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J Rapaport

Publications and source records attributed to J Rapaport.

At least 55 records · Page 3Linked to original sources
PubMed1988

Prediction of the risk of hereditary retinoblastoma, using DNA polymorphisms within the retinoblastoma gene.

Using molecular cloning, we earlier isolated the "retinoblastoma gene"; mutations or deletions at this locus are associated with the hereditary predisposition to some human cancers, especially retinoblastoma and osteosarcoma. To develop diagnostic tests for such a predisposition, we identified restriction-fragment-length polymorphisms (RFLPs) within the retinoblastoma gene and tested their usefulness in predicting the risk of cancer in 20 families with members who had hereditary retinoblastoma. We were able to make predictions in 19 of the 20 kindreds. In 18 kindreds, we demonstrated a consistent association of marker RFLPs with the mutation predisposing to retinoblastoma. In the 19th kindred, there may be a lack of cosegregation of the DNA polymorphisms within the gene and the site of the mutation predisposing to retinoblastoma. However, there is uncertainty about the clinical diagnosis of the retinal lesion in a key member of this kindred; if the lesion is not a retinoblastoma, there is no discrepancy between the DNA polymorphisms and the retinoblastoma trait. We conclude that it is feasible and clinically useful to use these DNA polymorphisms to determine the risk of cancer.

Alleles↗
PubMed1988

Neutron scattering cross sections and partial kerma values for oxygen, nitrogen and calcium at 18 less than En less than 60 MeV.

Recent measurements of differential elastic and inelastic neutron scattering from oxygen, nitrogen and calcium at 18 less than En less than 26 MeV are presented and analysed in terms of the optical model. These data, together with earlier measurements of scattering and total cross sections, are used to construct model potentials that may be used to calculate various quantities of interest in neutron dosimetry in an energy region (20-60 MeV) where very few cross section data are available. The heavy-ion-recoil contribution to kerma is obtained directly from the data at each energy. The value of proton inelastic scattering data for validating potential models at high energy is discussed.

Calcium↗
PubMed1987

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Journal Article↗
PubMed1975

Giant keratoacanthoma of the nose.

In a case of giant keratoacanthoma of the nose, the lesion was extremely invasive, destroying the entire nose. Electrosurgical removal of the grossly abnormal tissue was followed by rapid recurrence on two occasions. Radiation therapy was not effective. The lesion healed after the use of bleomycin sulfate.

Adult↗