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Biomedical subjects

J Revuz

Publications and source records attributed to J Revuz.

At least 343 records · Page 19Linked to original sources
PubMed1983

[Role of corticoid-antibiotic combinations in local treatments. Critical study].

Current literature about steroid antibiotic combinations has been critically reviewed. The use of such combinations may be considered in infected steroid sensitive dermatosis. Definition of super-infection is however impossible on clinical data only. A single study demonstrated the superiority of the combination upon the steroid alone in well defined experimental conditions. This superiority is not demonstrated beyond 8 days of treatment or in case of pretreatment with local antiseptic solutions or baths. Theoretical side effects of local antibiotics include, sensitization, selection of antibiotic resistant germs, systemic toxicity. They are not troublesome in current practice. However adjunctions of an antibiotic can diminish the steroid efficacy when infection is not present. The real usefulness of the combination in current practice is still to be demonstrated.

Administration, Topical↗
PubMed1983

[Treatment of herpes zoster].

A critical study of therapeutic trial reports on herpes zoster is presented. It is noteworthy that authors are frequently unaware of the natural history of herpes zoster; therapeutic trials are not always correctly designed; misinterpretation of the data is not unfrequent. Proof of efficacy is missing for several commonly used drugs. Two groups of drug seem promising: -- Modern antiviral nucleoside analogues : Acyclovir, Vidarabine, Bromovinyl-desoxyuridine are probably effective for severe herpes zoster in immunocompromized patients. -Systemic adrenal steroids are effective as a prevention of post-herpetic neuralgia in elderly patients. The real usefulness of these two treatment procedures, as a whole and for individual patient, remains to be established by well-designed controlled trials. Other treatments should be surrended.

Adrenal Cortex Hormones↗
PubMed1983

[Facial lupus vulgaris caused by BCG].

The authors report on an exceptional complication of BCG vaccination: a case of facial lupus vulgaris, which appeared one year after vaccination in a girl with normal cellular and humoral immunity.

Antibiotics, Antitubercular↗
PubMed1983

Plasma exchange in pemphigus. Uncontrolled study of ten patients.

Plasma exchange, together with oral immunosuppressive drugs and various doses of adrenal steroids, were used in the treatment of ten patients with pemphigus. Initially plasma exchange decreased the intercellular antibody (IC Ab) level in all patients and induced a clinical improvement in the conditions of eight of ten patients. This improvement was sustained for the six patients who received simultaneously 0.5 mg/kg/day or more of prednisone. Among the eight patients, four previously corticoresistant patients had perfect control of their disease. Conversely the other four patients, treated with low doses of prednisone, experienced a posttreatment rebound in IC Ab level and showed no or only transient clinical improvement. Plasma exchange may be useful in bringing corticoresistant pemphigus under control but it is not to be used without accompanying high doses of adrenal steroids.

Aged↗
PubMed1983

[Hematologic anomalies in Lyell's syndrome. Study of 26 cases].

Case records of 26 patients with Lyell Syndrome were reviewed for studying haematologic abnormalities. Eosinophilia, neutropenia, thrombopenia were uncommon. Circulating immature granulocytic cells were frequently encountered during the second week of evolution, mostly when leucocytosis was present. Anemia was frequent, the lowest haemoglobin titer beeing reached by the 15th day. Reticulocytosis was initially low and reached a peak during the second week. At that time biological markers of inflammatory syndrome were getting worse. So the originating anemia seems primarily of medullary origin and independent of inflammatory syndrome. Lymphopenia was constant and sometimes marked, with no circulating lymphocytes in two cases. The lowest numbers of lymphocytes were observed during the first week. These haematological abnormalities may have some pathogenic significance.

Anemia↗
PubMed1982

[Methemoglobinemia and hemolytic anemia induced by Disulon].

Seven patients ingested (2.5 mg/kg) daily dapsone. Their serum samples were analyzed daily during the first week by spectrophotometry for methaemoglobinemia and weekly blood samples for red blood cells, reticulocytes count and haptoglobin level. The acetylator phenotype of each patient was estimated on the capacity to acetylate isoniazid. Methaemoglobinemia was always observed within the 48 hours after drug intake. The dapsone induced anemia was moderate being maximum between day 25 and 40 after the beginning of treatment. Reticulocytemia appeared in the second week and haptoglobin levels decreased between day 5 and 8 of therapy in 5 patients and at day 15 for the two others. The seven patients are divided in 4 rapid acetylator and 3 slow acetylator. The acetylator phenotype was not correlated with methaemoglobin, haptoglobin levels or RBC counts.

Acetylation↗