-life times). While their is no doubt about an effect of GG in animal experiments, little controlled studies have been done for most of the clinical indications. One controlled prospective study showed that in surgical high risk patients the frequency of septic complications can be reduced by prophylactic application of high doses of 7 S-GG. For the future, the development of a broad spectrum of hyperimmunoglobulines seems desirable.

Humans↗
PubMed1980

[Efficacy of intravenous gammaglobulin in bacterial infections in Surgical Patients. Results of a controlled, randomized clinical study (author's transl)].

The efficacy of intravenous gammaglobulin injections against postoperative bacterial infections was investigated in a prospective randomized, controlled clinical trial in 150 patients. It was found that after postoperative administration of 20 g i. v. gammaglobulin (Intraglobin) the preoperative serum levels had already been attained on the third day (without gammaglobulin they were lower than before operation on the 8th postoperative day). By means of this substitution it was possible to reduce the number of local infections (p less than 0.01) where moderate risk existed. With more persistent infections the incidence of septicemic complications were lower (p less than 0.05). On the basis of these results the application for certain indications of high doses of intravenous gammaglobulin discussed.

Clinical Trials as Topic↗
PubMed1980

The in vitro effect of levamisole on lymphocyte proliferation, polymorphonuclear leucocyte chemotaxis, basophil histamine release and platelet serotonin release in patients with atopic dermatitis.

The in vitro effect of levamisole (LMS) on lymphocyte, neutrophil, basophil and platelet function was investigated in patients with severe atopic dermatitis and hyperimmunoglobulinaemia E. Lymphocyte stimulation by several concentrations of PHA, con A and PWM, polymorphonuclear leukocyte chemotaxis and basophil histamine release were unaffected by LMS (10 micrograms/ml). Platelet serotonin release induced by iodipamide was decreased in patient and control groups by LMS but release induced by methacholine, epinephrine and thrombin was not.

Basophils↗
PubMed1980

Intravascular persistence of hydroxyethyl starch (HES) after serial granulocyte collections using HES in man.

In 30 granulocyte donors undergoing one or more infusions of 6% hydroxyethyl starch (HES) solution plasma HES concentrations were measured by single radial immunodiffusion. Serial HES applications led to a cumulative increase in plasma HES levels. Up to 3 months after the last HES infusion, plasma concentrations in the range of 3 mg/ml were demonstrable. A possible influence of HES deposits upon reticuloendothelial system function is discussed.

Adult↗
PubMed1980

[Does i.v. gamma globulin counteract postoperative bacterial infections? (authors's transl)].

A prospective, randomized clinical study investigated the effectiveness of IV gamma-globulin (GG) against bacterial infections after surgical procedures. As a result of 20 g GG IV, given postoperatively, the average concentration decrease for IgG (25% - 30%) could be balanced as soon as the third postoperative day, the local infection rate was decreased in the low-risk group, and, with the occurrence of long-lasting local infections, the number of patients with simultaneous septic complications was lowered.

Bacterial Infections↗
PubMed1980

In vitro releasability of histamine and serotonin: studies of atopic patients.

Sixteen atopic patients with anaphylaxis to food, eczema, asthma and/or rhinitis were investigated for in vitro reactivity of their leukocytes and platelets to various stimuli. Leukocytes from two patients with anaphylaxis to foods had very high spontaneous release of histamine. Compared to non-atopic volunteers without respiratory disease, leukocytes from the other atopic patients showed increased histamine release after stimulation with methacholine in concentrations between 10(-2) and 10(-6) M. Histamine release induced by anti-IgE or anti-kappa chain serum was slightly decreased in atopics compared to controls, and was significantly decreased at low concentrations of anti-IgE (p less than 0.05). There was no significant difference of means for histamine release induced by the calcium ionophore A-23815. The uptake of 3H serotonin from platelet-rich plasma of atopic patients appeared to occur more slowly than in non-atopics. Serotonin release from washed platelets after stimulation with aggregated IgG was significantly lower in the atopic group (p less than 0.01). There was no significant difference in serotonin release induced by thrombin, epinephrine, ionophore or methacholine. Alterations in releasability of mediator containing cells to immunologic and non-immunologic stimuli may play a role in the expression of atopic disease.

Adolescent↗
PubMed1980

[The spectrum of antinuclear and anticytoplasmatic antibodies in collagenoses].

This article gives a review of antinuclear and anticytoplasmatic antibodies and their profile and antigen specificity in systemic rheumatic disease. Available methods for the detection of these autoantibodies are summarized and their diagnostic and prognostic value for autoimmune disorders discussed.

Abnormalities, Multiple↗
PubMed1979

[Risk of incompatibility reactions in the repeated use of contrast media in urography].

In a prospective study 260 urographies were evaluated regarding clinical compatibility. In altogether 11% of the patients mild incompatibility reactions were observed (heat sensation, urticaria, nausea, vomiting). 29% of the patients with known prior contrast agent incompatibility suffered from anaphylactoid symptoms mostly of a subjective type (heat sensation, nausea). There was no statistically significant difference in the frequency of objective symptoms (urticaria, vomiting) between patients with prior contrast media incompatibility (3%) and patients who had tolerated previous contrast media applications without symptoms (2%).

Anaphylaxis↗
PubMed1979

Integration and transcription of mouse mammary tumor virus DNA in rat hepatoma cells.

Rat hepatoma cells infected with mouse mammary tumor virus (MMTV) acquire viral DNA that becomes covalently linked to the cell DNA. Using restriction endonucleases and the DNA transfer procedure of Southern [Southern , E.M. (1975) J. Mol. Biol. 98, 503--517], we have studied the sites in cellular DNA into which MMTV DNA inserts. These experiments indicate that: (i) there are many sites in cell DNA into which MMTV DNA integrates; (ii) the junctions between viral and cellular DNA occur within a limited portion of the viral genome, (iii) clones that contain MMTV DNA do not necessarily produce viral RNA; and (iv) the extent of transcription and glucocorticoid responsiveness of MMTV proviruses may be dependent on the site(s) in cell DNA in which the viral DNA resides.

Animals↗
PubMed1979

Plasma complement and histamine changes in atopic dermatitis.

Fifteen patients with atopic dermatitis were investigated to evaluate the total of complement and histamine. In five patients total serum complement haemolytic activity (CH50) was significantly decreased as was the haemolytic activity of complement components C2 (C2H50) and C3 (C3H50). By counter immunoelectrophoresis split products of C3 were detected. There was no evidence for alternative pathway activation or the presence of an activator of the alternative pathway. In three patients plasma histamine concentrations were elevated. The intensity of the complement and histamine changes observed seemed to be correlated to the severity of the disease.

Adolescent↗