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Biomedical subjects

J Rajs

Publications and source records attributed to J Rajs.

At least 73 records · Page 4Linked to original sources
PubMed1979

Scintigraphy of induced myocardial infarcts with 99Tcm-gluconate.

A new isotope compound, 99Tcm-gluconate, for detection of myocardial infarction has been tested in dogs. A close correlation was found between the isotope uptake measured in vivo with a gamma camera and the infarct weight of early irreversible myocardial infarcts.

Animals↗
PubMed1979

Histological diagnosis of myocardial injury. Comparison of hematoxylin-basic fuchsin-picric acid (HBFP)-stained sections obtained during autopsy with isolated viable rat cardiac myocytes exposed to anoxia.

The light microscopic appearances in hematoxylin-basic fuchsin-picric acid (HBFP)-stained histological sections from cardiac and skeletal muscle tissue were put in relation to the reactions of isolated viable rat cardiac myocytes exposed to anoxia in suspension and their morphology in paraffin-embedded sections. Special attention was paid to prenecrotic phases of myocytic injury which were followed, in viable rat cardiac myocytes, by light microscopy, and confirmed with biochemical assays indicating increased plasma membrane permeability. In cases of sudden death, and traumatic injury to the heart and skeletal muscle, there was good agreement between alterations demonstrated with the HBFP technique and alterations of viable rat cardiac myocytes exposed to anoxia. In isolated myocytes, these alterations were associated with irregular contractility which, when occurring in situ, might have influenced the cardiac function prior to death. Moreover, the changes develop at a much faster rate than the inflammatory reaction following tissue injury and may therefore be regarded as an early vital phenomenon of significance in clinico-pathological and medico-legal considerations.

Adolescent↗
PubMed1978

Comparison of anoxic changes in isolated rat cardiac myocytes in suspension and in histological sections.

Cardiac myocytes from adult rat were isolated by heart perfusion in the presence of collagenase and incubated in the absence and presence of oxygen. As a result of anoxia, there was a gradual increase in plasma membrane permeability, noted as an increase in succinate-stimulated oxygen uptake, a decrease in trypan blue exclusion frequency, a leakage of cytosolic lactate dehydrogenase activity and an increased proportion of swollen, irregularly contracting myocytes. The contractions of the damaged myocytes resembled the known non-physiologic contractions of the heart, i.e. extrasystoles, arrhythmia, fibrillation or block. After different periods of time of anoxia myocyte pellets were fixed in formalin, sectioned and examined by light microscopy. The appearances of the myocytes in suspension were compared with those in paraffin-embedded sections. Special attention was given to the hematoxylin basic fuchsin picric acid stain and it was noted that the basic fuchsin was taken up by contracted or damaged myocytes, which according to their morphology in suspension revealed irregular contractions, but not by undamaged or necrotic myocytes.

Animals↗
PubMed1977

Spontaneous rupture of a congenital diverticulum of the right ventricle in a 1-month-old child.

Spontaneous rupture of a thin fibrous congenital subepicardial diverticulum of the right ventricle of the heart resulted in a sudden death of an 1-mth-old child. Heart catheterization with angiocardiography at 1 and 2 wk of age revealed a truncus arteriosus type A 1 with a small frontal outbulging in the level with the outflow of the right ventricle, interpreted as a blind infurdibular chamber. At autopsy this outbulging was identified as a congenital fibrous diverticulum of the right ventricle. Death was due to rupture of the diverticulum and hemopericardium. The case motivated a reviewing of the literature dealing with congenital diverticula of the right ventricle of the heart, as well as a discussion of problems with the diagnosis of the diverticulum.

Diverticulum↗
PubMed1976

Aortic aneurysm developing after umbilical artery catheterization.

A variety of complications of umbilical vessel catheterization in the newborn have been reported by earlier investigators. This paper describes a case in which umbilical artery catheterization probably gave rise to an aortic aneurysm. The histological findings suggested that the hypoxic changes in the aortic wall as well as the mechanical effect of the catheter were involved in the origin of the aneurysm.

Aortic Aneurysm↗
PubMed1976

Relation between craniocerebral injury and subsequent myocardial fibrosis and heart failure. Report of 3 cases.

The findings at necropsy in three cases of severe craniocerebral injury associated with unconsciousness are reported with special reference to the histopathological findings in the myocardium. In the first case, death occurred 3 days after the trauma, in the second case 21 days after, and in the third case, 7 years after. Necropsy showed myocardial lesions of recent origin in the first case, stromal condensation in the myocardium in the second, and cardiac hypertrophy with coexisting patchy fibrosis of the myocardium in the third. The relation between craniocerebral injury and subsequent myocardial fibrosis is discussed.

Adolescent↗