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Biomedical subjects

J Reid

Publications and source records attributed to J Reid.

At least 91 records · Page 5Linked to original sources

Administration to innovation: the evolving management challenge in primary care.

The concept of the primary health-care team involving an increasingly diverse range of health care professionals is widely recognized as central to the pursuit of a primary care-led health service in the UK. Although GPs are formally recognized as the team leaders, there is little by way of policy prescription as to how team roles and relationships should be developed, or evidence as to how their roles have in fact evolved. Thus the notion of the primary health-care team while commonly employed, is in reality lacking definition with the current contribution of practice managers to the operation of this team being poorly understood. Focusing on the career backgrounds of practice managers, their range of responsibilities, and their involvement in innovation in general practice, presents a preliminary account of a chief scientist office-funded project examining the role being played by practice managers in primary health-care innovation. More specifically, utilizing data gained from the ongoing study, contextualizes the role played by practice managers in the primary health-care team. By exploring the business environment surrounding the NHS general practice, the research seeks to understand the evolving world of the practice manager. Drawing on questionnaire data, reinforced by qualitative data from the current interview phase, describes the role played by practice managers in differing practice contexts. This facilitates a discussion of a set of ideal type general practice organizational and managerial structures. Discusses the relationships and skills required by practice managers in each of these organizational types with reference to data gathered to date in the research.

Community Health Services↗

Can audit of a local protocol for the management of lipid disorders effect and detect a change in clinical practice?

OBJECTIVE: To audit the implementation of a local protocol for the management of lipid disorders in Grampian. INTERVENTION: A local protocol for the detection and management of lipid disorders, developed by a multi-disciplinary group and based on available national guidelines and systematic reviews, was disseminated and implemented using the audit cycle. DESIGN: An uncontrolled before and after study using four surveys of different aspects of lipid management in primary and secondary care. RESULTS: There was evidence of change in clinical practice following protocol implementation. Improvements in patient care were identified. However, some areas of inappropriate practice remained unaltered. Changes in dietary therapy indicated an improvement in the appreciation of the importance of appropriate dietary advice. There was an increase in the proportion of patients who were appropriately screened and managed, and appropriately referred to the lipid clinic. The health status of patients being screened/treated following guidelines was poorer suggesting a reduction in screening of low risk patients and an increase in lipid assessment of patients with other health problems or risk factors i.e. more appropriate screening. However, after the protocol was disseminated, general practitioners screened less often for secondary causes of hyperlipidaemia.

Aged↗

A community trial of a written self management plan for children with asthma. Asthma Foundation of NZ Children's Action.

AIMS: To determine the effect of introducing an action plan to children with mild to moderate asthma, who have never used a plan before. METHODS: Children were recruited from general practitioner records with a diagnosis of asthma, and who agreed to participate, having identified that they had not used an action plan before and that they had mild or moderate asthma based upon symptoms, acute episodes and the need for preventative medication. The families were given a plan, and its use was explained to them by their general practitioner. A symptom diary was kept, and, where appropriate, peak flow measurements were recorded. A number of outcomes were measured to determine changes that could be attributed to the introduction of the plan. RESULTS: Following the introduction of the plan, the percentage of nights woken for asthma fell from 18.2% to 12.2% (P<0.001) and the number of days out of action fell from 6.4 to 4.1 (P<0.001). The requirement for acute medical treatment also fell during the intervention period with general practitioner visits falling from 129 to 42 (p<0.001). Most participants commented favourably about the usefulness of the plan in giving them a better idea of the state of their asthma at any time, and in knowing what to do about it. CONCLUSIONS: The children's action plan, when introduced into a group of asthmatic children was effective and acceptable in the self management of asthma.

Asthma↗

Pharmacokinetics of propofol infusions, either alone or with ketamine, in sheep premedicated with acepromazine and papaveretum.

