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Biomedical subjects

J Richter

Publications and source records attributed to J Richter.

At least 289 records · Page 16Linked to original sources
PubMed1990

Parental rearing behaviour, family atmosphere and adult depression: a pilot study with psychiatric inpatients.

In a sample of 72 depressed inpatients the relationships between severity of depression, emotional family atmosphere and perceived parental rearing were studied at admission, discharge and follow-up. The results indicate that paternal rejection and overprotection might be of particular importance for developing social skills used to form close relationships, whereas maternal emotional warmth seems to have a preventive effect by promoting emotional stability.

Child↗
PubMed1990

Influence of pretreatment on interstitial and intracellular space of canine left-ventricular myocardium.

In this study, the interstitial space and myocytes were investigated qualitatively and morphometrically in samples from beating, fibrillating as well as from cardioplegically HTK-arrested hearts fixed by immersion or perfusion. The size of tissue clefts separating bundles of myocytes and that of the interstitial space within bundles of myocytes depend on the functional state and on the kind of fixation. Cellular preservation is significantly better in HTK-arrested hearts compared to beating or fibrillating hearts. Thus, for the structural evaluation of myocytes and interstitium, the pretreatment constitutes a highly significant factor.

Animals↗
PubMed1990

[Not Available].

Explore the source record for details and available documents.

Academies and Institutes↗
PubMed1990

[The EMBU project--a multinational study of the importance of parental child rearing behavior for the development of psychopathologic phenomena].

The influence of childhood experience on psychological development is discussed from various scientific viewpoints. Against this background, the origin of the cross-cultural, multinational EMBU Project on the relationship between upbringing in the family and psychopathology is described. It becomes obvious that a systematic, cross-cultural, and theory-orientated approach can bring significant material for the development of psychiatric theory.

Child↗
PubMed1990

Glycogen effects on energy state and passive electric properties of liver during protection.

In order to evaluate the importance of glycogen for the hepatic tolerance to ischemia, livers of swine fed a glucose-potassium solution for premedication were perfused with either Bretschneider's HTK-solution (histidine-tryptophan-ketoglutarate) or with Euro-Collins-solution (EC) prior to subsequent ischemia at 25 and 5 degrees C. During ischemia, in regular intervals or continuously, energy rich phosphates, lactate, intrahepatic pH and the electrical impedance of liver tissue were determined. The results were compared with corresponding data from swine which had starved for 48 h. Corresponding to the higher glycogen content, energy supply during ischemia was markedly improved by the premedication. Despite high amounts of glucose in the EC-solution, energy supply after glucose-potassium premedication was no better with EC-solution than with HTK-solution. Moreover, glucose uptake led to concomitant cellular water uptake. Electrical impedance measurements during ischemia mirrored improved energetical protection by the glucose-potassium premedication.

Acid-Base Equilibrium↗
PubMed1990

[The effect of chronic exposure to lead on lysosomal levels in amniotic fluid in an experimental model].

Groups of female rats were exposed for prolonged periods to different lead concentrations in drinking water; in one group was also added to the drinking water, in the amniotic fluid of exposed females greatly reduced lysozyme values were found, as compared with controls. Concurrent Zn administration considerably reduced the effect of lead. Long-term exposure to low concentrations of lead caused a greater drop of lysozyme levels in amniotic fluid than that found in previous experiments after short-term exposure to higher lead concentration.

Amniotic Fluid↗
PubMed1990

[Results of long-term studies of the development of children in Goerlitz in the last 3 decades].

The author reports on the results of investigations concerning the development of 15173 girls born in Görlitz between 1944 and 1973. With regard to maturation a significant tendency toward deceleration has been observed. Late menarche is increasing, while early menarche is decreasing. Seasonal influences on the development are discussed. September born girls, for example, are characteristic for a high menarcheal age, those born in December for a low menarcheal age. Furthermore one can assume some relations between the month of birth and the birthweight.

Adolescent↗
PubMed1990

[The radiotherapy of primary extranodal non-Hodgkin's lymphoma of the nasopharynx].

Primary non-Hodgkin's lymphoma occurs quite seldom in the nasopharynx, therefore reports on this topic are rare in medical literature. The treatment results of 30 irradiated patients (40 to 60 Gy) are presented. The period of the study ranges from 1960 to 1985. 13 patients with low grade lymphoma and 17 patients with high grade lymphoma according to the Kiel classification form the basis of this study. The overall actuarial 5-year survival rate is 24%. This also applies for the subgroups of low grade and high grade lymphomas with a 5-year survival rate of 24%, respectively. The evaluation of the patients without generalization in the course of disease shows that the prognosis of stage IE patients with 43% was superior to the one of stage IIE patients with 25% (p less than 0.001). Only patients with lymphoma limited to the nasopharynx survived longer than five years (46%), but none of the patients with simultaneous spread to the nasal cavity, the oropharynx and/or the base of the skull. Local and regional recurrences were rare. However, a generalization of the disease occurred more often (20%), mainly due to insufficient staging in former years. Long-term sequelae of the radiation therapy like rhinitis or pharyngitis sicca were registered occasionally. At present, locoregional radiation therapy is recommended for stage IE and IIE low grade lymphomas and stage IE high grade lymphomas of the nasopharynx.

