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Biomedical subjects

J Rigó

Publications and source records attributed to J Rigó.

At least 37 records · Page 2Linked to original sources
PubMed1997

[Bilateral renal artery stenosis diagnosed during pregnancy].

Bilateral renal artery stenosis was diagnosed noninvasively in the 17th gestational week, in a chronically hypertensive pregnant woman, by renal artery duplex ultrasound examination, MRI and MR angiography. Continuous monitoring of the mother and the fetus was performed. Blood pressure was stabilized by complex antihypertensive therapy, but from the beginning of the third trimester superimposed preeclampsia developed gradually. In the 34th gestational week a 1600-g newborn was delivered by elective cesarean section. The case report draws attention to the significance of the thorough examination of hypertensive women before pregnancy.

Adult↗
PubMed1996

Coumarin-induced skin necrosis following heparin-induced thrombocytopenia and thrombosis. A case report.

A severe thrombotic thrombocytopenic status, induced by heparin in a sixty-nine-year-old woman undergoing total hip joint arthroplasty, was treated by switching the anticoagulant therapy to coumarin, which induced skin necrosis. There appeared to be a possible causal relation between the severe immune reaction to heparin and the condition that predisposed to skin necrosis in the presence of coumarin. In patients who express a strong immune response to heparin, a different anticoagulant approach other than use of coumarin congeners appears to be justified.

Aged↗
PubMed1996

Pemberton's pericapsular osteotomy for the treatment of acetabular dysplasia.

We present the results of 80 Pemberton procedures carried out between 1977 and 1990. The patient age at the time of operation ranged between 2 and 12 years, and follow-up was between 1 and 15 years. Before Pemberton's operation, conservative treatment, closed and open reduction, and derotation femoral osteotomy were used. Pemberton's operation was combined with intertrochanteric femoral osteotomy in 30 cases. The mean values of the acetabular and center edge angle of Wiberg showed postoperative improvement of 19 and 17 degrees, respectively; whereas at follow-up, improvement was 20 and 23 degrees, respectively. Radiologically, 79% of the cases met Severin's classification grade I-II criteria. Clinically, 81% were classified as excellent and good. The results were closely correlated with ischemic necrosis due to preoperative treatment. Only patients belonging to groups II-IV of Kalamchi and MacEwen, plus one patient operated on at relatively old age (12 years), were found radiologically to be in Severin's groups III and IV. The results among patients operated on before age 7 were more favorable than those of patients operated on at an older age.

Acetabulum↗
PubMed1996

Signal transduction in human myometrial cells.

Calcium plays a pivotal role in the contraction-relaxation cycle of uterine smooth muscle. We investigated the effects of three uterine agonists; prostaglandin F2 alpha (PGF2 alpha), oxytocin and platelet activating factor (PAF) on intracellular levels of Ca ([Ca2+]i) in intact human myometrial cells and 45Ca2+ efflux from permeabilized myocytes. We observed that, whereas oxytocin and PAF activated the phosphoinositide cycle, generating inositol triphosphate to mobilize intracellular Ca2+, PGF2 alpha acted mainly to enhance Ca2+ influx. Oxytocin-, but not PGF2 alpha-elicited responses were suppressed by pertussis toxin. It is concluded that all three agonists act by regulating [Ca2+]i in myometrial cells, but the signal transduction mechanism of PGF2 alpha differs from that of oxytocin and PAF.

Calcium↗
PubMed1995

[The role of vascular nitric oxide (NO) in the pathomechanism of pre-eclampsia].

The significance of nitric-oxide as a biological mediator is increasingly elucidated in various physiological processes. In addition to the endothelium dependent vasodilator effect it also plays an important role as a neurotransmitter. Possible synthesis of endothelial nitric-oxide is an essential factor in the regulation of blood pressure and utero-placental circulation. Recently the relationship of nitric-oxide and preeclampsia has extensively been studied. The results of human studies and animal experiments suggest that insufficient production of endothelial nitric-oxide probably has an important role in the pathomechanism of preeclampsia.

