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J Reboul

Publications and source records attributed to J Reboul.

82 records · Page 5Linked to original sources
PubMedDate not supplied

[Determination of anti-DNA and anti-RNA antibodies in serum and CSF by a new counterimmunoelectrophoresis method].

A new quantitative counterimmunoelectrophoresis technique allows the determination of anti-DNA and anti-RNA antibodies in the serum and the unconcentrated CSF. Normal sera (but not normal CSF) presents anti-DNA and anti-RNA antibodies probably of IgG type. Pathological results (elevated serum values and/or presence of anti-nucleic antibodies in CSF) are observed in some neurological diseases especially SSPE, multiple sclerosis and, generally speaking infectious diseases. A very significant correlation exists between the presence of anti-nucleic antibodies in CSF and a local (intrathecal) IgG synthesis. The same correlation is observed with oligoclonal aspect in CSF. In some cases a percentage of anti-nucleic antibodies higher in CSF than in serum may indicate the persistence of an infectious agent inside the central nervous system.

Antibodies, Anti-Idiotypic↗
PubMedDate not supplied

[Interest of clinical classification in prognosis and therapeutics of multiform glioblastomas of adult patients (author's transl)].

Since 1978 we studied the different clinical prognostic factors on the survival of patients with malignant gliomas. The two main clinical factors of survival incidence are age and post-operative neurological status, or after anti-oedema treatment. We have established a clinical classification ; Group I : patients under 50 years with a good neurological status. Group II : Patients with one pejorative factor : age superior to 50 years, or poor neurological status. Group III : patients with two pejorative factors : age superior to 50 years and poor neurological status, or patients above 65 years. Our results confirm such an approach, by the study of 96 patients under a similar treatment. Histological grade may introduce a bias in such a study ; we have therefore studied the 55 patients whose multiform glioblastoma had an histological confirmation. This second analysis confirms the validity of our study, which is then the basis of the therapeutic approach to each group of patients.

Adolescent↗