The general practitioner and the Oncology Organization.
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Biomedical subjects
Publications and source records attributed to J Richmond.
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Virus-like particles have been seen on electronmicroscopic examination of four spleens surgically removed for haematological disorders-three cases of idiopathic thrombocytopenic purpura and one case of haemolytic anaemia. The particles were approximately spherical and 50-60 nanometres in diameter.
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Platelet survival has been measured in 16 patients with idiopathic thrombocytopenic purpura. Of this group, three patients had a normal result and surface counting did not show high splenic uptake. The clinical features of these patients are described. These patients have remained well for several years without treatment.
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Coagulation studies were carried out on 30 patients with chronic liver disease. The clotting defect was complex and involved factors V, VII, IX (Christmas factor), and prothrombin. Some patients showed a significant depression of factor IX in the presence of a normal one-stage prothrombin time. Thrombotest was found to be a good indicator of factor IX deficiency in this group of patients and may be of use as an additional liver function test. The screening of patients with liver disease for surgery or liver biopsy should assess the coagulation factors involved in both intrinsic and extrinsic thromboplastin generation.
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