The pharmacokinetics of propofol were investigated in two groups of five Scottish blackface sheep undergoing surgery for the implantation of subcutaneous tissue pouches. After premedication with acepromazine and papaveretum, anaesthesia was induced with either propofol at 4 mg kg-1 intravenously (group 1) or with a mixture of propofol at 3 mg kg-1 and ketamine at 1 mg kg-1 intravenously (group 2). Anaesthesia was maintained with a variable infusion rate of either propofol alone (group 1) or propofol and ketamine (group 2). Both regimens produced satisfactory conditions for superficial surgery of the body surface. The mean (SD) duration of anaesthesia was 64.8 (3.1) minutes for group 1 and 60 (0) minutes for group 2; the mean total dose of propofol given to the sheep in group 1 was 801 (84) mg, and the sheep in group 2 received 470 (46) mg of propofol and 267 (30) mg of ketamine. The mean elimination half-life of propofol was 56.6 (13.1) minutes in group 1 and 50.3 (21.4) minutes in group 2; the mean volume of distribution at steady state was 1.037 (0.480) litre kg-1 in group 1 and 1.515 (0.939) litre kg-1 in group 2; the mean body clearance was 85.4 (28.0) ml kg-1 min-1 in group 1 and 128.0 (35.0) ml kg-1 min-1 in group 2; the mean residence time corrected for a bolus injection was 12.1 (4.2) minutes in group 1 and 11.9 (6.6) minutes in group 2; for the infusion, the mean residence time was 72.1 (4.2) minutes in group 1 and 69.9 (7.9) minutes in group 2. There were wide variations in the blood propofol concentrations reached in individual sheep by using this standard dosing regimen. All the sheep recovered quickly from anaesthesia; the mean times to extubation, sternal recumbency and standing for the animals in group 1 were 2.8 (0.4), 6.3 (1.2) and 10.9 (1.6) minutes from the end of the infusion, and the times for group 2 were 5.3 (0.9), 11.2 (1.7) and 15.1 (2.2) minutes.

Acepromazine↗

Simultaneous infusions of propofol and ketamine in ponies premedicated with detomidine: a pharmacokinetic study.

The pharmacokinetics of propofol and ketamine administered together by infusion were investigated in four ponies. Blood propofol and plasma ketamine and norketamine concentrations were measured by high performance liquid chromatography. After premedication with detomidine (20 micrograms kg-1) anaesthesia was induced with ketamine (2.2 mg kg-1 intravenously). The trachea was intubated and the ponies were allowed to breathe 100 per cent oxygen. A bolus dose of propofol (0.5 mg kg-1) was then administered intravenously and propofol and ketamine were infused for 60 and 45 minutes, respectively. The average mean infusion rate of propofol was 0.136 mg kg-1 min-1, and the ketamine infusion rate was maintained at 50 micrograms kg-1 min-1. The mean (SD) elimination half-lives of propofol and ketamine were 69.0 (8.0) and 89.8 (26.7) minutes, the mean volumes of distribution at steady state were 0.894 (0.161) litre kg-1 and 1.432 (0.324) litre kg-1; the mean body clearances were 33.1 (4.5) and 23.9 (3.8) ml kg-1 min-1 and the mean residence times for the infusion were 87.1 (4.1) and 110.7 (8.2) minutes, respectively. Norketamine, the main metabolite of ketamine, was detected throughout the sampling period. The mean residence time for norketamine was 144 (16) minutes. All the ponies recovered quickly from the anaesthesia; the mean times to sternal recumbency and standing were 11.1 (5.3) and 30.0 (20.8) minutes, respectively, from the end of the infusion.

Anesthetics, Dissociative↗

Pharmacokinetics of propofol as an induction agent in geriatric dogs.

The pharmacokinetics of propofol were investigated in six unpremedicated dogs aged between eight-and-a-half and 10.5 years. After the induction of anaesthesia with a bolus dose of 5 mg kg-1 propofol administered intravenously, the trachea was intubated and anaesthesia was maintained with halothane in a gas mixture of oxygen and nitrous oxide. The mean (sd) t1/2 beta was 83.9 (14.8) minutes, the mean (SD) residence time was 99.0 (10.8) minutes, the mean body clearance was 34.5 (12.1) ml kg-1 minute-1 and the mean volume of distribution at steady state was 3864 (1647) ml kg-1. The dose of propofol was lower than that recommended in the data sheet (6.5 mg kg-1) and was associated in some of these dogs over eight years of age with post-induction apnoea. The clearance of propofol was also slower than that previously reported in young dogs. These results have implications for infusion rates when propofol is used to maintain anaesthesia in dogs.

Aging↗

Effect of a single injection of a long-acting gonadotropin-releasing hormone agonist on prepubertal male and female pigs on reproductive organs, growth performance and sensory qualities of pork roasts.

