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Biomedical subjects

J Reynaud

Publications and source records attributed to J Reynaud.

At least 37 records · Page 2Linked to original sources
PubMed1991

A case of myelodysplastic syndrome with abnormal megakaryocytes and ins(8;3)(q24;q21q26).

We report a 56-year-old male patient with refractory anemia with excess of blasts in transformation (RAEB-T) who had an ins(8;3)(q24;q21q26) as the sole chromosome abnormality in bone marrow (BM) cells. The findings of disturbed thrombocytopoiesis with numerous micromegakaryocytes suggest that it could be a variant of the classic ins(3;3)(q26;q21q26) described in hematologic malignancies with abnormal thrombopoiesis.

Bone Marrow↗
PubMed1991

Hydroxyurea versus interferon alfa-2b in chronic myelogenous leukaemia: preliminary results of an open French multicentre randomized study.

In order to compare the effects of interferon versus hydroxyurea for the treatment of chronic myelogenous leukaemia (CML), 58 CML patients, having received no previous treatment, were randomized into two treatment groups (hydroxyurea or interferon) for an open multicentre study from 1 May 1987 until 1 July 1990. Fifty patients were evaluable: 24 in the interferon group and 26 in the hydroxyurea group. Haematological response was obtained in 16/24 interferon-treated patients and 23/26 hydroxyurea patients. Failure to obtain haematological remissions occurred in eight of 24 interferon-treated patients and in three of 26 hydroxyurea patients. Four interferon-treated patient failures and one hydroxyurea-treated failure were due to drug intolerance. Progression occurred in one interferon-treated patient and in three patients given hydroxyurea. Fourteen of 16 patients in the interferon group and 17/23 in the hydroxyurea group continue on study and show no progression.

Adult↗
PubMed1991

[Alexander's disease].

Alexander disease, or hypoproconvertinemia is a rare autosomic recessive coagulation disorder. The features include familial and/or personal history of bleeding, with an abnormal prothrombin period and a normal activated partial thromboplastin period. Coagulation and genetic studies allow subclassification with prognosis incidence for this disease. The authors report on a case of one family with Alexander disease.

Child↗
PubMed1989

A complex t(3;8;17) involving breakpoint 8p11 in a case of M5 acute nonlymphocytic leukemia with erythrophagocytosis.

The t(8;16)(p11;p13) is a recently described new chromosome rearrangement of acute nonlymphocytic leukemia (ANLL). It appears to be specifically associated with acute monoblastic (AML-M5) or unusual myelomonocytic leukemia with prominent erythrophagocytosis in the leukemic cells. A complex t(3;8;17)(q27;p11;q12) is reported in a case of acute monoblastic leukemia with erythrophagocytosis. Sixteen cases of this t(8;16) and two other variant translocations are reviewed. The pathogenetic mechanism of the variant translocations is discussed, suggesting that the der(8) is a consistent recombinant.

Chromosome Banding↗
PubMed1989

Molecular diagnosis of chronic myeloid leukemia using a 3'bcr probe.

Chronic myeloid leukemia (CML) is characterized by the Philadelphia chromosome which results from a reciprocal (9; 22) translocation, with the protooncogene c-abl moving from chromosome 9 to 22 and juxtaposed to the proximal bcr. Breakpoints on chromosome 22 are localized within 5.8 kb of the breakpoint cluster region (bcr). We have assessed the feasibility of using a 3'bcr probe for molecular diagnosis of CML. Thirty patients with Ph chromosome negative or positive CML were studied by Southern blot. A bcr rearrangement was seen to be present in all but one patient with Ph+CML. A case of Ph negative CML showed a bcr rearrangement. We conclude that this technique is efficient for molecular diagnosis of CML.

Blotting, Southern↗
PubMed1984

[Generalized peritonitis of non-traumatic colonic origin. Reflexions on 62 cases].

