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Biomedical subjects

J Rees

Publications and source records attributed to J Rees.

At least 127 records · Page 7Linked to original sources
PubMed1985

The value of the measurement of cerebrospinal fluid levels of lysozyme in the diagnosis of neurological disease.

A turbidimetric technique has been adapted to yield maximum sensitivity for the measurement of lysozyme in cerebrospinal fluid. One hundred and ninety-eight patients were studied over a total period of 9 months using this technique. In addition to the considerably elevated levels known to occur in cases of bacterial and fungal meningitis, increased activity was also demonstrated in cases of subarachnoid haemorrhage and in certain inflammatory conditions. Normal or marginally increased levels were seen in cases of viral meningitis and encephalitis.

Bacterial Infections↗
PubMed1984

Necrosis and sequestration in the tympanic part of the temporal bone.

Unilateral ulceration, bone necrosis, and sequestrum formation in the external auditory meatus are at times confused with the general diagnosis of keratosis obturans. However, the clinical presentation and the radiological and pathological characteristics of this condition are quite distinct from the latter. Initial examination in this situation may raise the suspicion of malignancy. When a true cholesteatoma of the external auditory meatus is found in association with this entity, according to a review of the available literature and personal observation of the authors, it is the result rather than the cause of this pathological process. In order to clarify this relationship, three patients are presented in whom there is radiological and histological evidence of bone necrosis and sequestration of a segment of the temporal bone but no evidence of hyperkeratosis in the ear canal.

Ear Canal↗
PubMed1983

Klippel-Trenaunay syndrome: a review.

The Klippel-Trenaunay syndrome is a triad of congenital anomalies characterized by a vascular nevus, varicose veins and bony and soft-tissue hypertrophy. Although the syndrome is uncommon, initially the condition appears as a skin blemish or varicose veins. To avoid errors in management, it is important to recognize the syndrome. In this paper the authors outline the presentation, investigation and management of Klippel-Trenaunay syndrome and describe four cases of their own. One form of Klippel-Trenaunay syndrome, in which all the anomalies of the triad are important, in which direct signs of a large arteriovenous shunt are present and for which the surgical approach is difficult, is Parkes-Weber syndrome. Lack of reports in the world literature on long-term follow-up leaves many unanswered questions regarding prognosis and management.

Angiomatosis↗
PubMed1982

Intravenous naloxone in acute respiratory failure.

A 58-year-old man presented with acute on chronic respiratory failure. In the acute stage of his illness an infusion of the opiate antagonist naloxone caused an improvement in oxygen saturation as measured by ear oximetry from 74% to 85%, while a saline infusion resulted in a return of oxygen saturation to the original value. When he had recovered from the acute episode the same dose of naloxone had no effect on oxygen saturation. These findings suggest that in acute respiratory failure there may be overproduction of, or increased sensitivity to, endorphins.

Acute Disease↗
PubMed1982

A comparison of the effects of different methods of administration of beta-2-sympathomimetics in patients with asthma.

Double-blind cross-over studies of oral and inhaled terbutaline and salbutamol have been performed in two groups of asthmatic patients. Both drugs at the doses recommended by the manufacturers produced similar maximal effects. The onset of response was faster with inhaled treatment and there was no difference in length of action between the drugs or the routes of administration. Side-effects were much more common with oral treatment. In a separate study oral and inhaled terbutaline were compared in 11 asthmatic patients and this also showed a similar maximal response in tests of forced expiration. A greater response was seen in sGaw following inhaled treatment (P less than 0.05). These results suggest that beta-2-sympathomimetic drugs should be administered by the inhaled in preference to the oral route.

Administration, Oral↗
PubMed1982

Thyrotoxicosis and dyspnoea.

Shortness of breath is a common symptom in thyrotoxicosis and it may have a number of causes. We have studied dyspnoea, skeletal muscle power and respiratory muscle power in eleven patients who had thyrotoxicosis with no evidence of heart failure. Four patients (36.4%) had a marked improvement with treatment in the maximal inspiratory pressure developed at the mouth. All four were breathless and had a proximal myopathy before treatment. This confirms the existence of a group of thyrotoxic patients with a reversible respiratory muscle myopathy which may explain the frequent finding of breathlessness on exertion in such patients.

Adult↗
PubMed1981

Pubertal induction of sweat gland activity.

1. To study the difference in sweat rate between men and women the rates of cholinergic-induced sweating were measured in normal people before and after puberty and in response to androgens and anti-androgens. 2. Sweat rate in men was more than double that in women. 3. This difference did not occur in prepubertal boys and girls in whom the rate, corrected for surface area, was comparable with that in women. 4. Application or injection of androgen locally did not stimulate sweat production in the adult female. 5. Anti-androgen topically or systemically did not decrease sweat rate in men. 6. It is concluded that the rate of sweat rate in men is caused by androgen-induced gene expression at puberty and not by androgen modulation in adult life.

Acne Vulgaris↗