Aged↗
PubMed1990

The monoptychic glands of the jugulo-sternal scent gland field of Tupaia: a TEM and SEM study.

The monoptychic 'apocrine' scent glands of the sternal region of two adult male Tupaia belangeri were studied by transmission and scanning electron microscopy, in order to assess the modes of release of their secretory products. In segments of the secretory tubules with a narrow lumen the epithelial cells are columnar and are firmly connected to each other by desmosomes and junctional complexes. Myoepithelial cells are interspersed between the secretory epithelium and the basement membrane. The cytoplasm of the secretory epithelial cells contains granular and agranular endoplasmic reticulum, mitochondria, Golgi apparatus, lysosomes and secretory granules. The free surface of the secretory epithelium is furnished with densely arranged microvilli. The apices of the cells protrude as dome-shaped extensions into the glandular lumen. At the tip of these extensions cellular processes of irregular shape are found. The surface of these processes shows no microvilli. They contain densely packed and dilated cisternae of agranular endoplasmic reticulum and free ribosomes. The constriction of the base of these processes and the occasional observation of a 'demarcation membrane' between a process and the secretory cell indicate that these secretory processes become detached from the secretory cells according to the apocrine mode of extrusion. Within the glandular lumen they break down and form secretion. Parallel to this apocrine extrusion the same cells produce secretory granules, the diameter of which measures 300-900 nm. The contents of these granules are released into the glandular lumen by exocytosis according to the eccrine mode of secretion. This resembles the situation in other mammals in which monoptychic glands release their secretory products by means of both apocrine and eccrine extrusion. Therefore monoptychic skin glands should not be classified into apocrine and eccrine glands. Our results corroborate Schaffer's (1927, 1940) more general classification of exocrine glands according to the nature of the secretory epithelium into monoptychic and polyptychic glands.

Animals↗
PubMed1990

[Does the month of birth affect human biological development processes?].

The results of longitudinal investigations of 1,294 girls born in Görlitz in the years 1968 to 1970 included the correlation of their birth weights and menarcheal age with their months of birth. In the process we found very interesting patterns of seasonal distribution. Girls born in January had the lowest, those born in February the highest birth weight on average. Girls born in August reached their menarche at least 4 months later than those born in October. It is conceivable that the season of birth may be much more important to human development than is generally supposed.

Adolescent↗
PubMed1990

[Age on starting school and school achievement].

According to a medical check-up on the whole group of school beginners for one year in the town of Görlitz and considering the results of their first school year, the authors observed that the age on starting school has a very important influence on school achievement. While girls are better able to compensate for developmental retardation, it is advisable to postpone the admission of very young boys for one year in doubtful cases or to provide individual coaching.

Achievement↗
PubMed1990

[Long-term clinical follow-up after coronary dilatation].

To determine the long-term clinical course after percutaneous transluminal coronary angioplasty (PTCA), 841 patients, 615 with successful PTCA and 226 without, were restudied by questionnaire 2-9 years after the intervention. After successful PTCA a lasting symptomatic improvement was seen in 78% of patients vs 55% of patients without successful PTCA (p less than 0.0001). The probability of myocardial infarction 8 years after successful PTCA was 6% vs 24% after unsuccessful PTCA (p less than 0.0005). The 8-year survival probability (non-cardiac deaths excluded) was 95.7% in patients with demonstrable PTCA success, and 92.0% in patients without (p less than 0.05). Similar significant differences in favor of patients with successful PTCA were seen in the long-term prognosis of patients with single-vessel disease (n = 580). It is concluded that a long-term improvement of the cardiac prognosis by successful PTCA is probable.

Angioplasty, Balloon, Coronary↗
PubMed1989

Effect of tumor necrosis factor and granulocyte/macrophage colony-stimulating factor on neutrophil degranulation.

Both TNF and and granulocyte/macrophage CSF (GM-CSF) can activate neutrophils. The aim of this work was to determine the effect of these cytokines on neutrophil degranulation. The secretion of lactoferrin of secondary granules and myeloperoxidase (MPO) of primary granules from single adherent human neutrophils was assayed by use of a reverse hemolytic plaque assay. Both rTNF and rGM-CSF caused secretion of lactoferrin in a dose-dependent manner. Both agents also caused secretion of MPO, but only in the presence of cytochalasin B. Preincubation with pertussis toxin inhibited rGM-CSF-induced secretion of both lactoferrin and MPO. rTNF-induced MPO secretion was also blocked by pertussis toxin, whereas lactoferrin secretion was only slightly affected. Neither rTNF nor rGM-CSF caused any detectable changes in the concentration of cytoplasmic free Ca2+ in fura-2-loaded cells. However, when neutrophils were loaded with increasing concentrations of quin-2 to buffer any local, not detectable, changes in the concentration of cytoplasmic Ca2+, both rTNF- and rGM-CSF-induced secretion of lactoferrin and MPO were almost totally abolished at a relatively low quin-2 concentration. These results suggest a role of a regulatory G-protein and minute local changes in the concentration of cytoplasmic Ca2+ in TNF- and GM-CSF-induced neutrophil degranulation.

Buffers↗