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Biomedical subjects

J Righter

Publications and source records attributed to J Righter.

32 records · Page 2Linked to original sources

Blastomycosis: a new endemic focus in Canada.

A survey of the 38 patients resident in Ontario from whose sputum, body fluids or tissues Blastomyces dermatitidis was cultured by our laboratory between 1970 and 1981 revealed a new endemic focus to the north and east of Lake Superior, where 20 of 27 traceable patients lived. Direct microscopy revealed B. dermatitidis in 90% of the cases. A lack of clinical awareness, however, had often resulted in a delay (average 15 weeks) in diagnosis. In two cases the disease was identified only at autopsy. About 80% of the patients survived.

Blastomycosis↗

Mycobacterium chelonei: report of a case of septicemia and review of the literature.

Mycobacterium chelonei was originally included in group IV of Runyon's classification of "anonymous" or "atypical" mycobacteria. Although a frequent contaminant without clinical significance, this organism has definite pathogenic potential. A compromised host with M. chelonei septicemia and disseminated candidiasis is described. A review of the literature on M. chelonei human infections is also presented.

Alcoholism↗

Infection and peripheral venous catheterization.

A prospective bacteriological and clinical study was carried out to determine the incidence of local and systemic infection associated with peripheral venous catheterization in a 630-bed general hospital with 24 hr intravenous team coverage. In all, 1,696 cannulas were obtained using standardized techniques and were cultured by a semiquantitative method on solid media. 41 cannulas (2.4%) yielded positive cultures (15 or more colonies). An additional 318 (18.8%) showed lesser growth indicative of contamination. No case of septicemia was encountered. Local signs of inflammation showed no correlation with positive cannula culture. The semiquantitative culture technique is easily performed and yields clear results. However, the upper limit for the number of colonies which should be regarded as contamination and criteria for phlebitis require further study. Although the infective risk of peripheral venous catheterization must not be ignored, an extremely low rate can be achieved with continuous IV team coverage and strict aseptic technique.

Bacterial Infections↗

Netilmicin: in-vitro activity compared with that of other aminoglycosides against Serratia marcescens.

The activity of netilmicin, a semisynthetic aminoglycoside, was compared with that of gentamicin, tobramycin, and amikacin against 100 clinical isolates of Serratia marcescens. Minimum inhibitory concentrations (MIC) were determined by an agar dilution procedure. Defining amikacin resistance as an MIC of greater than 16 mg/l, and netilmicin, gentamicin and tobramycin resistance as an MIC greater than 4 mg/l, 1% were resistant to amikacin, 3% to netilmicin, 8% to tobramycin, and 43% to gentamicin. The majority of isolates that were resistant to both gentamicin and tobramycin were sensitive to netilmicin. These results indicate that the activity of netilmicin against Ser. marcescens is closely comparable to that of amikacin.

Aminoglycosides↗

Hemophilus vaginalis bacteremia.

During 1975--77 Hemophilus vaginalis bacteremia occurred post partum in eight previously healthy women. Seven had been admitted for delivery at term and one because of threatened abortion. Six underwent cesarean section. Post-partum pyrexia and neutrophilia were the main features. All the patients recovered uneventfully while receiving antibiotics. H. vaginalis is an infrequent agent of bacteremia; it affects predominantly women after obstetric trauma.

Anti-Bacterial Agents↗