The authors analyze sixty-two cases of acute generalized peritonitis with a non-traumatic colonic etiology. They point out that the prognosis depends on three main factors: the age of the patient, the time spent in diagnosis and the therapeutic difficulties. They recommend a gastrographin colonic enema to obtain earlier diagnosis, in the absence of radiological evidence of pneumoperitoneum, in elderly patients presenting with abdominal signs. They also recommend multistage surgical management combining effective drainage of the abdominal cavity with resection of the perforated segment of the colon, whenever there is extensive damage to the colon, or in the presence of a tumor. In their view, conservative surgery should be confined to strictly selected cases not involving tissue resection. These indications are essential if a satisfactory result is to be achieved.

Adult↗
PubMed1984

[Cholesteatoma of the external auditory canal].

Epidermal plugs of the external auditory canal were described initially by Toynbe in 1850, and since that time epidermal plugs and canal cholesteatomas have often been classified under the same heading. However, auditory canal cholesteatoma represents a separate clinical entity, although its pathogenicity remains unrecognized. Therapy may be medical or surgical, but a more eclectic therapeutic approach is to be preferred. Two recent cases of auditory canal cholesteatoma are reported.

Aged↗
PubMed1984

[Auditory-evoked brainstem potentials and stapedius muscle reflex: intersubject variability].

Like other workers, we found gender differences in auditory-evoked brainstem response latencies. For the time being, this intersubject variability remains unexplained. This difference was observed only for wave V latency, and delta I-V is longer in men than in women, whereas delta I-III is identical. The absence of functional differences in the lower portion of the auditory tract is confirmed by both auditory-evoked brainstem potentials and stapedius reflex latency. Wave V latency and the influence of technical and anatomical factors are discussed as well.

Acoustic Impedance Tests↗
PubMed1984

[Pancreatitis: a little-known cause of ureteral obstruction].

Left ureteral stenosis induced by pancreatitis was observed in one case. Five similar cases have been reported in the literature. Ureteral obstructions may be found in two clinical contexts--patent pancreatitis or retroperitoneal fibrosis. The ureter may be simply compressed mechanically, or there may also be enzymatic or ischemic necrosis. The clinical approach should be directed towards treating primarily the pancreatitis and secondarily the urological pathology. As regards the urological treatment, ureterolysis or ilio-ureteroplasty are indicated in cases of organized irreversible ureteral stenosis.

Adult↗
PubMed1983

Auditory brain stem responses and cortical auditory-evoked potentials in difficult-to-test children.

Brain-stem-evoked responses (BERs) and cortical auditory-evoked potentials (AEP) were recorded in 24 children showing severe behavioral disorders. BER testing always requires sedation if not general anesthesia. This allowed us to perform precise acoustic impedance measurements, and thus to find 3 glue ears. The electrophysiological tests revealed whether there was sensorineural deafness, which was cared for if necessary. Finally, when the BERs were normal, we evaluated the modifications in the cortical AEP, in relation to a clinical classification closely related to that of the DSM III of the American Academy of Psychiatry.

Adolescent↗
PubMed1982

[Clinical manifestations of various mycoses of the upper respiratory and digestive tracts in African pathology].

Mycotic infections are prevalent in tropical Africa, and are sometimes observed North and South of this zone, but they are usually localized to the lower limbs (mycetoma), without manifestations in the ORL sphere. However, various ubiquitous superficial mycoses are also encountered in Africa, particularly Aspergilloses and Candidoses. Their clinical expression (apart from several cases of pseudo-tumoral sinusal aspergillosis...) differs only slightly from that observed and treated everywhere, and they are not discussed. Also excluded are several cases of North-American Blastomycosis reported North and South of the Sahara (Blastomyces Dermatidis). Their ORL manifestations do not appear to have been studied. Three very well known major forms remain: Histoplasmoses, Rhinosporidiosis, Phycomycoses (or Rhino--Entomophtoroses). Sporotrichoses with nasofacial manifestations may also, perhaps, be included.

Adolescent↗