Neurotransmitters and their role in pulmonary physiology.
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Biomedical subjects
Publications and source records attributed to J Richardson.
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Large daily doses of vitamin C maintained high levels of corticosteroids in the blood of stressed mice. Of these corticosteroids, glucocorticoid is known to suppress the immune response. It is hypothesized that large doses of vitamin C may reduce the organism's immunity to disease when stress is present.
Continuous, low-dose, intra-arterial streptokinase was used to treat six patients with ischemia of the hand secondary to distal arterial occlusion. A bolus dose of 100,000 U of streptokinase was administered, followed by a maintenance dose of 5000 U/hr, which was titrated against the patients' coagulation profile. The duration of infusion ranged from 16 to 96 hours. Recanalization was achieved in four patients who were treated within 36 hours of the onset of occlusion.
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Several research studies document the stress of residency training and suggest that support groups may provide house officers with opportunities to release tension, and to attend to their feelings about their experiences. In planning such groups, consideration should be given to the need for this kind of program, its organization, and the means by which it can be evaluated.
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The effects of stress on the central nervous system, endocrine balance and immunity were observed in male Sprague-Dawley rats. Food and water were supplied in unlimited quantities. Extraneous odors were kept away from the control room by an exhaust fan in the adjacent room. At 70 days, experimentation occured for 20 days. In the aspirin, parathroid, serotonin, and pineal groups, there was no significant difference between the undistrubed control and experimental groups. A significant reduction in both the pituitary and adrenal weights was seen in the melatonin experimental group and the undisturbed control group. The placebo control group showed a significant increase in both the pituitary and adrenal gland weights. Stress was blocked in the groups receiving aspirin, parathroid, serotonin, and pineal preparations. The melatonin group, however, very significantly blocked the stress in that both the pituitary and adrenal weights were significantly below the undisturbed control group. The aspirin blocked stress by inhibiting synthesis of prostaglandins. Melatonin works through the pituitary-adrenal axis to reduce adrenal secretion.
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A brief survey is given of the eye movement parameters which contribute to visual search strategies. The literature on eye movements and industrial inspection is reviewed and some recent studies carried out at the University of Birmingham into the eye movements underlying four inspection tasks are described. These tasks included the inspection of tin cans, electrical edge connectors, men's briefs and woven fabric.
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