Animals↗
PubMed1995

[Effect of preeclampsia on neonatal morbidity].

In this study the outcome of two groups of premature infants born by caesarean section were compared from 52 hypertensive mothers with severe pre-eclampsia and from 30 normotensive mothers. The indication of caesarean section in pre-eclampsia was: proteinuria (> 500 mg/24 h), high blood pressure (> 160/100 mmHg), abnormal cardiotocogram and abnormality in flowmetry (fetal distress). Every infant was premature as well as in the control group. Significantly smaller mean birthweight and longer nursing-time in neonatal intensive care unit (NICU) were found in the pre-eclamptic group. Neonatal illnesses and complications are more frequent in the pre-eclamptic group. The time of ventilation was also longer. There are more early neurological disorders in the pre-eclamptic group than in the control one. The authors can establish that pre-eclamptic toxemia increases the morbidity in the neonatal period. This is due to the chronic intrauterine fetal distress as well as the retardation.

Cesarean Section↗
PubMed1995

[Syncumar-induced necrosis following heparin-induced thrombocytopenia and thrombosis].

The authors describe the combined occurrence of heparin-induced thrombocytopenia and cumarin-induced skin necrosis, a rare condition that has not yet been reported in Hungary. The 69-year-old woman had received prophylactic heparin treatment prior to total hip arthroplasty. The first complication that the anticoagulant therapy brought about was serious thrombocytopenia paradoxically associated not with bleeding but with deep vein thrombosis. The latter necessitated coumarin therapy which resulted in severe skin necrosis.

Acenocoumarol↗
PubMed1995

Proposed signaling role of arachidonic acid in human myometrium.

The objective of this study was to test the hypothesis that, in human myometrial cells (HMC), PGF2 alpha and oxytocin promote the release of arachidonic acid (AA) which, in turn, acts to mobilize intracellular Ca2+. Primary monolayer cultures of HMC were labeled with [3H]arachidonic acid ([3H]AA) to isotopic equilibrium before exposure to PGF2 alpha or oxytocin. Radiolabeled phospholipids were separated on thin layer chromatography and quantitated by scintillation counting. Prostanoids were analyzed by high performance liquid chromatography. Calcium release was quantitated in digitonin-permeabilized myocytes preloaded with 45Ca, in the presence of ATP and ruthenium red. PGF2 alpha (10(-7) M) caused a rapid (peaking at 2 min), and significant (P < 0.01) increase in [3H]AA release that was derived selectively from phosphatidylethanolamine (PE), indicative of phospholipase A2 activation. Oxytocin caused a rapid (30 s) and significant increase in diacylglycerol, concomitant with a drop in phosphoinositides, as well as an increase in [3H]AA and a fall in PE and phosphatidylcholine. Exogenous AA caused a rapid and dose-related efflux of 45Ca2+, which was not inhibited by blockers of AA metabolism, or by heparin that abolished inositol 1,4,5-trisphosphate-induced 45Ca2+ release. It is concluded that PGF2 alpha and oxytocin promote, by different mechanisms, the release of AA, which in turn may amplify their action by enhancing Ca2+ mobilization from the sarcoplasmic reticulum, thereby fulfilling the role of intracellular signaling molecule in human myometrium.

Arachidonic Acid↗
PubMed1995

[Insulin concentration in amniotic fluid in mid-term pregnancy].