Crossbred pigs (n = 200) were used to study the effects of a long-acting form of gonadotropin-releasing hormone (GnRH) agonist on the reproductive systems of male and female pigs and their growth performance and sensory quality of pork roast. Treatment was a single injection of a controlled release formulation of GnRH agonist [D-Trp6, des-Gly10]-GnRH ethylamide to release 5 micrograms/(kg x day) for 4 months beginning when the pigs were 66 +/- 2 days old. Pigs were allocated to five groups of 40 animals each: males castrated (CM) at 13 +/- 2 days, intact males (IM), treated males (TM), intact females (IF) and treated females (TF). Ovarian and uterine weights at slaughter averaged 3.67 and 79.8 g, respectively, in IF compared with 1.38 and 26.5 g in TF (P < 0.05). Testicular weights were 203 g in IM and 36.8 g in TM (P < 0.05). Microscopic observations of the testes revealed an absence of sperm cells but the presence of germ cells. Steroid concentrations at slaughter from all pigs showed that intact males had significantly more testosterone in their serum (26.36 +/- 9.87 nmol/L) compared with TM, CM, IF or TF groups and that treated males had intermediate concentrations (12.50 +/- 7.44 nmol/L) higher (P < 0.05) than those in CM and TF. Administration of GnRH agonist during the growth period of male pigs had no consistent effect on growth performance, but as compared to IM pigs, some of the carcass characteristics such as meat ratio (49.1 vs 50.2% in TM and IM; P < 0.001), dressing percentage (77.5 vs 76.5% in TM and IM; P < 0.05) and average backfat (20.8 vs 17.6 mm in TM and IM; P < 0.05) were modified by such a treatment. Meat quality, however, as determined by flavor and tenderness evaluations by sensory panelists, were similar (P < 0.05) in all groups and off-flavor scores were lower in TM than in IM (P < 0.001). As for males, backfat and meat ratio were different in TF compared to IF (P < 0.05) and roast juiciness was higher in TF than IF (P < 0.05). These results suggest that GnRH agonist can reduce gonadal secretory activity to castration levels during the growth period of prepubertal male pigs and could be an alternative to surgical castration in the pork industry with no negative effects on growth and meat quality. No advantage to endocrine castration in females was found.

Animals↗

Airway problems after carotid endarterectomy.

Respiratory obstruction has been reported as a complication of carotid endarterectomy; the causes include traumatic mucosal oedema, direct tracheal compression by haematoma and oedema secondary to lymphatic and venous congestion. We report four cases of acute respiratory obstruction complicating carotid endarterectomy. Two of these cases suffered respiratory arrest in the postoperative ward and required emergency tracheal intubation in difficult circumstances. All of these patients had developed wound haematomas and all required surgical intervention.

Aged↗

Developing a local protocol for the management of lipid disorders in general practice.

Guidelines and protocols are increasingly becoming part of routine clinical practice. A standardised methodology has been proposed for the development of national guidelines based on principles which are known to effect validity. However, less is known about the most appropriate methodology for the development of local protocols. A case study is presented of the development of a local protocol for the management of lipid disorders in primary care in Grampian. It highlights the practicalities of such a process and identifies lessons for others who may wish to develop local protocols.

Clinical Protocols↗

Stress management. Does it work?

This article describes an approach to stress management using a case history format. Stress management is a method of helping that is useful both as an approach to overall patient management and as a desirable option for the practitioner. It is an effective way of involving people more in their own care and deserves much wider attention by practitioners.

Humans↗

Assessment and diagnosis of attention deficit/hyperactivity disorder in pediatric general practice.

Thorough assessment is a critical first step in the treatment of any psychiatric disorder. The need for rigorous assessment procedures is underscored for those disorders, such as Attention Deficit/Hyperactivity Disorder (ADHD) of childhood, that have a high comorbidity with other common psychiatric disorders, including childhood depression and anxiety. Extensive research regarding diagnostic procedures for ADHD has demonstrated the importance of obtaining assessment data from multiple informants and in multiple modalities as a way of confirming ADHD diagnoses. This article describes how a physician in general pediatric practice might execute a thorough initial and follow-up assessment of a child's ADHD symptomology.

Antidepressive Agents, Tricyclic↗