Insulin concentrations of 284 amniotic fluid samples were assessed, obtained from pregnant women by genetic amniocentesis between the 16-18 gestational weeks. The indication of amniocentesis was either advanced maternal age (> 35 years) or high risk genetic history. The amniotic fluid insulin concentration (mean +/- SD) was found 3.8 +/- 3.0 microIU/ml. The insulin concentration in 4.3% of all pregnant women was higher than the mean value +2 SD (9.8 microIU/ml) which represents individual pathological value, characteristic for gestational diabetes. Our data suggest that one part of gestational diabetes might be detected between the 16-18 gestational weeks, therefore we propose an earlier screening as the usual one. At institutes where the possibility of genetic amniocentesis is given the determination of insulin level in amniotic fluid may be reasonable. We could analyze the outcome of 230 pregnancies analysed. A close correlation was found between the amniotic fluid insulin concentration and birthweights of female newborns. It could not found such correlation at male newborn. A more careful screening test for gestational diabetes should be performed at mothers with female fetuses.

Amniocentesis↗
PubMed1994

[Experience with peflacine in the treatment of osteomyelitis].

Authors report on the treatment of 20 chronic osteomyelitis patients in whom direct antibiotic therapy was performed using the preparation Péflacine. The infected area was exposed in every case, the bony focus was excised and the wound was drained. During the operation, as an induction 800 mg Péflacine in slow drop infusion was given. Oral preparation (2 x 400 mg/die) followed, and was continued for 30 days. The secretion of the wounds ceased in every case, after 3 weeks the latest. In 2 cases mild gastrointestinal symptoms as side effects were observed. Relapse the first time occurred 5-7 months after ending the treatment in 3 patients. These were again explored and after the excision more thorough than before the secretion ceased. According their experience and in conformity with the literature the Péflacine is held an effective medicament in the treatment of the acute exacerbation of chronic osteomyelitis, together with the excision of the focus.

Administration, Oral↗
PubMed1994

[Experience with rocephin in orthopedic practice].

Authors report on the results of Rocephin prophylaxis in 30 total prostheses. The dose of the preparation was 2g/day. It was given 3 times in intravenous drop infusion 1-1.5 hours before the operation and on the second and third day. The drains were then removed. During 1 year observation no wound infection was observed. As a postoperative complication exacerbation of chronic bronchitis, existing already since years, was found. This however healed after 5 and 6 days of Rocephin and expectorant treatment. As side effect of the medicament, in single cases, vomiting, stomatitis, thrombocytopenia and allergic dermatitis were observed. It is stated, based on own experience, that the broad spectrum Rocephin, belonging to the third generation cephalosporins, securing a 24 hours bactericide activity, is suitable in a single 2g dose/day in hip endoprosthesis to prevent postoperative infections.

Aged↗
PubMed1993

[Surgical-technical problems of triple pelvic osteotomy. Early results of the polygonal method].

Since the first description of the triple pelvic osteotomies papers reporting on the improvement of the operative technique were continuously published. This is explained by the more problematic details of the operation. Authors worked out to the technique of the polygonal triple pelvic osteotomy, published by Kotz, Dávid and Uyka, a new exposure that makes more simple, quick and safe the performance of the operation. The essential feature is that the os ischii is reached after the osteotomy of the trochanter major from a lateral exposure and so the field of operation can be widely surveyed. At the same time transposition can also be performed. The experiences gained in 12 operations are reported, 8 of which were made according to their own method (follow-up: 8-22 months, in average 15 months). The patients were 14-33 years old and their complaints disappeared in every case. Authors suggest the operation for the correction of the dysplastic acetabulum in young adults and also in puberty after the fusion of the Y cartilage if no subluxation exists. Minor articular deformity and mild arthrosis are not considered as a contraindication.

Adolescent↗
PubMed1993

[Experience with the implantation of porous coated hip endoprostheses and primary stability of implantation].

The use of porous coated cementless prosthesis, shows a worldwide spread in consequence of the advantages given by the "live" connection between the implant and the bone. Based on 40 implantations of prostheses of this type (Duraloc 1200 acetabulum, AML shaft) authors report on the technique of the implantation and the primary stability reached. In consequence of the formation, the variety of size and the properly usable instruments for implantation, the prostheses could be used for every kind of deformed, dysplastic hips and good primary stability was reached in every case operated.

Adult↗